Marker for homologous recombination deficiency, method and system for detection thereof

ABSTRACT

The present invention relates to a field of medical molecular biology, and in particular, a marker for homologous recombination deficiency (HRD), a method and a system for detection thereof. In the present invention, the genome-wide single nucleotide polymorphisms (SNPs) with a high heterozygous rate suitable for the Chinese population are provided by screening SNP sites on the gnomAD records and over 300 Chinese whole-genome sequencing (WGS) data, thereby establishing a HRD scoring method. The HRD markers provided by the present invention allow HRD to be effectively scored, having a calculation result in high consistent with the WGS result.

CROSS-REFERENCE TO RELATED APPLICATION

The presented application is a continuation of international PCT application serial No. PCT/CN2021/072605 filed on Jan. 19, 2021, which claims the priority of the Chinese Patent Application No. 202011208296.8, filed on Nov. 3, 2020 and entitled “MARKER FOR HOMOLOGOUS RECOMBINATION DEFICIENCY, METHOD AND SYSTEM FOR DETECTION THEREOF”. The entirety of each of the above mentioned patent applications is hereby incorporated by reference herein and made a part of this specification.

BACKGROUND Technical Field

The present invention relates to a field of medical molecular biology, and in particular, a marker for homologous recombination deficiency (HRD), a method and a system for detection thereof.

Description of Related Art

Homologous recombination repair (HRR) for DNA is an important way to repair DNA double-strand damage. HRR, an extremely precise pathway, is essential to maintain the stability and integrity of a genome. Approximately 50% of ovarian cancer patients have HRD.

At present, three PARP inhibitors (niraparib, olaparib, and rucaparib) have been approved for maintenance therapy of platinum-sensitive recurrent ovarian cancer. Wild-type patients with changes in the HRR pathway and molecular characteristics of BRCA mutant tumors (the so-called “BRCAness” phenotype) may also benefit from the therapy with the PARP inhibitors. The main clinical challenge is how to accurately identify such patients.

At present, there are various methods to identify BRCA wild-type tumor patients with HRD. The specific methods are as follows: (1) Record a large amount of genomic abnormalities, that is, the so-called “genomic scars”; (2) Mutation signal analysis; and (3) Two methods for identifying and detecting point mutations in HRR genes by using DNA sequencing panels:

One is the Myriad “myChoice HRD” assay method to calculate scores based on values of three Genomic Scars:

loss of heterozygosity (LOH),

telomeric allelic imbalance (TAI), and

large-scale state transition (LST).

HRD score≥42 or the BRCA1/2 mutant indicates HRD positive; and

HRD score<42 and the BRCA1/2 wild type indicate HRD negative.

The other is the “FoundationFocus CDx BRCA LOH” detection method including two main factors:

BRCA mutation status of tumors, and

genomic LOH level.

High LOH: proportion≥16%; and low LOH: proportion<16%.

The definition of HRD negative: BRCA wild type with low LOH.

However, in the foregoing detection methods, evaluation of the HRD score generally requires the data copy number of the whole genome, and requires information about a large amount of SNPs evenly distributed on the genome. In commercial high-density SNP microsequencing, such as Myriad, a large amount of heterozygous SNP sites have been specially designed on the genome to detect the status of specific regions of chromosomes, but it is low in sequencing depth so that the less abundant somatic mutations are not allowed to be detected. In large customized multi-gene panels, such as FoundationMedicine, its sequencing depth allows the somatic mutation to be detected, but it has a small number of heterozygous SNPs, allowing detection for LOH in specific regions, while insufficiency for assessment of the status of chromosomes of the whole genome.

SUMMARY

The present invention provides a marker for evaluating HRD of the Chinese population, having a determining result in high consistent with the scoring of the whole exome sequencing result.

A homologous recombination deficiency (HRD) marker is provided, including 8000-9000 SNP sites.

In an implementation, the information about the SNP sites is shown in Table 1.

A method for detecting homologous recombination deficiency (HRD) is provided, including the following steps:

sequencing a sample by the NGS method to obtain the foregoing information about the SNP sites;

obtaining information about loss of heterozygosity (LOH), telomeric allelic imbalance (TAI), or large-scale state transition (LST) at the SNP sites; and

calculating a scoring result of HRD of the sample according to a formula HRD=LOH+TAI+LST.

Use of a reagent for detecting the foregoing marker in the preparation of a reagent for evaluating homologous recombination deficiency (HRD) is provided.

In an implementation, the use further includes a step of scoring HRD, the scoring being calculated according to the following formula:

HRD=LOH+TAI+LST,

wherein,

LOH refers to the number of heterozygous loss regions that cannot span the entire chromosome and is at least 15 Mb;

TAI refers to the number of allelic imbalances in front of telomere ends of chromosomes; and

LST refers to the number of a chromosomal break region not greater than 3 Mb and a fragment of at least 10 Mb.

A device for evaluating homologous recombination deficiency (HRD) is provided, including:

a sequencer, configured to detect SNP sites shown in the table in a sample;

an LOH counting module, configured to determine and count the number of loss of heterozygosity (LOH) at the SNP sites;

a TAI counting module, configured to determine and count the number of telomeric allelic imbalances (TAIs) at the SNP sites;

an LST counting module, configured to determine and count the number of large-scale state transitions (LSTs) at the SNP sites;

an HRD counting module, configured to calculate an HRD score according to HRD=LOH+TAI+LST; and

a classification module, configured to evaluate whether the sample has HRD according to the HRD score.

Advantageous Effect

The HRD marker provided by the present invention allows HRD to be effectively scored, having a calculation result in high consistent with the whole-genome sequencing (WGS) result.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows comparison of the consistency of HRD results in selected regions.

FIG. 2 shows location distribution of SNP sites on the chromosome.

FIG. 3 shows comparison of the consistency of HRD scores.

FIG. 4 shows comparison of HRD scoring results of an actual sample.

FIG. 5 shows comparison of HRD scoring results of an actual sample.

FIG. 6 shows comparison of the consistency of scoring results between gnomAD and SNP sites in the present invention for the Chinese population.

DESCRIPTION OF THE EMBODIMENTS

LOH is often found in cancer, and the chromosomal region with heterozygous loss has varied B-allele frequency (BAF). As shown in the figure, BAF=50% in this region in healthy samples, and BAF=100% in tumor tissues due to LOH. Therefore, to fully detect HRD, a large amount of heterozygous SNP sites are designed in a panel.

In the present invention, the most common polymorphic sites based on Asians are obtained through screening, and in the present invention, the heterozygous SNP sites are uniformly provided on the entire human genome by NGS sequencing by using the foregoing panel composed of a plurality of SNP site regions spanning the entire genome. gnomAD v2.1 contains SNV and InDel records of 15708 WGS samples, including 780 East Asian samples. A gnomAD site heterozygosity rate is calculated based on an allele frequency of the East Asian population (EAS_AF) of gnomAD (gnomAD heterozygous rate=2*EAS_AF*(1−EAS_AF)). Sites with the highest heterozygous SNP in each region are selected with an interval of ˜300 bp. After the SNP sites are obtained by the foregoing method, the influence of the number of the SNP sites on the final classification performance is further investigated, and the HRD score is calculated by using heterozygous SNP capture regions.

In the present invention, the HRD score is calculated as follows:

The formula for calculation of HRD: HRD=LOH+TAI+LST, wherein:

1. LOH refers to the number of heterozygous loss regions that cannot span the entire chromosome and is at least 15 Mb.

2. TAI refers to the number of allelic imbalances in front of telomere ends of chromosomes.

3. LST refers to the number of a chromosomal break region not greater than 3 Mb and a fragment of at least 10 Mb.

The foregoing information can be obtained through the analysis of SNP site detection results by using existing bio-info software.

To determine proper number of heterozygous SNPs, 20 WGS samples were used for selective simulation, and the consistency of HRD results in selected regions was shown in FIG. 1.

First, calculation of the HRD values were performed on 4000, 4500, . . . , and 9000 SNP sites having a high heterozygous rate, which are randomly selected from the SNP sites having a gnomAD heterozygous rate≥9.5% with an interval of 200 kb to 400 kb according to a ratio of the length of each chromosome in the human reference genome, and the minimal SNP sites that enabled optimal classification performance were investigated, with results shown in FIG. 1.

It was found that when heterozygous SNP was between 8000 and 9000, Pearson R can reach 95%.

Next, the SNP sites with a high heterozygous rate suitable for the Chinese population were provided by screening SNP sites on these high heterozygous rate gnomAD records and 355 Chinese WGS Data. The actual SNP heterozygous rate (actual SNP heterozygous rate=number of people with heterozygosity/total number of people, WGS normal N=355) of each record was calculated. About 8300 SNP sites with a high heterozygous rate of the Chinese population were selected according to a heterozygous SNP gradient selection result (specific information about the SNP sites was shown in Table 1). FIG. 2 shows distribution of the selected SNP sites on the chromosome.

In the present invention, deficiency of the BRCA set is determined on a basis of double inactivation, that is, pathogenic mutations or deficiency occurs on two chains of chromosome corresponding to each gene, causing complete loss of function for the gene.

WGS and GoliathHRD sequencing were performed respectively on 20 samples from breast and ovarian cancer in the Chinese population (10 for BRCA Deficient, and 10 for BRCA Intact). The consistency of HRD scores was analyzed using the HRD score result of WGS as a gold standard, with results shown in FIG. 4. It can be seen from the figure that the result from determining by the HRD score is the most significant, and is better than other indicators.

In addition, GoliathHRD sequencing was performed on 208 samples from the Chinese population (141 for BRCA Intact, and 67 for BRCA Deficient), and the difference in the HRD score between the two groups was the most significant. The differentiation result was shown in FIG. 5. It can also be seen from the figure that the determining method of this patent also shows the best accuracy for classification, with p value significantly smaller than other determining methods having p value of 5.7e−15.

According to the same interval length, the same number of SNP sites with the highest gnomAD EAS heterozygous rate in each interval were selected to calculate the HRD value, and it was compared with the SNP result verified by WGS from the true Chinese population which is more consistent with the WGS result (see FIG. 6). It can be seen that the scores recorded by gnomeAD result in R of about 0.96 with p value of about 3.1e−12, while the SNP site combination in the present invention provides R value of 0.98 with p value of about 2e−13. Therefore, the site combination in the present invention is more suitable for scoring HRD for the Chinese population.

TABLE 1 SNP sites Chromo- Refer- Varia- Chromo- Refer- Varia- Chromo- Refer- Varia- some Location ence tion some Location ence tion some Location ence tion 1 105279 G C 1 251663 C G 1 649113 C T 1 649192 A T 1 743072 C A 1 924528 C A 1 1127507 G A 1 1127523 C T 1 1128429 G A 1 1128521 C T 1 1650410 T C 1 2488930 G A 1 2631804 G A 1 2693121 A T 1 3097439 C T 1 3097459 C T 1 3097464 A G 1 3097498 A T 1 3097509 C T 1 3097522 T C 1 3097532 T G 1 3097534 G A 1 3098219 C A 1 3098360 A G 1 3098386 G T 1 4196428 G A 1 4967739 G C 1 4967744 C A 1 5393906 G A 1 5876714 T A 1 5876956 A G 1 5876977 C A 1 5876988 A G 1 5877088 C G 1 5877112 C T 1 5877121 C A 1 5877138 G A 1 5877145 C A 1 5877169 C A 1 5877171 T C 1 5877327 A C 1 5877329 A G 1 5877337 G A 1 5877367 G A 1 5877384 C T 1 6481623 G A 1 9493601 C T 1 9494062 A G 1 9494142 T C 1 10357406 A G 1 11167760 C T 1 11167829 C T 1 11168529 A G 1 11174067 A T 1 11175176 T C 1 11181630 G A 1 11189191 G A 1 11193401 A C 1 11193406 C T 1 11193408 C T 1 11209899 T C 1 11227224 C T 1 11269796 T C 1 11292753 A G 1 11293200 C T 1 11293216 A G 1 11293792 A C 1 11303610 T C 1 11307412 G C 1 11315853 G A 1 11318763 C G 1 11318983 T C 1 12188028 C A 1 12854713 G T 1 12854716 A G 1 12886052 C T 1 12886098 T C 1 12886436 C A 1 12920067 C G 1 12920132 A G 1 12920191 T C 1 12920200 G A 1 12920622 C T 1 12920708 C A 1 12940618 A G 1 12940822 A T 1 12941059 C A 1 12941086 C A 1 13143375 G T 1 13143405 A G 1 13143441 C T 1 13143453 C T 1 13367310 C G 1 13367310 C T 1 14228227 C G 1 14228236 A G 1 14228340 G C 1 14228356 T C 1 15829457 C G 1 16451413 C T 1 16460541 T C 1 17345113 G C 1 17348847 G C 1 17350243 T C 1 17353988 T G 1 17370970 C T 1 17687161 G C 1 18476868 T C 1 18476876 A G 1 18477394 A C 1 18477450 G A 1 20058523 A G 1 20915418 C G 1 20916080 C G 1 20931774 A G 1 20944721 G A 1 22234424 G C 1 22301165 C T 1 22301180 G A 1 22301199 C T 1 22301755 A G 1 22301769 G A 1 22301770 C T 1 22301824 T C 1 22326109 T C 1 22326455 T C 1 22326488 T C 1 22326548 A G 1 22326587 G A 1 23909324 T A 1 24192453 T C 1 26228409 A G 1 28439964 C T 1 28563391 C T 1 29232578 C G 1 31581492 C T 1 31857847 G A 1 31857869 G A 1 31857916 C T 1 33819830 A C 1 34989237 G A 1 37049763 C T 1 37568312 C G 1 38010651 G A 1 38010751 C T 1 39944488 T G 1 40367607 G C 1 40367625 G T 1 40799427 G A 1 41940980 C T 1 42042317 C T 1 42042915 C T 1 43803222 G A 1 44606254 C T 1 44606565 A G 1 45880669 C T 1 45880751 C T 1 46727304 C T 1 46737961 C T 1 47009757 G A 1 47009799 A G 1 47009829 G T 1 47541531 C A 1 48119989 C T 1 48120087 T C 1 50591705 C G 1 50591743 C T 1 53116251 A G 1 55390669 T C 1 55834642 G A 1 55835253 G A 1 57548321 C G 1 59621601 C T 1 59621636 A T 1 59622219 G A 1 59622225 T G 1 61465647 C G 1 62148611 A G 1 63521709 T C 1 63521755 T C 1 64117913 A G 1 65301317 G A 1 65301490 G A 1 65301611 T G 1 65303338 A G 1 65303390 G A 1 65312583 C T 1 65312949 A G 1 65335343 C G 1 65338745 C T 1 65338775 C T 1 67822377 A G 1 68628372 G A 1 71012395 C A 1 72571656 C A 1 73095148 G T 1 77259478 G A 1 77754620 A G 1 80363334 G C 1 82467045 T C 1 82843604 G T 1 83054685 T C 1 83054799 C T 1 83055055 T C 1 83055137 G T 1 83055238 G T 1 84295861 A G 1 85229792 G C 1 86050077 C G 1 86873847 C T 1 87106420 T C 1 89849268 T C 1 90271586 T C 1 90673701 C T 1 90673754 G A 1 91658629 G A 1 91659249 G A 1 91659289 A T 1 92082962 C T 1 96479066 T A 1 96993374 C A 1 96993449 T C 1 97838854 C T 1 97839413 C G 1 97981706 C T 1 99692027 A G 1 100270805 G C 1 102251801 A G 1 102427608 C T 1 103047194 C T 1 105484566 G A 1 106740553 T G 1 107182505 A T 1 110231592 T C 1 110231777 G A 1 110232087 C T 1 110233138 G C 1 110233147 C T 1 110235607 A G 1 110255174 T G 1 110256473 C G 1 111857685 G C 1 111858291 T C 1 112033285 G C 1 113234456 G A 1 117786992 G A 1 117787502 C A 1 118136824 T C 1 118136861 G A 1 118136912 G A 1 119762037 T C 1 119992928 T C 1 119992995 C A 1 119992999 A G 1 120462468 C T 1 120463230 C T 1 120483921 G C 1 120495934 G C 1 120498086 G C 1 120508803 T C 1 120509783 A G 1 120547695 A G 1 144838618 A C 1 145931852 A C 1 146465784 C G 1 146555193 T C 1 147534441 T A 1 148004440 C A 1 148004899 T A 1 148756363 A G 1 148756397 C T 1 148756432 C A 1 148756499 A G 1 148756515 A C 1 148854651 A C 1 148855855 C T 1 149067299 G A 1 149089962 A C 1 149521316 A G 1 149521391 A T 1 149606839 C G 1 149607021 A G 1 149607027 G A 1 152277345 C T 1 152277396 T C 1 152278689 C A 1 152279406 T G 1 152280032 T C 1 152280170 C G 1 152281007 A G 1 152281008 A G 1 152281039 G A 1 152760075 A G 1 152760093 T C 1 152760096 A T 1 152760628 T C 1 152760642 C T 1 152760644 C T 1 152760647 C A 1 152760651 C T 1 152770521 G A 1 152770533 G A 1 152770589 A G 1 152770828 A G 1 153277768 C T 1 154351073 T C 1 155583937 A G 1 156785356 T C 1 158165578 G A 1 158165601 T C 1 158165661 T C 1 158165722 G A 1 158165742 A T 1 158165938 A C 1 158165984 C T 1 158220870 T C 1 158736215 G A 1 159086711 A G 1 160093648 G A 1 160236470 T A 1 161293193 C T 1 161293215 A G 1 161293646 T C 1 161293708 G A 1 161297993 T C 1 161310719 C T 1 161326201 C T 1 161326274 A G 1 161326293 T C 1 161558725 C T 1 161559082 C T 1 162470503 G A 1 163033342 A C 1 166245169 A G 1 166245170 G C 1 166541921 T C 1 167638203 T C 1 167638251 T G 1 168365929 C G 1 168513243 G A 1 168513692 C T 1 168545758 C T 1 177940341 C T 1 177940348 C T 1 178922201 A T 1 179335158 C T 1 179335162 G C 1 180162293 G C 1 180162364 C T 1 181394677 G C 1 181828178 T G 1 186256808 A G 1 188674740 C A 1 189555573 G C 1 191151643 G T 1 191152225 C T 1 191719275 A T 1 192017093 C G 1 194952546 G C 1 195371632 G A 1 196788601 C T 1 196912415 C T 1 198340898 T C 1 199449355 C T 1 199548706 C G 1 201178470 G A 1 201489285 G C 1 201489286 C G 1 201489302 C T 1 201489565 C T 1 201978049 C T 1 201978068 G A 1 202096562 T C 1 203274536 C A 1 203842900 C T 1 203843484 T C 1 204315839 T G 1 204494436 C T 1 204495253 G A 1 204500257 G A 1 204511704 T C 1 204513402 G A 1 205816893 T C 1 205816923 G A 1 206646274 G T 1 206646311 C T 1 206647387 T G 1 206647450 A G 1 206669136 C A 1 207807908 C T 1 207807921 G C 1 207807928 G A 1 207808385 C G 1 208164511 C T 1 208780934 A C 1 210371949 A G 1 210372455 T C 1 210827321 T C 1 210827322 G A 1 210827379 C T 1 211126407 G A 1 211855564 G A 1 211855593 T A 1 212224761 A G 1 212224946 G T 1 212240533 A G 1 212245792 A G 1 214386346 T G 1 214386351 C T 1 214386365 A T 1 214571527 C G 1 215128241 C T 1 216840332 G C 1 216840371 C T 1 216840798 C T 1 218238495 T C 1 218572004 G A 1 219969405 T C 1 222477115 C A 1 222642478 C A 1 222642700 G A 1 222677791 C G 1 223089124 G A 1 223718462 G A 1 223718518 C A 1 224164610 G A 1 224220492 A G 1 224220734 G A 1 224644312 C T 1 226549498 G A 1 226553934 A C 1 226557878 T C 1 226580187 T C 1 227680600 G A 1 227680783 T C 1 227680868 T C 1 227681213 T C 1 227681563 A G 1 227681567 T C 1 227695408 T G 1 227695429 C G 1 227695486 G A 1 227695818 C T 1 227695830 C T 1 227695868 G A 1 227696002 A G 1 227696033 T C 1 227696110 G A 1 228156074 C T 1 228163615 A C 1 228163691 A G 1 228164114 G C 1 228164190 G A 1 228164584 A G 1 228165010 A G 1 228457036 T A 1 228457543 G A 1 228716894 C T 1 229824770 T C 1 231146762 G A 1 231146770 G C 1 232491583 T G 1 233280999 T A 1 234126736 G A 1 234127282 C G 1 234127319 C T 1 234128435 A G 1 234128441 A T 1 234128967 C T 1 234948160 T C 1 235049923 A C 1 235702712 C T 1 236919092 T G 1 236919146 G A 1 237410497 C G 1 237410504 G C 1 237445099 T C 1 238113949 T A 1 239800851 C T 1 240451555 T C 1 240451568 C T 1 241665510 A G 1 241671638 C T 1 242453104 C T 1 242819974 T G 1 243204262 G T 1 243245426 C T 1 243662773 T C 1 243801190 T C 1 243828306 T A 1 244891367 A G 1 244891415 G A 1 245856763 G A 1 246362962 T C 1 246363094 G C 1 246641904 T C 1 246642046 A G 1 246642078 T C 1 246642155 A G 1 247337911 A C 1 247338427 A G 1 247591141 G A 1 248084854 A G 1 248084909 T G 1 248085341 T A 1 248436611 G A 1 248436616 A G 1 248907914 G T 1 248907917 C T 1 248907919 C T 2 197601 A G 2 197712 T C 2 1366783 G A 2 1366859 G A 2 1833356 T C 2 1833781 G A 2 2413270 T G 2 2413783 C T 2 2940325 G A 2 2940329 A G 2 3332735 A G 2 3333243 T G 2 3877140 C T 2 3877747 G A 2 4561867 T C 2 5389739 A G 2 5768841 C G 2 6426700 T C 2 6426703 C T 2 6943743 C A 2 7068710 C G 2 7999597 G A 2 9446167 C A 2 9446205 G A 2 10381717 C T 2 10676227 C G 2 10676309 C T 2 10676315 A G 2 10676317 T G 2 10676320 G A 2 10676368 T C 2 10676498 T C 2 10676610 G A 2 11093401 T C 2 11093430 T C 2 11242610 C T 2 11994573 A C 2 11994575 G A 2 11994645 A G 2 11994813 A G 2 11994822 C G 2 11994829 T A 2 11994840 T A 2 11994849 T C 2 11994863 A C 2 11994865 G A 2 11994907 T C 2 13981557 C T 2 14082251 G T 2 15832606 G A 2 16086469 C T 2 19524172 T G 2 21634473 T C 2 24167417 T G 2 24439048 A G 2 25458379 G A 2 25472784 C T 2 25505793 T C 2 25522795 G A 2 26367863 T C 2 26835397 C A 2 26835419 G A 2 27615389 C T 2 28350922 G A 2 29416946 T C 2 29432982 C T 2 29436633 G T 2 29437182 T C 2 29451511 C G 2 29940820 C T 2 30142547 G C 2 31552688 G C 2 31553158 C G 2 33896721 G A 2 35130065 T G 2 36768719 C G 2 37050374 A G 2 37996061 C T 2 38002857 T G 2 40783500 C G 2 40783501 T C 2 41273446 A C 2 41273450 T C 2 43779665 T C 2 43783241 C A 2 43783273 G A 2 43787758 G C 2 43798616 C G 2 43802347 T A 2 43802380 C G 2 43803897 A C 2 44274227 G C 2 44274729 A G 2 44292977 C T 2 44985166 C G 2 45576533 C A 2 45577081 A G 2 46064330 A G 2 46525391 G C 2 46588488 G T 2 46597296 T C 2 46603260 C T 2 46603438 A G 2 46604857 T C 2 46605659 A G 2 46611471 G A 2 47597029 C A 2 47602241 T C 2 47606683 T C 2 47612156 A G 2 47639871 T G 2 47643191 C G 2 47672475 T A 2 47698384 G A 2 47703241 A G 2 47703984 T G 2 47709704 T C 2 48022900 A G 2 48914615 C G 2 48941428 C T 2 48952574 C T 2 48956475 C T 2 48956512 A G 2 48958595 A G 2 48958626 A G 2 48958647 C T 2 48982358 G A 2 49070593 G C 2 49071094 G C 2 49660621 A T 2 50231869 G A 2 50232465 C T 2 50763570 A G 2 51450722 A G 2 52153976 T C 2 53792407 T C 2 55066617 G C 2 56338148 G T 2 58453585 T C 2 58453620 C G 2 59260307 G A 2 61183901 A G 2 62373915 T C 2 64720254 G A 2 64892858 G T 2 65863984 T G 2 65864061 C G 2 66063089 A G 2 66955742 C T 2 68999640 G A 2 71256898 G T 2 71256905 C A 2 71256965 G A 2 71283017 G T 2 71283128 G A 2 71283247 G A 2 71283425 T G 2 73295583 G A 2 73869120 G A 2 73869558 T C 2 75089569 A G 2 75090155 G A 2 76124531 C T 2 76124535 C T 2 76890353 T A 2 77637227 A T 2 79445642 A T 2 80101025 G A 2 80101040 A G 2 81423752 T C 2 83419234 G C 2 84073752 A T 2 84074312 A G 2 85141323 A G 2 85685734 A G 2 87405001 T C 2 87405397 G A 2 87444116 A G 2 87444177 A G 2 87444438 C T 2 87615504 A G 2 88433305 T C 2 88739133 T A 2 88739134 C G 2 88739141 C A 2 88739644 C G 2 89080379 C T 2 89080394 C A 2 89080854 C G 2 90447633 T C 2 90448948 A G 2 90448956 C T 2 90449010 G T 2 91671081 C T 2 91671100 T C 2 91671122 C G 2 91715572 T C 2 92151397 G A 2 95849653 T C 2 96596710 G C 2 96809331 T C 2 96920993 C T 2 97366088 T C 2 97366599 A G 2 98223750 A G 2 99537295 A C 2 101350715 G A 2 102254291 T G 2 102254307 G A 2 102254364 C G 2 102616745 G T 2 102617204 T C 2 104432433 T C 2 104432494 A C 2 104599371 T G 2 105671951 C T 2 105672240 T G 2 106543154 A T 2 107019359 T C 2 107019383 G T 2 107019457 T C 2 107019874 T C 2 107424428 C T 2 108481932 C G 2 109928180 C T 2 109928207 G T 2 110800798 C A 2 110800846 G A 2 112289514 C A 2 112289579 T C 2 112506112 C T 2 112506288 T C 2 112544651 G A 2 113691060 T C 2 113691288 T C 2 113869803 C T 2 113869843 C A 2 114256098 G A 2 114256343 A G 2 114259673 C A 2 114288352 G T 2 119480974 C T 2 120130317 C T 2 120130337 C T 2 120130347 G T 2 121321830 C T 2 122995587 G T 2 122996267 C T 2 123153811 A G 2 123154175 A G 2 123921841 C A 2 124206212 G T 2 124206727 G C 2 124206743 G A 2 125189819 A T 2 127420931 A G 2 127811810 C T 2 127812457 G A 2 127812468 A G 2 128018522 T C 2 129473008 C T 2 130126515 A G 2 130801047 T C 2 130805820 T C 2 131233331 C T 2 131945811 C A 2 131947586 C T 2 131955247 G C 2 132045098 C G 2 132046355 C T 2 132107348 A C 2 132181110 C T 2 132533478 T C 2 132534075 G T 2 132579856 G A 2 132579930 A G 2 132580131 A C 2 132796086 G A 2 132796335 A G 2 132796339 A G 2 132797478 G A 2 132809855 A G 2 132809875 G A 2 132809905 G T 2 132872466 C A 2 132872691 A G 2 132872847 G T 2 132905500 C T 2 132905513 C A 2 132905976 G A 2 133644992 T A 2 133645369 G A 2 133645476 G A 2 134945535 A G 2 134946060 T C 2 137181641 C A 2 137181641 C G 2 137181661 C T 2 137900678 A C 2 140000027 A G 2 140991087 A C 2 140992063 G C 2 141028164 C T 2 141055080 T G 2 141072930 C T 2 141114235 C G 2 141128001 C G 2 141129072 T C 2 141136007 T C 2 141202412 C T 2 141202499 T A 2 141245486 G A 2 141271959 T G 2 141272545 G A 2 141283130 T C 2 141284090 C G 2 141293912 G T 2 141299730 T C 2 141299775 C T 2 141355954 C T 2 141457603 G C 2 141460317 T A 2 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178740393 C T 2 178740398 C G 2 178969434 G C 2 179296821 G A 2 179729081 C T 2 180308028 C T 2 180734989 A C 2 181490053 C T 2 181490633 G C 2 182433865 G A 2 182433873 G T 2 182434468 G A 2 182434507 A G 2 183726713 C T 2 184128825 A G 2 184912216 T C 2 184912648 T C 2 187169224 G A 2 187866471 C T 2 187867057 G A 2 190176234 G T 2 190176235 C A 2 190708982 C A 2 190741733 G A 2 190742374 A G 2 192422875 G T 2 193726153 C T 2 193726212 T C 2 193726268 A G 2 194468850 T C 2 195079687 G C 2 196335442 T G 2 197037730 G A 2 198273591 C T 2 198274929 G A 2 198285554 C G 2 198905073 T A 2 201487990 C T 2 212252955 C T 2 212292929 G C 2 212530466 C T 2 212543510 T C 2 212544193 T C 2 212566477 G A 2 212569828 C T 2 213296501 T G 2 214019110 T C 2 215595440 T A 2 215595445 C A 2 215610777 T C 2 215617500 T C 2 215631987 A G 2 215632629 G T 2 215645030 T C 2 215645046 C T 2 215672347 C T 2 215672827 C T 2 215672833 A G 2 216203296 A G 2 216860550 A T 2 217021055 A G 2 217453875 T C 2 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C 3 4665123 A G 3 5131185 C G 3 7888983 T C 3 8730717 G A 3 8730781 A C 3 9877716 G A 3 9877783 G A 3 10030236 T C 3 10030521 T C 3 10034925 G C 3 10035601 C T 3 10075983 T C 3 10075991 A G 3 10078247 A G 3 10078289 G C 3 10080722 T C 3 10083169 C T 3 10085816 G T 3 10094418 T C 3 10102377 T A 3 10104186 A T 3 10106924 G A 3 10108745 G C 3 10119603 C A 3 10122575 T C 3 10131831 C T 3 10133710 G A 3 10134766 C T 3 10140115 G A 3 10183274 C T 3 10183337 G A 3 10191219 C G 3 10191943 G A 3 11041606 G A 3 11042207 T C 3 11767152 A G 3 11902162 G A 3 11911822 C A 3 11912512 A C 3 11912534 T C 3 11912557 G A 3 11912622 G A 3 11912635 C T 3 11913124 A G 3 11913188 A G 3 11915481 C T 3 11924678 C G 3 11925226 G A 3 11925254 T C 3 11926243 C G 3 11926269 G A 3 11926423 A G 3 11926467 A G 3 11926508 A G 3 11926604 A G 3 11926734 T G 3 11928126 T G 3 11928127 A T 3 11928469 G T 3 11932455 T G 3 11933223 T C 3 12299313 A G 3 12632652 G C 3 12633552 T C 3 12829030 A G 3 12829036 C T 3 12829040 G T 3 12829095 A C 3 12829156 A G 3 13152051 T C 3 13152457 C T 3 14189147 A G 3 14212258 C A 3 15516820 C T 3 16408371 C T 3 16408389 G T 3 16408401 G C 3 16408402 G A 3 16408413 G A 3 16408424 C T 3 16408445 G A 3 16408451 C T 3 16408457 C T 3 16408487 C G 3 16408494 T C 3 16408499 C T 3 16408500 A G 3 16408503 G T 3 16408519 G A 3 16408533 C T 3 16408534 A G 3 16408536 G A 3 16408793 T G 3 16408949 T C 3 16408990 G T 3 16740865 A G 3 18412689 G T 3 19405951 T A 3 21805928 G A 3 22485461 T C 3 22998179 C T 3 22998724 G T 3 22998753 C T 3 22998818 T C 3 22998824 A G 3 23128544 T C 3 24355183 A T 3 24355275 G A 3 25619630 G C 3 25620233 T A 3 26445467 T C 3 27432779 C T 3 27432871 G A 3 27756251 T C 3 30686627 T C 3 30686647 T C 3 30715977 C T 3 30729636 G A 3 32071969 G A 3 32072004 T C 3 32195427 T C 3 32232782 G T 3 32301422 C A 3 32301426 C T 3 33086893 T C 3 33841065 A G 3 36148273 C T 3 36148306 T G 3 36148330 C T 3 36148763 G C 3 37067050 A G 3 37627598 T C 3 37790112 C T 3 38737643 T C 3 40439614 G A 3 40440116 G A 3 40537215 C A 3 41269152 A T 3 45251978 G A 3 46511969 G A 3 47083782 C G 3 47103376 C T 3 47108330 C T 3 48486773 G C 3 48487338 G A 3 48487353 A C 3 51102839 G A 3 51755441 G A 3 52597664 G A 3 52621839 C T 3 52659124 T C 3 52678494 G A 3 53884074 G C 3 53999979 A G 3 55738985 T G 3 56235603 C A 3 56737197 C T 3 58036651 T C 3 58594418 C A 3 59701045 C T 3 60439446 T A 3 60545661 T A 3 61557787 G A 3 63442932 A T 3 63443008 A C 3 64184676 G A 3 65289882 C T 3 65734943 T C 3 66077019 T C 3 66077076 A T 3 66077167 G A 3 66077485 G A 3 66746914 T C 3 67145056 T C 3 69392244 G T 3 69392263 T C 3 69392331 C A 3 69392754 G A 3 69392762 G A 3 69392793 T C 3 70013349 A G 3 71847123 A G 3 72978434 T C 3 73433369 G A 3 74513397 A G 3 74514007 T C 3 75365484 T C 3 75366035 C T 3 75397290 A G 3 75475805 A G 3 75572090 T C 3 75572133 C G 3 75572165 G C 3 75572199 C T 3 75572202 T C 3 75572238 G A 3 75572329 G C 3 75572368 A C 3 75572374 G C 3 75875639 A C 3 75875740 G A 3 75875973 G A 3 75876015 T G 3 75876023 A G 3 75876115 G A 3 76779549 C G 3 76779577 T G 3 76780491 A G 3 77338588 A C 3 77338630 G T 3 77338634 T C 3 77338635 A C 3 77338636 A C 3 77338640 T C 3 77338835 G C 3 77338920 T C 3 77339156 G C 3 77339675 T G 3 77340008 T C 3 77345372 T G 3 77345549 G A 3 77345598 G A 3 77459994 T C 3 80457094 G A 3 81833577 T C 3 81833966 G A 3 81834060 G A 3 81834065 T A 3 83497272 A G 3 84924659 T C 3 85870199 A T 3 86702627 G T 3 87386674 T C 3 87695509 C T 3 89176645 A G 3 89444743 G T 3 89448936 T A 3 89498096 C A 3 89521965 T G 3 89528313 T G 3 93903910 G A 3 95886072 A G 3 97940846 C T 3 97957539 C T 3 97957580 G C 3 97957609 C T 3 97957611 G A 3 97983257 C G 3 97983265 C A 3 97983711 T C 3 98840224 C T 3 101620615 G A 3 101620682 A G 3 102650845 G C 3 103705800 A T 3 104106527 G A 3 104106528 G A 3 104106562 C T 3 104639822 T C 3 105377515 C T 3 105400846 A G 3 105420602 C T 3 105422536 T C 3 105439311 T A 3 105452593 A G 3 105459717 A G 3 105571964 C T 3 105586714 T C 3 107805553 C G 3 108034167 A C 3 109128553 G T 3 109128692 C T 3 109775371 G A 3 109775869 G A 3 110496808 T C 3 112243112 A C 3 112352718 A G 3 112933625 A G 3 112933635 T C 3 117156240 G A 3 117156255 C T 3 117156294 C A 3 117156738 T C 3 119272235 T C 3 119419376 G A 3 120402581 G T 3 122380722 C A 3 123957278 C T 3 123957294 C G 3 124410346 A G 3 124840312 T A 3 125431505 A C 3 125431673 A T 3 125453782 G T 3 125453797 C T 3 125453908 G T 3 125453977 A T 3 125454162 C G 3 125454180 A C 3 125482012 T G 3 125482430 C T 3 125484006 G C 3 125484009 C T 3 125494802 T C 3 125494864 T C 3 125495356 A G 3 125495487 T C 3 125495558 A G 3 125639885 C A 3 125639911 C T 3 125643329 G A 3 125643332 A G 3 125643719 A G 3 125643772 G A 3 126254692 G A 3 128201013 A C 3 129309455 G A 3 129722895 G A 3 129724802 C T 3 129804885 C G 3 129805060 C A 3 129805077 C T 3 129805236 A G 3 129821816 C G 3 129821817 C T 3 129822217 C T 3 129822218 A G 3 129822230 T C 3 129825954 T G 3 129825955 A G 3 129826002 G T 3 129826513 T C 3 129828037 C A 3 129828078 T G 3 129919713 C T 3 129920258 C T 3 130745968 C T 3 130745981 A G 3 131138571 C T 3 131138589 A G 3 131138658 C T 3 133124049 C T 3 141485046 T C 3 142232743 A T 3 142233990 T C 3 142234534 G A 3 142234589 C A 3 142271797 A C 3 142273032 T C 3 142274534 C T 3 142279796 T C 3 142659361 A G 3 143426876 C T 3 143427340 C G 3 144276648 A G 3 145139463 T C 3 145139946 A T 3 147955974 G T 3 148649659 C A 3 148649678 C T 3 148650252 G A 3 149181661 C T 3 149271087 T C 3 149657658 C T 3 151053633 T C 3 152685955 T C 3 152686473 A G 3 152686523 G A 3 152686545 C T 3 153099380 T C 3 155829938 A C 3 155830631 C T 3 156174496 G A 3 156880573 T C 3 156880587 A G 3 156880688 A G 3 157559512 A G 3 158780937 A G 3 159490097 C T 3 162693420 C T 3 162693961 T A 3 164940782 A G 3 164941295 G A 3 165796202 A G 3 165796228 A T 3 166033539 G A 3 166580001 C T 3 166749739 T C 3 167800290 T C 3 169200968 C A 3 169201226 G A 3 169427817 A G 3 169977589 T C 3 169978059 A G 3 169981058 G A 3 169985539 C A 3 169986068 T G 3 169988658 G A 3 169998506 A G 3 170009952 G A 3 170021160 G A 3 171071949 T G 3 171684965 G A 3 172126162 C T 3 173114305 A G 3 173874385 G A 3 173874469 G T 3 174056020 C G 3 174562570 G T 3 174562655 G T 3 174562942 A T 3 174563022 G A 3 175937783 T C 3 176405586 C T 3 177744450 G A 3 178927111 C A 3 178927149 T C 3 178935799 T C 3 178938554 A T 3 178948385 A T 3 180424060 C T 3 181994593 C T 3 181994594 G A 3 182332176 T A 3 182735211 T G 3 183204239 A G 3 184220524 G T 3 184220528 T C 3 184220531 G A 3 184220534 T C 3 184220549 A G 3 184220588 C T 3 184220608 G C 3 184220819 G A 3 184220848 G C 3 184220849 G A 3 184220864 C T 3 184220865 A G 3 184220878 G C 3 184220879 G A 3 184220880 T C 3 184220890 T C 3 184220894 T C 3 184220902 A C 3 184220907 A T 3 184220910 T C 3 184220915 A G 3 184220920 T C 3 184220924 C T 3 184220940 C T 3 184220945 G A 3 184220948 T A 3 184220950 T C 3 184928239 T C 3 186508574 G C 3 188293043 T C 3 189382904 T C 3 189383430 C T 3 190093573 G C 3 190093689 G T 3 190093915 T C 3 190094003 T C 3 190094024 G A 3 191093053 T C 3 191093080 A G 3 191741924 C T 3 191742322 G A 3 194426037 C A 3 194712317 C A 3 194723092 G T 3 195384760 G C 3 195384844 T G 3 195399268 A C 3 195436937 A C 3 195437073 A G 3 195437584 G C 3 195437844 T G 3 195437869 C T 3 195437970 T C 3 195437979 T G 3 195437988 T C 3 195437989 C G 3 195437990 A C 3 195437994 A G 3 195438024 T G 3 195438126 T G 3 195438174 A G 3 195438443 T C 3 195438480 A C 3 195692049 G T 3 195692516 C T 3 195692570 G A 3 195700978 A C 3 195701115 A G 3 195709312 G C 3 195709355 C G 3 195717337 C G 3 195872302 C T 3 195872790 T G 3 196379737 C G 3 196759586 C A 3 196759600 A G 3 196759604 T G 3 196759761 A C 3 196759779 A G 3 196760400 C T 3 196760409 G A 3 197110726 C T 3 197112110 C A 3 197114790 A G 3 197114791 G C 3 197114962 T C 3 197115282 A C 3 197115557 T G 3 197115558 C T 3 197115602 A G 3 197116179 G A 3 197116267 A G 3 197116296 T C 3 197116307 G C 3 197116710 G T 3 197118688 T C 3 197354725 C T 3 197354733 T G 3 197354857 C A 3 197354909 C A 3 197825954 G A 3 197825956 G A 3 197826004 G A 3 197826013 C A 3 197826025 G A 3 197826185 G A 3 197832131 C T 3 197832181 C T 3 197832551 A G 3 197832937 G C 3 197832951 G A 3 197851897 G A 4 329501 G T 4 1266462 G A 4 1267160 T C 4 1267203 G T 4 1732410 C T 4 1736737 T C 4 1738732 C T 4 1740539 T C 4 2432104 G A 4 2699972 T C 4 3536882 A G 4 3547346 T C 4 3903137 G A 4 3903256 C T 4 3903553 G A 4 3903604 A C 4 3952705 A T 4 3952730 T C 4 3953310 A G 4 3953330 A G 4 3953359 A G 4 3953364 C T 4 3954873 A T 4 3954878 T C 4 3974295 G T 4 3974296 A T 4 3974455 C A 4 3974546 A G 4 3974559 T C 4 3974583 G C 4 4060689 G A 4 4061299 T C 4 4099959 G A 4 4112309 A G 4 4112604 A G 4 5189645 G A 4 5189717 A T 4 5652298 G C 4 6200768 C T 4 6881739 G C 4 6881785 G C 4 8999303 T A 4 8999512 C T 4 9001121 G A 4 9001176 G C 4 9001703 T C 4 9012383 A T 4 9052653 G C 4 9137789 G C 4 9137790 A G 4 9137990 G A 4 9158848 G A 4 9159079 T G 4 9159219 C T 4 9159256 C G 4 9163190 A T 4 9271895 T G 4 9531098 A G 4 9532659 G T 4 9584058 G A 4 9673458 T C 4 9673980 C T 4 9696823 G A 4 9700910 A T 4 9757407 G A 4 9757485 G A 4 10180622 T C 4 10180643 T C 4 10726609 G A 4 10726610 C T 4 10726707 C T 4 12056196 T C 4 13031210 T G 4 14232397 C T 4 14837656 C T 4 15117509 G A 4 15733093 C A 4 15733108 G T 4 15733159 A G 4 17348027 A G 4 17503839 G A 4 18056140 C T 4 18798633 C A 4 19250760 C T 4 21551721 T C 4 21552230 A G 4 23715644 C T 4 24142003 A C 4 25721273 C T 4 27128768 C T 4 27683108 T A 4 28247387 G A 4 28247910 G A 4 28551237 G A 4 29333030 C T 4 29333037 C T 4 29707479 G A 4 30290545 A G 4 30290549 T A 4 31017144 C G 4 31017221 C T 4 31761297 G A 4 32592869 C G 4 32592949 C T 4 33642926 T C 4 34985401 T G 4 34985806 G A 4 35510086 A C 4 35510132 C T 4 35510659 A G 4 35510681 A G 4 36329799 A C 4 36330306 T A 4 37002365 T C 4 37002380 A G 4 38512602 T C 4 39482627 T C 4 39482684 A C 4 39483115 A G 4 39483162 G A 4 40022837 A G 4 40022870 C T 4 40023258 T C 4 40835384 T A 4 40835854 C A 4 41748511 T G 4 42608665 T C 4 46241769 G A 4 46763980 A C 4 47493210 C G 4 49292437 T G 4 49298634 A C 4 49304353 T G 4 49304428 A C 4 49304465 T C 4 49304469 T A 4 49314901 C T 4 49321018 A G 4 49321104 G T 4 49617655 C T 4 49628621 C T 4 49628869 T A 4 49628914 A C 4 49629091 T C 4 49629144 G A 4 49629145 T C 4 52978719 C A 4 52978741 T C 4 52979321 T C 4 53454588 T G 4 54430834 T C 4 55136027 G C 4 55136245 A G 4 55137183 T C 4 55143321 C T 4 55146926 T A 4 55146927 T A 4 55161047 C G 4 55523938 G A 4 55524533 C G 4 55573693 G A 4 55602451 C T 4 55962165 A T 4 55962166 C T 4 55967806 A G 4 55971400 G A 4 55974290 C G 4 55985142 A G 4 55985149 A G 4 55985209 C G 4 55991731 T C 4 57917346 G T 4 58969178 C G 4 58969622 A C 4 59117179 C A 4 59685846 A G 4 63895205 T A 4 64379405 A G 4 64931039 T C 4 66270412 C T 4 66355888 T C 4 66355901 G T 4 67970457 T C 4 69901970 C T 4 70354884 G A 4 72347419 G T 4 73292973 C T 4 74322255 T C 4 74738851 G A 4 75394764 A G 4 75395312 G A 4 75395322 C A 4 78990229 C A 4 78990900 C A 4 79482186 G A 4 79602718 G A 4 80386263 T G 4 80801388 T A 4 84013033 C T 4 86340131 C G 4 86340164 G A 4 87264746 T A 4 87264750 G A 4 87692129 T G 4 87695876 T A 4 87718279 G A 4 87732483 C T 4 87791437 C T 4 89777379 C G 4 90228238 C T 4 93487149 A T 4 93487465 C A 4 95088301 T C 4 95606136 T C 4 99443068 A G 4 99443113 A G 4 99443127 T C 4 99443569 T C 4 99443585 G A 4 99443611 A T 4 100238998 T C 4 101572039 G A 4 102854264 C T 4 104452689 T A 4 106164284 T G 4 106193588 A G 4 106914301 C T 4 106914306 A T 4 106914338 C T 4 106914855 G A 4 108124872 G A 4 108125157 G A 4 108125170 C A 4 108565609 G A 4 111944989 A G 4 113180779 C T 4 113181343 T C 4 113486769 T C 4 115241715 C G 4 115987887 A T 4 116002140 T C 4 117957242 T G 4 118496905 A G 4 118496919 T C 4 118497508 C G 4 118503372 C T 4 119252323 C T 4 119252368 G A 4 119526740 C G 4 119527206 C T 4 119944319 A G 4 119944900 A G 4 119944903 C A 4 120133549 T G 4 120324707 T C 4 120325264 C T 4 120325273 T C 4 120355709 T C 4 120751902 T A 4 121089766 G C 4 121738049 T C 4 122290719 G A 4 122290979 G C 4 122291131 T G 4 122431338 T C 4 122683623 C T 4 124946414 C T 4 124946423 A G 4 125173747 C T 4 125725127 A G 4 127856273 T G 4 128518960 C T 4 132832700 T G 4 132832731 A G 4 133045796 A G 4 133824971 A G 4 133825066 G A 4 133825500 C T 4 133825533 A G 4 133885960 T G 4 134784133 G A 4 137489544 C A 4 137985807 C T 4 138698629 T A 4 139796813 G A 4 140619075 T C 4 143003526 A G 4 143034019 A T 4 143034029 G A 4 143044829 A G 4 143045482 G A 4 143066775 A G 4 143095131 C T 4 143095139 C T 4 143095201 C T 4 143114003 T C 4 143114011 A G 4 143114040 A C 4 143114482 T C 4 143114548 A G 4 143114556 A G 4 143114558 G A 4 143114598 G C 4 143129292 G A 4 143236139 T C 4 143236158 T C 4 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A 6 29759885 G A 6 29759923 T C 6 29759996 T C 6 29760029 G C 6 29760111 G C 6 29760149 G T 6 29760188 G A 6 29760510 G A 6 29760523 C T 6 29760536 G A 6 29760590 G A 6 29760605 G T 6 29795636 G A 6 29795657 G A 6 29796115 A C 6 29796152 G C 6 29796257 C T 6 29796306 G A 6 29796327 C T 6 29796749 C A 6 29796838 A G 6 29797173 A G 6 29797553 G C 6 29797639 C T 6 29855320 T G 6 29855386 C T 6 29855392 T C 6 29855392 T G 6 29855401 C G 6 29855409 A G 6 29855677 G A 6 29855682 T G 6 29855706 C G 6 29855733 C T 6 29855849 A C 6 29855856 T C 6 29855858 C A 6 29855901 A G 6 29855902 G A 6 29855940 G A 6 29855945 A G 6 29856092 A T 6 29856109 C T 6 29856199 A G 6 29856204 G T 6 29856655 G C 6 29856686 C G 6 29856693 C T 6 29856718 G C 6 29856965 G C 6 29857013 A G 6 29857021 C A 6 29857753 T C 6 29858218 A G 6 29858256 T G 6 29858294 A G 6 29858475 C A 6 29858476 T C 6 29858477 G A 6 29858517 A G 6 29858660 A C 6 29894128 C T 6 29894139 G A 6 29894205 T C 6 29894211 C T 6 29894226 G T 6 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G 6 29897417 G T 6 29897422 A G 6 29901640 C A 6 29901783 A T 6 29901806 C T 6 29901865 G C 6 29901898 C G 6 29901987 C G 6 29902005 G C 6 29902016 T A 6 29902040 A G 6 29902050 C T 6 29902051 A G 6 29902059 A G 6 29902063 C T 6 29902064 T G 6 29902074 A G 6 29902129 T G 6 29902130 G A 6 29902168 C T 6 29902198 A G 6 29902240 A C 6 29902293 C T 6 29902294 G T 6 29902327 G T 6 29902332 C G 6 29902333 A G 6 29902334 C T 6 29910057 C A 6 29910176 C T 6 29910189 A T 6 29911571 G C 6 29911604 C A 6 29911684 C T 6 29911685 C T 6 29911727 T C 6 29911790 T C 6 29911803 G A 6 29912614 C A 6 29912649 G C 6 29912656 C T 6 29912657 C T 6 29912668 T G 6 29912669 A G 6 29912680 A G 6 29912687 C T 6 29912713 C T 6 29913495 G A 6 29913518 C A 6 29913526 A G 6 29925127 G A 6 29925134 G A 6 29925438 C T 6 29974346 G C 6 29974500 A G 6 29975047 G T 6 29975453 C A 6 29975840 G A 6 29975950 C T 6 29975994 C A 6 29976024 C G 6 29976499 C G 6 29976741 A G 6 29977145 G C 6 30227397 C T 6 30227583 C G 6 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C 6 31239896 T C 6 31239937 C T 6 31323012 G A 6 31323020 T C 6 31323065 G C 6 31323567 G A 6 31323677 C T 6 31323707 G A 6 31323721 G C 6 31323725 T C 6 31323745 C A 6 31323766 T C 6 31323838 C G 6 31324003 T A 6 31324003 T G 6 31324004 C G 6 31324176 C G 6 31324184 C G 6 31324194 G A 6 31324200 G C 6 31324201 C G 6 31324206 G A 6 31324208 G T 6 31324210 G A 6 31324227 C A 6 31324229 G C 6 31324489 C A 6 31324489 C G 6 31324491 C A 6 31324499 C G 6 31324523 T C 6 31324530 G C 6 31324531 C G 6 31324531 C T 6 31324536 T A 6 31324536 T C 6 31324536 T G 6 31324538 G C 6 31324539 A T 6 31324542 T C 6 31324547 G C 6 31324829 G C 6 31324830 G A 6 31324847 C G 6 31324864 G A 6 31324887 G C 6 31324888 G T 6 31324891 C T 6 31324892 G C 6 31324895 G C 6 31324911 C G 6 31324921 C T 6 31324925 A G 6 31324931 A C 6 31324941 C T 6 31324953 C T 6 31324955 C T 6 31324996 G A 6 31324996 G C 6 31325004 G A 6 31333610 C T 6 31333731 T C 6 31333751 G A 6 31333820 A G 6 31333874 G A 6 31333911 C T 6 31333939 A G 6 31333963 T C 6 31334080 T A 6 31334120 A G 6 31487954 G C 6 31488038 C T 6 31488145 A G 6 32455520 G C 6 32455544 A G 6 32455560 G C 6 32455565 T G 6 32455566 T A 6 32455569 C T 6 32455577 A T 6 32455580 T G 6 32455585 T G 6 32455586 G A 6 32455588 T C 6 32455629 T C 6 32455644 T A 6 32455645 T C 6 32455651 A G 6 32455662 G A 6 32455668 A G 6 32455672 C T 6 32455680 G A 6 32455692 C A 6 32455718 T G 6 32455720 C G 6 32455725 A G 6 32455725 A T 6 32455726 C G 6 32455737 A G 6 32455742 T A 6 32455743 T A 6 32455743 T C 6 32455748 C T 6 32455750 C T 6 32455756 T A 6 32455757 A C 6 32455757 A G 6 32455777 C T 6 32455795 T G 6 32455801 C T 6 32455810 G T 6 32455812 C A 6 32455827 A G 6 32455828 T C 6 32455838 G A 6 32455839 T C 6 32455843 A G 6 32455847 A G 6 32455859 C G 6 32455877 A T 6 32455887 A G 6 32455901 T C 6 32455906 A G 6 32455909 T A 6 32455912 G A 6 32455917 C A 6 32455917 C G 6 32455928 T C 6 32455943 C T 6 32455952 T C 6 32455965 G A 6 32456028 G A 6 32796346 T C 6 32796480 T C 6 32798789 C T 6 32798795 C A 6 32805049 T C 6 32817130 A G 6 32819642 C T 6 32821859 C A 6 33290402 G A 6 33290825 A G 6 33290872 G A 6 34711946 C T 6 34712232 C T 6 35389999 G T 6 35420923 C T 6 35960390 C T 6 37001592 G A 6 37002182 G A 6 37709919 A T 6 38960253 A G 6 38960677 C T 6 38960750 C T 6 40419999 C T 6 41296173 C T 6 41296679 C T 6 41635569 G T 6 42407020 G A 6 43739327 C T 6 43742419 G C 6 43746949 T C 6 44228162 G A 6 44678620 A C 6 45969983 T G 6 46856100 G A 6 46856581 T G 6 47130819 T C 6 47130910 G A 6 47130988 A G 6 47713939 T A 6 47714073 G A 6 48151808 G A 6 48928482 A G 6 48928544 T C 6 49327632 T C 6 49328214 A G 6 51492164 T A 6 51514205 T C 6 51611344 A G 6 51619921 T C 6 51619972 A G 6 51637240 G C 6 51640787 A G 6 51655796 T C 6 51656388 A G 6 51696056 A G 6 51696074 G A 6 51701484 G A 6 51713012 G C 6 51735613 T C 6 51750961 G A 6 51752241 C T 6 51889099 A T 6 51897565 C T 6 51909525 T C 6 51919253 G A 6 51927666 T C 6 51927683 T C 6 51929476 T G 6 51934976 C T 6 51934978 A C 6 51936717 C T 6 51936723 G A 6 51940816 T C 6 51949862 A G 6 52529666 A C 6 52529714 C G 6 52530205 C T 6 53047564 C T 6 54610711 C T 6 54610742 A C 6 54610783 C T 6 54611146 A G 6 56291176 G A 6 58199238 T C 6 58250570 A T 6 58263871 T C 6 58269738 G A 6 58270343 C G 6 58403634 T C 6 58404193 C G 6 58522197 C T 6 61993928 G A 6 62864433 A G 6 62864516 G A 6 63083740 T G 6 63083748 G T 6 63083774 A G 6 65331854 T C 6 65589020 G C 6 66446642 A G 6 67044197 G T 6 67044321 C T 6 67044663 T A 6 67804122 G T 6 67804186 T C 6 67804194 A C 6 67804202 G A 6 71721412 G A 6 71721445 T C 6 72563207 C T 6 72563211 G T 6 72563750 C T 6 73888146 C T 6 75056542 G A 6 75877044 A C 6 76051990 A G 6 77478497 C G 6 78345710 C T 6 79426986 G A 6 79427089 A G 6 81484692 G C 6 81669149 G C 6 82074113 T C 6 83480639 C T 6 83480720 T C 6 83545840 C A 6 83546246 G A 6 85070849 C T 6 85071341 A G 6 85140178 A C 6 85140313 C A 6 85140399 G A 6 88608057 A G 6 90012435 G 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170529587 T C 6 170529638 T C 6 170530453 T C 6 170530506 C T 6 170530518 A G 6 170530559 T C 6 170530838 C T 6 170530873 C T 6 171026382 T C 6 171026394 T C 7 746314 A G 7 746705 A G 7 746706 C A 7 1883274 T C 7 2004124 C T 7 3155087 T C 7 3155089 T G 7 3155579 C T 7 3155651 C G 7 4320984 A G 7 4321571 A G 7 5156760 G A 7 5946901 G C 7 6013049 C G 7 6018444 A G 7 6018592 G A 7 6022178 G C 7 6029748 C T 7 6035428 A C 7 6035507 C T 7 6038483 G A 7 6039129 T C 7 6041897 T C 7 6042522 C T 7 6043057 A G 7 6043065 C T 7 6043112 C T 7 6045881 C T 7 6045934 T C 7 6048359 C T 7 6048804 G C 7 6048845 A G 7 6048973 C A 7 6414545 C T 7 6431404 G T 7 6431420 C A 7 6431933 C G 7 6441258 G A 7 6442371 G A 7 6776537 G A 7 6776585 C T 7 6777726 T C 7 6777752 T C 7 6777768 T G 7 6777780 T G 7 6777784 A G 7 6777820 T G 7 6777821 G A 7 6785956 A G 7 6786731 C T 7 6790900 T C 7 6791040 G C 7 6919565 T C 7 6974986 G A 7 6975272 G T 7 6975316 G T 7 6975366 C A 7 8549008 G A 7 8549058 G A 7 8549477 C T 7 10013659 G A 7 10897044 T C 7 10897594 C A 7 10897594 C G 7 11349162 C T 7 11349705 G A 7 11349733 A G 7 11349735 T C 7 12122025 C T 7 12510929 A C 7 12511312 G A 7 14868954 C T 7 16297567 C T 7 17006944 G C 7 17007526 G T 7 17514653 T C 7 18318662 C T 7 18624673 G A 7 18625440 C T 7 19184257 C G 7 21206385 A G 7 21764077 A G 7 21764081 G A 7 22327627 G A 7 22328109 C T 7 22947858 A G 7 22948438 G C 7 24353194 A C 7 24353195 C T 7 24353267 C T 7 25233745 C G 7 25233789 G C 7 26627952 G T 7 26627954 G A 7 29464865 T C 7 30177268 G A 7 30177278 C T 7 30855318 G A 7 30855926 G C 7 32133424 G A 7 32512110 A T 7 33101967 C T 7 33102514 G A 7 33193313 A C 7 33193314 T C 7 34540399 G T 7 35083870 T C 7 35084552 C T 7 35084572 C T 7 35084601 T C 7 36186371 G C 7 36858622 G A 7 36858643 A G 7 37415057 G A 7 37708712 A G 7 39807352 G A 7 40320747 G C 7 43874751 A G 7 44026116 T G 7 44056757 C T 7 44057222 C G 7 45256549 A G 7 45256975 A G 7 45828285 C T 7 45847880 A G 7 45856902 T C 7 45856916 G A 7 45857319 G A 7 45857848 G A 7 46028450 C T 7 46028459 C T 7 46643720 A C 7 50470256 G A 7 50745025 G A 7 51450917 G A 7 51450951 A G 7 51451225 T C 7 51451275 G A 7 51451291 C T 7 51451376 A G 7 51451655 G A 7 51451775 T C 7 51451925 C T 7 51451928 T C 7 51451955 G T 7 51452002 A G 7 51452050 G A 7 51452088 T C 7 51452279 A G 7 51824545 C T 7 51824890 T C 7 51824990 A G 7 52225367 T C 7 52758842 T C 7 52759429 A G 7 53189193 A G 7 53189634 G A 7 53190434 G T 7 53190453 A G 7 53190508 A G 7 53190917 C T 7 53203065 G A 7 53718464 T C 7 53718485 G T 7 53854735 T A 7 53854969 T C 7 54618943 A G 7 55210733 G C 7 55219290 T C 7 55219307 C G 7 55221447 C G 7 55225140 G C 7 55232726 G T 7 55248787 T C 7 55259948 C G 7 55658927 T C 7 55659085 T C 7 55806087 G T 7 55806093 G T 7 56405132 T C 7 56430969 C G 7 56430977 G C 7 56430980 C A 7 56431109 A G 7 56431170 A G 7 56431807 G A 7 56432242 T C 7 56635995 C A 7 57289345 C T 7 57603890 T G 7 57603918 G A 7 57669433 G T 7 57669986 A G 7 57809151 C A 7 57832849 T C 7 57938126 A G 7 57938210 T C 7 61058809 T G 7 61059081 A G 7 61063424 G A 7 61063551 A G 7 61071095 A T 7 61071103 C T 7 61071188 G T 7 61071203 C T 7 63206179 A G 7 63206611 A G 7 63206623 G T 7 63229281 G A 7 63229377 C T 7 63229524 T C 7 63230106 C T 7 63230147 C T 7 63230155 G A 7 63602429 G A 7 63602520 A G 7 63602542 T C 7 63635236 A C 7 63635239 G C 7 63635241 A G 7 63635248 T C 7 63635271 C G 7 63635272 T C 7 63635286 C T 7 64583576 C G 7 64583585 C T 7 64583587 C T 7 64583615 G C 7 64583628 C T 7 64652748 C G 7 64652982 T G 7 64653060 G A 7 65037658 C G 7 65037683 T C 7 65059071 A G 7 65082869 G A 7 65163375 C G 7 65163587 T C 7 65432962 G A 7 65552792 A T 7 65971428 G T 7 66355416 C T 7 66457975 T C 7 66458627 A G 7 66458631 C T 7 66458903 T C 7 66459513 C T 7 66459553 G C 7 66760853 T C 7 66760969 G A 7 66760975 C T 7 66761773 T C 7 66762050 A T 7 66762277 C T 7 66762340 A C 7 66762461 T A 7 67635408 C T 7 67635412 G A 7 69444431 G C 7 70047405 G A 7 71309437 C T 7 73809454 T C 7 74178770 C T 7 74193668 G A 7 74582543 T G 7 76072643 C T 7 76072644 A G 7 76237814 C T 7 76237885 A C 7 76364904 C A 7 76621710 C T 7 76641042 T C 7 76641340 A T 7 76669334 G A 7 78690736 C T 7 78690794 G A 7 79293866 A G 7 79293877 G T 7 80387473 G C 7 80387977 A G 7 80826781 T C 7 81346925 G A 7 81358712 G A 7 81381731 T C 7 81858825 G T 7 82925988 A G 7 83407638 A C 7 84345772 C G 7 84707925 C T 7 86856261 G T 7 87031809 A G 7 87133947 C A 7 87133993 T C 7 87149922 C T 7 87161049 T C 7 87174504 C T 7 87182882 T C 7 87190953 A G 7 87195106 C T 7 87195850 T C 7 87199264 C A 7 87199265 T A 7 87604085 A T 7 88195330 G A 7 88454877 G C 7 89641818 T C 7 89641833 G A 7 90158020 C T 7 90158026 C G 7 91509551 T C 7 92247112 C T 7 92300587 G A 7 92301040 C T 7 93194505 G A 7 93194506 C G 7 93194590 C A 7 97264891 C A 7 97264891 C G 7 97560579 G A 7 97561099 A C 7 97561130 C A 7 98648365 C G 7 99314986 A G 7 99738322 G C 7 101977547 A G 7 101977597 G A 7 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154453511 C T 7 154453688 G A 7 154453864 A G 7 154453902 T C 7 154453921 C T 7 154453928 G A 7 154454135 T C 7 154454180 G T 7 154454264 A G 7 154454268 G T 7 154454356 A G 7 154454435 A G 7 154454522 T C 7 154454523 G T 7 154454546 A G 7 154454616 C G 7 154454786 T C 7 154454939 A G 7 154454972 G A 7 154455363 T C 7 154455500 A G 7 154455674 C A 7 154915559 G T 7 154915599 A G 7 154915632 C T 7 154915894 T C 7 154916158 C T 7 154916681 G C 7 155126014 C T 7 155126074 G A 7 155126346 A G 7 155126421 C A 7 155126422 C T 7 155126626 C T 7 155126697 T C 7 155126714 A G 7 155126852 C T 7 155126903 C T 7 155127026 T C 7 155127061 A C 7 155127063 C T 7 155127076 G C 7 155127111 A C 7 155127142 T C 7 155127988 A G 7 155127991 G C 7 155128004 G C 7 155128005 A C 7 155128006 T C 7 155947955 G A 7 156781685 G A 7 157459940 T C 7 157459941 G A 7 157950927 T C 7 157950935 A T 7 157951445 A G 7 157951812 A G 7 157952182 G A 7 158248001 G A 7 158249548 C T 7 159001392 A G 7 159001393 G A 7 159001396 G T 7 159001399 A T 8 11386 T C 8 40370 A G 8 40565 C T 8 143930 T C 8 339174 G A 8 339319 T C 8 339338 G A 8 339668 G A 8 339702 C T 8 580564 T C 8 1292447 A C 8 1550886 C G 8 1550939 C A 8 1552096 A G 8 1552099 T G 8 2676199 C A 8 3415423 A C 8 3415633 G A 8 3415649 C T 8 3415650 C G 8 3848580 T C 8 3848627 C T 8 3848630 G C 8 3849139 C G 8 3849147 T A 8 4113196 G A 8 4650270 C T 8 5995309 A G 8 5995912 G A 8 6141844 T C 8 6141879 C T 8 6141887 C T 8 6946100 A G 8 6946189 A G 8 6946639 G T 8 6946666 C A 8 6946666 C G 8 6948229 C T 8 7000182 T G 8 7000202 C T 8 7000210 T C 8 7000238 A G 8 7070133 T C 8 7070315 A T 8 7192428 G A 8 7913763 C G 8 7913833 A G 8 7913965 A T 8 7913966 A G 8 8088230 T C 8 8094555 T C 8 8737464 T G 8 9165380 G T 8 11189344 C G 8 11607330 C T 8 11607352 C T 8 11607372 T C 8 11607377 A G 8 11607396 G A 8 11612315 C T 8 11612381 T C 8 11612929 A C 8 11614175 G T 8 11614225 G T 8 11993433 G A 8 11993450 G A 8 11993553 C T 8 11993854 C T 8 12285564 G A 8 12285923 C T 8 12466022 C T 8 12507122 G C 8 12517750 A C 8 12517757 G A 8 12517789 A G 8 12517792 A C 8 12517824 G T 8 12518207 T A 8 12518209 A G 8 12525951 T A 8 12526441 C G 8 12553656 A G 8 12553833 A G 8 12554019 C G 8 13282491 C G 8 14085219 C G 8 14085280 A T 8 14085785 T C 8 14085790 G A 8 15229407 G C 8 15230000 G A 8 15786119 A G 8 16421564 G C 8 16701281 T G 8 18074243 A T 8 18074261 G A 8 18080644 A T 8 18080651 A C 8 18080747 T G 8 18257795 C T 8 19319046 G C 8 19319062 G A 8 19319620 G A 8 19319625 G A 8 20918631 A G 8 21170053 A G 8 21171077 A C 8 21171170 T G 8 21696395 T G 8 21696441 G A 8 22068081 A G 8 24287864 G C 8 24593635 G A 8 26519881 G A 8 27325191 G T 8 27831553 T C 8 29398520 C T 8 29884966 C T 8 29886613 T C 8 30210844 A G 8 30939016 C G 8 30974348 G A 8 30989690 C T 8 31498589 G A 8 31948864 A G 8 32405979 T C 8 32406602 C T 8 32432753 G T 8 32474622 A G 8 32599851 C T 8 32617494 G A 8 32620467 A G 8 33282335 G A 8 33571231 G A 8 36952867 C T 8 36952918 A G 8 36953041 A G 8 38272542 C G 8 38272582 C A 8 38284994 C T 8 38286225 G A 8 38319729 A G 8 38804069 A G 8 39015793 T G 8 40574679 T G 8 48405604 A T 8 48649894 G A 8 49540066 G T 8 50732260 A G 8 51133527 G T 8 52152983 C T 8 53031404 A G 8 53851462 T C 8 53851506 A G 8 54068560 G A 8 54069239 G A 8 54446265 T C 8 54452476 C A 8 54573305 G T 8 54573308 G A 8 55379994 T G 8 55918430 T C 8 56866780 T C 8 56879113 C G 8 58085212 G T 8 58711370 G A 8 58711450 C G 8 59257315 G C 8 59337563 C T 8 59338856 G C 8 59736647 T A 8 62114861 G A 8 63055668 C T 8 63516587 G A 8 64183260 C A 8 64321899 T C 8 64322357 G A 8 66081707 G T 8 66081733 A G 8 66081764 G T 8 66502666 G T 8 67380377 C T 8 67380863 T C 8 68934648 A T 8 68965782 T A 8 68967824 A G 8 68968466 T G 8 68981646 T C 8 68981979 T C 8 68995205 A G 8 68995849 T G 8 69006214 A G 8 69046742 G A 8 69104278 C T 8 69104993 A G 8 69129636 A T 8 69130238 G A 8 69143417 C T 8 70174276 G A 8 71340692 T A 8 71974737 G T 8 72466982 T C 8 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C T 10 84158423 G A 10 84158433 A G 10 84158436 G A 10 84158972 T C 10 84473715 A G 10 86281312 G C 10 88651750 C T 10 89128565 C G 10 90232512 T C 10 91142901 T C 10 91570905 C T 10 96541373 A G 10 96602398 T A 10 96741426 C T 10 97759583 T C 10 97759626 A G 10 97760182 G A 10 97949901 C T 10 97990491 C T 10 98319855 A G 10 98320693 G C 10 98320932 A G 10 98510073 A G 10 99439541 G C 10 99439556 A C 10 99439901 G A 10 99972123 T G 10 100508702 C A 10 101341813 G A 10 104263675 T C 10 104268626 T C 10 104269301 G A 10 104374815 G C 10 104378563 G T 10 104378750 G A 10 107980644 T G 10 108496447 G A 10 108496455 C T 10 108497048 C T 10 109397974 A G 10 109398465 T C 10 110281465 C T 10 110998926 G C 10 111333728 A G 10 113752957 C T 10 113753002 T C 10 113753096 T C 10 114488065 G A 10 114591047 C G 10 115475804 A G 10 115548915 A T 10 115548971 T A 10 116006120 C T 10 116006247 T C 10 116180554 C T 10 117486391 G T 10 117810868 G A 10 118147645 A G 10 118147665 T C 10 118148153 A C 10 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C G 11 3439299 C T 11 3439368 G T 11 3439925 C T 11 3463826 T C 11 3463827 G A 11 3553733 T C 11 3592585 A G 11 3603224 G A 11 3605382 T G 11 3605415 T C 11 3605624 A T 11 3605644 T C 11 3605771 G A 11 3605773 C T 11 3913738 A G 11 4115974 C A 11 4128486 A G 11 4130621 A G 11 4132640 C A 11 4139978 T C 11 4142592 T C 11 4143692 T A 11 4143721 G T 11 4144842 A G 11 4144867 C G 11 4150101 T C 11 4153891 T C 11 4155132 C T 11 4156040 T A 11 4156106 G A 11 4159202 T C 11 4159225 A G 11 4159247 G A 11 4159252 C T 11 4159285 T C 11 5232146 G A 11 5232212 T A 11 6324678 T C 11 6325216 T C 11 6807468 A T 11 7449501 G A 11 7505088 C A 11 7505089 T C 11 8285124 A C 11 9682401 C T 11 10754380 T G 11 11331170 A G 11 11504981 C T 11 14274550 T G 11 14957663 G A 11 16334778 A T 11 17074520 G A 11 18288806 C G 11 18288948 G A 11 18289166 T C 11 18977418 A G 11 19865934 C G 11 20062121 T A 11 20062277 T C 11 20062704 C A 11 21484515 C T 11 21562629 G C 11 21563066 T C 11 22211249 A G 11 22646025 G A 11 22647550 A G 11 23039122 T C 11 23539200 C G 11 23539342 A G 11 23539753 C T 11 24396319 T C 11 25041687 T C 11 25041755 T G 11 25041811 A C 11 25041812 A G 11 25042243 G A 11 25042257 C T 11 27354842 C G 11 29754392 A G 11 32410337 C G 11 32457138 A G 11 33394460 T C 11 34251360 T C 11 34251855 G A 11 35425747 T A 11 36472800 A G 11 37145360 T C 11 38527379 G A 11 42748900 A T 11 42748986 T C 11 42748998 G A 11 43160505 T G 11 43536288 A G 11 44129086 A T 11 44151480 G T 11 44855872 G C 11 45123270 G A 11 46166591 G T 11 46450781 C G 11 46450821 G A 11 48453678 G A 11 48485877 T C 11 48599491 A G 11 48985441 T C 11 48985508 G C 11 49009877 T C 11 49080616 T C 11 49102685 G A 11 49103176 C T 11 49829781 G A 11 49829847 G T 11 49844161 C G 11 49844296 T G 11 49844746 G C 11 49844747 T C 11 49867489 A C 11 49867490 A C 11 49868030 A G 11 49868050 G C 11 49868051 G A 11 49878757 G T 11 49878885 T C 11 49878894 G A 11 49878896 A G 11 49878899 G C 11 49908279 G C 11 49908382 G A 11 49908392 C A 11 49908581 T C 11 49908583 C T 11 49908586 C A 11 49908592 A G 11 49908840 A G 11 49908856 A C 11 51483215 C T 11 51483747 G C 11 51515460 C T 11 51515640 A G 11 51516257 A T 11 54934563 C T 11 55035985 G A 11 55036233 C T 11 55049986 C A 11 55050558 T C 11 55071967 T G 11 55072428 C T 11 55532244 T C 11 55532303 T C 11 55532334 A G 11 55532908 A T 11 56517716 G A 11 60264755 G A 11 60265322 T C 11 60804962 G A 11 61456160 C T 11 61731977 G A 11 61773679 C T 11 62098295 T A 11 62914125 G A 11 63817799 G C 11 64574200 G A 11 65793121 C T 11 65793797 G A 11 67564437 A G 11 67564738 G A 11 67568487 C T 11 67570639 C T 11 67571091 T A 11 67714122 C G 11 67726415 G A 11 67931735 A G 11 67931761 G A 11 69457547 C T 11 69459046 A G 11 69465681 A G 11 70424188 G A 11 70857741 A G 11 71347185 T C 11 71349215 G A 11 71349372 G A 11 71349527 T G 11 71349654 G A 11 71349696 T C 11 71360446 G A 11 71399927 C T 11 71400609 T C 11 71477298 T C 11 71477335 C G 11 71502424 G A 11 71502531 G C 11 71502886 G A 11 71502930 A G 11 71506814 A T 11 71615069 G A 11 75432864 A G 11 75432886 G C 11 75432903 G A 11 76169644 A G 11 76170687 C T 11 76239148 G A 11 76239150 C T 11 76239160 A G 11 76250374 G A 11 76515087 G C 11 76515105 C A 11 77776590 G C 11 77777188 C T 11 78447534 T C 11 80555975 G C 11 80556380 T C 11 81258169 T C 11 81258185 C T 11 83261268 C T 11 83261334 C T 11 83261851 A G 11 83580202 A C 11 87079863 A G 11 88211600 T C 11 89487612 G A 11 89609220 T C 11 89609260 G A 11 89795691 G A 11 90372636 G A 11 90972900 C A 11 90973362 T C 11 90973418 G A 11 91680278 T C 11 92623608 A G 11 93754508 G A 11 94180115 G C 11 94200690 C G 11 94203353 G A 11 94213155 C G 11 94759059 A G 11 94782500 C G 11 94782501 A G 11 94782515 C A 11 95040632 C A 11 95041189 C A 11 95041230 C T 11 95532166 A G 11 95550810 C G 11 95561488 T G 11 95562771 T C 11 96852915 A T 11 97332219 G A 11 98998719 G C 11 99216940 T G 11 99217421 T C 11 99865248 A G 11 99865266 C A 11 99865868 T C 11 100921941 T A 11 101217386 A T 11 101217962 A G 11 101465270 A G 11 101981463 G T 11 101984628 C T 11 102079986 G A 11 102100199 C T 11 103416881 T C 11 103416913 T G 11 103542664 A G 11 104013175 A G 11 104013263 A T 11 105724696 C T 11 106318163 T C 11 106692416 G A 11 107669817 C T 11 107669894 C T 11 107670383 C G 11 107670446 A G 11 107670459 A G 11 108106782 C T 11 108158134 T C 11 108163733 A G 11 108165406 G A 11 108165407 C G 11 108170271 G A 11 108196509 G C 11 108204881 C T 11 110016032 A G 11 110016519 T G 11 110712255 A T 11 110712847 C G 11 114092153 C A 11 116732856 A G 11 117343197 T C 11 117956263 C T 11 117956338 G T 11 117956409 T C 11 117956943 A G 11 118362869 T C 11 118567444 A G 11 118567486 T C 11 119145274 A G 11 119167448 T G 11 119168370 G A 11 120440043 A G 11 120508093 C T 11 124455318 T C 11 125497247 T C 11 125497342 A G 11 125505095 C G 11 125507676 C T 11 126666122 C T 11 128240874 A T 11 128240927 G C 11 130416523 C T 11 130417076 G A 11 130417573 A G 11 131350351 C G 11 131350968 G A 11 134916463 G A 11 134916479 C T 11 134916495 T C 11 134917197 G A 12 420429 G A 12 427077 G A 12 433151 A G 12 442354 T C 12 443085 C A 12 443795 T C 12 460226 C T 12 461637 C T 12 464123 A G 12 471826 C T 12 474797 T C 12 494762 G C 12 528452 A T 12 528865 A C 12 528887 A T 12 530660 T A 12 530660 T G 12 1194236 A G 12 1194372 A G 12 1194777 A G 12 1196938 A G 12 1200335 G A 12 1899291 T A 12 3379076 G A 12 3567611 T C 12 4445722 G A 12 4553184 C T 12 5082261 A G 12 5082274 C T 12 5082302 A G 12 5082835 A G 12 5748011 T C 12 5748052 C T 12 5748078 A G 12 5748079 A G 12 6697842 A G 12 6704213 T A 12 7808545 A G 12 8387026 G A 12 8387543 C T 12 8391144 C G 12 8391162 T C 12 8391761 C T 12 8393255 G A 12 8393268 A G 12 8393274 T C 12 8393314 G A 12 8393803 C T 12 8544062 A G 12 8544083 G A 12 8544541 C T 12 8550134 C T 12 8552680 T C 12 9451473 G A 12 9451541 C A 12 9451818 T C 12 9585578 C T 12 9585658 A G 12 9848883 A G 12 10854878 A G 12 11174753 G A 12 11174795 T G 12 11201629 G A 12 11230403 T C 12 11230436 G A 12 11230437 A C 12 11230452 C A 12 11230457 C G 12 11230465 C T 12 11230496 G A 12 11230497 G A 12 11230520 G A 12 11230542 A C 12 11230544 C T 12 11230554 G A 12 11230566 G A 12 11230578 T C 12 11230583 T C 12 11230592 C G 12 11230597 G A 12 11230598 C T 12 11230601 C T 12 11230609 G A 12 11230636 T G 12 11230662 C T 12 11230665 G A 12 11230700 G C 12 11230701 G A 12 11230712 C T 12 11230726 C T 12 11230744 A T 12 11230752 T A 12 11230754 C T 12 11230775 A C 12 11230778 A C 12 11230832 A C 12 11230834 T C 12 11230867 T A 12 11230873 T G 12 11230890 C G 12 11230895 A T 12 11230909 A G 12 11230936 A T 12 11230948 A G 12 11230968 A G 12 11231002 C A 12 11231008 T C 12 11231018 G A 12 11231042 A G 12 11231052 G A 12 11611304 G A 12 11611331 C T 12 11611336 G A 12 11611368 C T 12 11611377 T C 12 12027745 A C 12 13370236 A C 12 13555619 G T 12 13555639 C T 12 13556252 G C 12 15138281 A G 12 16397411 A G 12 17757557 C A 12 20177190 C T 12 21616558 G A 12 21616598 C T 12 21617144 A G 12 21617145 A G 12 22193228 G A 12 22957461 A G 12 22957519 G A 12 23192806 T C 12 24358865 C T 12 25363085 C T 12 25368084 T C 12 26504062 C G 12 29688497 T C 12 30359821 T C 12 31242271 G A 12 31508019 G C 12 32741558 A G 12 33074174 A G 12 33074256 T G 12 37971347 G C 12 38600609 G A 12 40879387 A G 12 40880558 A T 12 40880586 A G 12 40880587 T A 12 40880831 A T 12 40880924 A G 12 40881916 T A 12 40881964 G A 12 40881967 C T 12 40881986 G A 12 40882000 C G 12 40882006 T C 12 40882016 G T 12 40882026 A G 12 40882071 C G 12 40882121 G T 12 40882450 G C 12 40882490 A G 12 40882522 C A 12 40882649 G T 12 40882701 G T 12 40883092 C A 12 40883745 C A 12 40883775 C T 12 40883781 G A 12 40883786 T A 12 40883904 G A 12 40884061 C T 12 42477389 T A 12 42477390 A C 12 42477397 A G 12 42477402 T C 12 42477404 T C 12 42477426 A G 12 42477431 C T 12 42477930 C T 12 42477945 A G 12 42477948 T G 12 42477951 T C 12 42477952 G A 12 42477962 C T 12 42477979 G C 12 42478001 T G 12 43965011 A T 12 43965108 T A 12 45228464 C T 12 46665157 G A 12 46955423 C T 12 51213765 T C 12 52698224 C T 12 52698226 A G 12 52698228 T G 12 52698230 C T 12 52698235 G T 12 52698236 C T 12 53346750 C T 12 53512756 A T 12 53512770 G T 12 54087418 C T 12 54476772 G A 12 54501012 G C 12 55828540 C T 12 56473808 T C 12 56474480 A G 12 56478002 A C 12 56481118 G A 12 56488913 G A 12 57489828 C T 12 57544620 C T 12 58141602 C T 12 60103232 G A 12 60553810 C T 12 61969925 T C 12 62524923 A G 12 62525409 A T 12 63503650 T G 12 64798118 C G 12 68551409 C T 12 68946720 C T 12 69202580 T G 12 69203312 G A 12 69207162 G A 12 69222357 C A 12 69230189 G T 12 70074807 G C 12 71520477 A C 12 71520600 T C 12 71521068 G T 12 72372601 C T 12 72979069 T A 12 72979099 T G 12 73501997 T G 12 76633769 T C 12 77056710 A G 12 79575315 T A 12 79575325 C A 12 82670236 C T 12 83471875 G A 12 83545935 C T 12 84356493 G A 12 85165573 A T 12 86084416 G T 12 87490519 G T 12 87490552 T C 12 88925973 T C 12 88939790 T C 12 88973732 A G 12 88974212 A G 12 89490962 T C 12 89491013 G A 12 89864432 T A 12 90270430 G C 12 91851148 T A 12 92997562 C A 12 94372056 C G 12 95012735 A G 12 95602672 C T 12 96161299 T C 12 96161309 G T 12 96161410 A T 12 96161868 G C 12 96161887 G C 12 96848128 C T 12 96848651 C T 12 96848682 A G 12 97799632 G A 12 97799634 C T 12 97800208 T C 12 97800239 C T 12 98984651 A G 12 98985056 T C 12 99265981 A G 12 99266022 A T 12 101215628 G A 12 102361086 T A 12 104959816 T A 12 105079958 T C 12 105673808 G A 12 106114632 G A 12 106620432 A G 12 107381892 C T 12 108168706 G A 12 109330915 G A 12 112241402 G A 12 112843998 A T 12 112856643 G A 12 112890776 A G 12 112942353 G A 12 114501664 T C 12 114501692 T C 12 114501693 G A 12 114501708 T A 12 114501726 C T 12 114501852 A T 12 114501869 A C 12 114501990 A G 12 114502105 T A 12 114502125 T C 12 114502197 T C 12 114502242 A G 12 114502276 A C 12 114502702 G T 12 115184053 G C 12 115866519 G T 12 116050988 C T 12 117193050 T C 12 117692072 T C 12 118256945 G C 12 118256995 T A 12 121426478 C T 12 121433816 C T 12 121433844 A G 12 121434833 G A 12 121876257 G T 12 121876385 G C 12 121876866 G A 12 122849392 A C 12 123186539 A G 12 123186610 G A 12 123186611 C G 12 123199745 T C 12 123199755 A G 12 124804371 G C 12 124804373 C T 12 124804522 A C 12 124804538 G A 12 124804550 C A 12 124804566 G A 12 124804578 C A 12 124804593 G C 12 124804644 A G 12 125177433 C T 12 125177454 G A 12 125177986 C T 12 127490326 A C 12 128958147 A G 12 129299134 T C 12 130876953 T C 12 130876961 G T 12 130876987 T C 12 130877140 G T 12 130877166 T C 12 130877287 G A 12 130877325 A G 12 130877332 G A 12 130877408 C T 12 130877506 A G 12 130877521 G A 12 131017991 C G 12 131966057 T C 12 131966293 C T 12 132286104 C T 12 132286105 G A 12 132286113 T C 12 132286133 G A 12 132957443 T C 12 132958490 A G 12 132959437 G A 12 132959439 G A 12 132959472 T A 12 132959689 C T 12 132959693 T C 12 132959732 T C 12 132961351 G T 12 133201947 T C 12 133208611 A G 12 133209593 T C 12 133209653 C T 12 133209660 G A 12 133212165 A G 12 133235577 A C 12 133241144 C A 12 133243788 T A 12 133243817 C T 12 133250569 T G 12 133250571 C T 12 133254529 C G 12 133255792 A C 12 133258088 C T 12 133818115 C T 12 133818696 G T 13 19098169 G A 13 19098189 T C 13 19196854 T C 13 19196952 A G 13 19196957 A G 13 19196999 A G 13 19197003 T C 13 19197028 A G 13 19197050 A C 13 19197108 G T 13 19197161 T C 13 19197162 G A 13 19312986 G A 13 19312997 T C 13 20006231 A C 13 21517666 C T 13 21535954 C G 13 22638746 G A 13 23269969 T A 13 23516337 C T 13 23533834 T G 13 23534184 T C 13 23534203 G A 13 23534230 C G 13 23534298 G A 13 24958840 C G 13 25244216 C G 13 25244691 C T 13 25535764 C G 13 25535765 A G 13 25535868 T C 13 26923565 T G 13 26974482 T G 13 27487175 G A 13 27487180 C T 13 27827811 C T 13 27945465 T G 13 28597187 C T 13 28601651 T C 13 28602604 T C 13 28609396 T C 13 28609399 G C 13 28610355 T A 13 28611630 T C 13 28644359 G C 13 28886388 A G 13 28893341 G C 13 28893870 C G 13 28896097 G A 13 28919330 G A 13 29007730 A G 13 30015342 A G 13 30015805 T C 13 30888324 T A 13 31276032 G C 13 31276586 G T 13 32421423 C T 13 32899567 G C 13 32900933 T A 13 32907767 C T 13 32921306 G A 13 32921362 T C 13 32945537 A T 13 32953182 A G 13 32968591 G A 13 32968607 A G 13 34723653 T G 13 34723667 C T 13 34724105 C T 13 34724194 C T 13 36108037 A C 13 37377469 T A 13 40733509 C A 13 40733531 A T 13 42300323 T C 13 43517113 C T 13 43517127 A G 13 43517700 G A 13 43517736 G T 13 44772757 A G 13 45626937 C T 13 47199611 T C 13 48273085 A G 13 48881154 G C 13 48919064 A G 13 48934575 A T 13 48954021 G C 13 50466615 G C 13 50466749 C G 13 50466754 T C 13 50466766 C T 13 50466771 A G 13 50466774 G A 13 50466780 C T 13 50466781 A G 13 50466783 C G 13 50935593 C T 13 51230621 A G 13 51231117 C T 13 51231132 G C 13 51685479 C T 13 51685541 C T 13 51686109 G A 13 52482451 G A 13 52602919 A C 13 60909992 G A 13 61266375 T C 13 61651695 T A 13 61652128 T C 13 62884880 A G 13 62885397 T C 13 62885404 C G 13 63984445 G A 13 63984474 C A 13 63984474 C T 13 63984519 T C 13 68406302 A G 13 68406306 A G 13 68406761 G A 13 68820749 C T 13 68820783 A G 13 69675780 G A 13 69675935 T C 13 70884365 C G 13 70884372 T C 13 70884412 G A 13 70884937 T C 13 70885012 C T 13 71158022 T C 13 71498321 T C 13 71498338 C T 13 71498343 G T 13 71498360 G C 13 71498385 C T 13 71498894 A G 13 72477265 C T 13 74077481 C T 13 74549292 T C 13 76333853 G A 13 76583319 A T 13 77614202 G A 13 77614206 A T 13 77614213 C T 13 78800795 G A 13 79015424 G A 13 79775160 C T 13 80384592 G A 13 80384594 A T 13 82485701 G A 13 82641070 G T 13 83720107 C G 13 85714107 T C 13 87209806 G T 13 88275166 G T 13 90617118 T C 13 90617599 C T 13 91023515 C A 13 91779179 A C 13 93036880 A C 13 94062095 C A 13 94996400 G A 13 95538615 C G 13 97843293 G T 13 98419205 T C 13 98522674 A T 13 99464351 T A 13 100477134 C A 13 100477148 A G 13 100545068 C T 13 101182148 A G 13 101987034 A C 13 101987047 A G 13 101987123 A G 13 102057883 A C 13 102058361 G A 13 103498375 T C 13 103520251 T C 13 107853969 G T 13 109006433 A G 13 109006441 T C 13 110418135 C T 13 110418136 G A 13 110419404 C T 13 110976837 A C 13 111132947 G A 13 111133395 C T 13 111133399 A G 13 111133489 A G 13 111133579 G A 13 111133625 T A 13 111133639 G A 13 111133665 C T 13 111133669 A G 13 111133835 A T 13 111134015 A T 13 111134119 A G 13 111589152 G A 13 111589204 G C 13 111589278 G A 13 111590028 A G 13 111590550 A G 13 111590930 C T 13 111591170 G A 13 111591265 G A 13 111591283 T C 13 111591853 G A 13 111592285 A G 13 112802383 G A 13 112802389 G A 13 112803722 T C 13 112803822 G C 13 112803840 A T 13 112803842 A G 13 112803853 T G 13 113498860 C T 13 114089046 C T 13 114089082 C T 13 114089113 A G 13 114089128 T C 13 114089164 C T 13 114089330 G A 13 114089440 G C 13 114089675 G T 13 114089876 A G 13 114089888 T C 13 114089891 A G 13 114089897 C T 13 114090025 C T 13 114090109 C T 13 114090253 T C 13 114090689 G A 13 114091321 T C 13 114838339 C T 14 19491761 T C 14 19629734 C G 14 19688223 G A 14 19688480 G C 14 20084306 C T 14 20084444 G C 14 20086576 G A 14 20140628 C G 14 20140803 G C 14 20140905 C T 14 20414407 C A 14 20414410 T C 14 20414737 C T 14 20414884 G A 14 20811577 A C 14 20811577 A G 14 20811578 A G 14 20811588 T C 14 20812951 G A 14 20815313 A G 14 20822772 C T 14 20826243 A C 14 21236526 T C 14 21237137 G A 14 21630781 C T 14 21860360 G A 14 21863716 C T 14 21871999 T G 14 21875487 T C 14 21894526 T C 14 22320158 C A 14 22320728 T C 14 22371221 G T 14 22371246 A G 14 22746792 C T 14 23029407 T C 14 23029409 T C 14 23029512 G C 14 23029525 A T 14 23652708 T A 14 24436511 T C 14 24436706 G C 14 24436798 G T 14 24473786 C A 14 24526287 G C 14 24526895 G A 14 25515815 A G 14 25515822 T C 14 26605655 T C 14 27314804 C T 14 27855023 T C 14 27855025 C T 14 31919287 T C 14 36351085 G A 14 36417424 G A 14 36417426 T A 14 36417451 G A 14 36417453 T A 14 36417478 A G 14 36417480 A T 14 36417498 T C 14 36417545 C T 14 36417546 A G 14 36417559 G A 14 36417572 T C 14 36417640 G A 14 36417696 A T 14 36417716 T C 14 36417723 A T 14 36417741 T C 14 36417743 T C 14 36417761 C T 14 36417777 A T 14 36417802 A G 14 36417804 A T 14 36417842 T C 14 36417883 A G 14 36417957 T C 14 36417959 T C 14 36418031 T C 14 36418355 T C 14 36419122 C A 14 36419133 T G 14 36989596 A G 14 36989696 G T 14 38639257 C T 14 39354900 C G 14 39858941 A G 14 41413712 C T 14 42835190 G A 14 45027200 G T 14 46316764 A G 14 47492399 C G 14 47562483 T A 14 48921178 T C 14 50520782 A G 14 52229607 C G 14 52229678 T C 14 52230158 T G 14 52519254 A G 14 52519839 G A 14 55880730 A G 14 55880918 A G 14 55921280 A G 14 56232970 T C 14 56233561 G A 14 56548918 C A 14 57463704 G A 14 57586697 C T 14 57586731 T G 14 59170024 C G 14 62003902 C T 14 62983672 A T 14 65473196 G A 14 65568563 C T 14 65733329 A T 14 65733701 A G 14 65734110 C G 14 65734181 C G 14 65734600 G A 14 65934921 T C 14 68291907 G A 14 68352323 A G 14 68354152 C T 14 68758317 T C 14 68934690 A G 14 68944147 T G 14 68944245 T C 14 70440081 T C 14 71632622 C T 14 71632640 C T 14 72266238 T A 14 72736899 G A 14 73047284 A G 14 73997686 G A 14 74025873 A T 14 75506875 G A 14 77101088 A G 14 77704974 G C 14 78149486 T C 14 78149563 G C 14 79217473 C T 14 80002042 A G 14 80002096 T C 14 80002632 A G 14 80874274 A T 14 81554617 A G 14 81558640 C G 14 81559221 G A 14 81562808 A G 14 81606422 G T 14 81606503 T C 14 81610869 C A 14 81610942 C T 14 82053802 T C 14 82054300 G T 14 82602590 C T 14 82603182 C T 14 86166491 A G 14 88199938 T C 14 91507280 T C 14 94339436 C G 14 94845040 G A 14 95389462 A G 14 95582544 A C 14 95600006 G C 14 95600072 T G 14 96092282 C T 14 96592735 C G 14 97107413 G A 14 98485583 T C 14 98486120 G A 14 98868717 G A 14 100595278 T A 14 100595880 G A 14 101134984 G A 14 103050106 G A 14 103050397 C G 14 103840494 G A 14 104168701 C T 14 104563874 C T 14 104563932 G T 14 104564283 T C 14 104564345 G A 14 104564410 T C 14 104564412 G A 14 104945518 C G 14 104945694 A T 14 105243435 G T 14 105246872 A G 14 106049449 T C 14 106167913 T A 14 106725276 G A 14 106725315 G A 14 106725329 C T 14 106725339 A G 14 106725346 G A 14 106725515 A C 14 106725525 C A 14 106725526 T A 14 106725543 A T 14 107046720 T A 14 107048702 G A 14 107048749 C G 14 107048929 T C 14 107112165 C G 14 107112665 A C 14 107130943 G A 14 107130971 C T 14 107131063 A G 14 107131164 A C 14 107131246 C T 14 107131290 T C 14 107131300 T C 14 107131301 C G 14 107131349 A G 14 107131357 T C 14 107131410 A G 15 20148695 G T 15 20148878 C A 15 20319405 C T 15 20319448 T C 15 20543982 T C 15 20543988 A G 15 20635860 C T 15 20891413 A C 15 20891478 C T 15 20891489 T C 15 20891547 C T 15 20891566 C A 15 20891566 C G 15 20891651 A G 15 20891867 G T 15 20891893 C A 15 20966938 G T 15 20967029 A G 15 21136727 T A 15 21136951 G A 15 21136968 C T 15 21137321 C A 15 21325716 C T 15 21325857 T C 15 21326120 C T 15 21326788 C G 15 21966878 C T 15 21973528 C T 15 21973529 A G 15 21973572 T C 15 21973587 T C 15 21973588 A G 15 21973592 G T 15 21973797 T C 15 21973842 A C 15 21973843 G A 15 22148127 C T 15 22148775 A G 15 22148845 A G 15 22151298 C T 15 22151704 A G 15 22151876 C T 15 22822510 G C 15 22822568 T G 15 22822751 C G 15 22822755 G A 15 22822854 T A 15 22822955 G T 15 22823001 T A 15 22823078 A G 15 22823113 T C 15 22823116 C A 15 22823137 A C 15 22823185 T G 15 22823255 A C 15 22823692 T C 15 22823783 G T 15 22823838 C A 15 22823855 A G 15 22823949 C A 15 22823963 T C 15 22824021 T G 15 22824030 C A 15 22824086 G A 15 22824376 A G 15 22826375 T C 15 22826634 A C 15 22826679 C T 15 22826764 T C 15 22827002 G C 15 22827233 A G 15 22827239 G C 15 22827251 A C 15 22827293 C A 15 22827319 G T 15 22827322 A T 15 22827437 A G 15 22827816 A C 15 22827928 T G 15 22827930 C A 15 22827939 T C 15 22827984 G C 15 22827985 G A 15 22828037 G A 15 22828041 A G 15 22828139 A T 15 22828145 T C 15 22828147 T C 15 22828275 G C 15 22828390 A T 15 22828465 A C 15 22829674 C G 15 22829687 G T 15 22829695 C T 15 22830185 T C 15 22830340 C T 15 22830453 G A 15 22830504 T A 15 22830510 G T 15 22830571 C T 15 22830577 A G 15 22830592 G T 15 22830847 C G 15 22830891 T C 15 22830899 G T 15 22830903 G C 15 22830990 C T 15 22830999 C T 15 22832977 A G 15 23782545 T C 15 24059444 T A 15 24059493 A T 15 24060123 T G 15 24060127 G A 15 24506371 C A 15 24506572 C T 15 24672192 G T 15 24672267 G C 15 24672440 G C 15 24672460 A C 15 24672460 A T 15 24672504 G C 15 24672554 G T 15 24672804 T A 15 24722807 G T 15 24722823 G C 15 24722829 G A 15 25414653 C T 15 26273690 G A 15 26274261 A G 15 26600681 A G 15 26601246 G A 15 26601264 G A 15 29717391 T C 15 31490709 A C 15 31821275 G A 15 32535526 G A 15 34638030 C T 15 34639823 A G 15 34639826 A G 15 34639879 C G 15 34639904 G A 15 35147136 C A 15 35147592 G A 15 35384908 C A 15 37292823 G A 15 37292836 G A 15 38190654 G T 15 38545725 A C 15 38617282 A G 15 38642971 G C 15 38643009 G A 15 38643031 C T 15 39034864 C T 15 39034914 G A 15 40457042 A C 15 40457635 C T 15 40998305 T A 15 41011311 G A 15 41021280 C G 15 42265586 G A 15 43853068 C A 15 43853127 C T 15 43853145 G A 15 43853167 T C 15 43853196 C G 15 43853216 T A 15 45985719 G C 15 47150907 T C 15 49220457 A G 15 49615149 A G 15 51483996 G C 15 53022863 A C 15 53023345 C T 15 53178383 C G 15 54607264 T C 15 55099758 G T 15 59722664 C T 15 59844728 A G 15 59845138 G A 15 62046728 T C 15 66736741 C T 15 66774559 A G 15 67458930 C T 15 67476735 G A 15 67476756 C T 15 67476768 C T 15 67477450 C T 15 68123700 C T 15 69383465 T A 15 69676000 C A 15 70292710 C T 15 70573650 C A 15 71967893 G A 15 74460734 C T 15 74654146 T C 15 76001037 C T 15 76039262 T C 15 78206482 C T 15 78206514 A T 15 78206928 G A 15 78206970 G T 15 78206973 C A 15 78207027 A G 15 79032355 T C 15 79032469 C T 15 79155412 T C 15 79526411 G T 15 80012735 A G 15 81410106 G A 15 82636963 G A 15 82637357 T C 15 83331487 T C 15 83569832 C G 15 84143244 G A 15 84857013 C G 15 84909385 G A 15 84951508 C A 15 84951578 G C 15 85052414 C T 15 85495400 C T 15 85495950 C T 15 85788238 G A 15 85788607 C T 15 85788735 T C 15 86855520 G A 15 88428702 C A 15 88472170 A G 15 88483594 A G 15 88680100 G A 15 88680987 T A 15 88690951 C T 15 88726405 G A 15 88727751 A T 15 89801677 G C 15 89811482 T C 15 89821732 G A 15 89824258 A C 15 89833165 T C 15 89836793 C A 15 89843950 A T 15 89855998 C T 15 89859377 A G 15 90628777 T C 15 90631247 G A 15 90633416 A G 15 90645265 G A 15 91290366 G C 15 91337208 G A 15 91347135 C A 15 91347755 A G 15 91347784 C T 15 91352774 A G 15 91969961 G C 15 91969970 T G 15 91969976 C G 15 92868324 A G 15 94208914 A C 15 95270619 C T 15 95270626 T C 15 95271164 T A 15 95662895 T A 15 96479346 C T 15 96705724 T C 15 97586395 C A 15 98419797 C A 15 98419885 G C 15 99434357 G A 15 99443139 G A 15 99443161 A G 15 99454245 A G 15 99454962 C T 15 99454994 G A 15 99458902 C T 15 99482903 C T 15 99485931 T A 15 99491540 G A 15 99500064 C T 15 100285424 T G 15 100333593 G A 15 100339833 G C 15 100339897 T C 15 100339938 C T 15 100340316 A C 15 100340375 A G 15 100340413 C T 15 100340484 A G 15 101110096 T C 15 102296008 G C 15 102296140 C T 15 102296231 C T 15 102300354 T C 15 102301640 T C 15 102301662 A C 15 102301669 G C 15 102303340 A G 15 102303423 A G 15 102303495 C A 15 102303519 G T 15 102304191 G C 15 102305129 T C 15 102305169 G T 15 102517868 G A 16 326817 C A 16 326826 C G 16 900140 A G 16 1872922 C G 16 1873332 G A 16 1873372 C T 16 2107489 C T 16 3020860 C G 16 3799857 T C 16 3828348 A G 16 4060980 T C 16 4985044 C T 16 5139217 C G 16 5143432 C G 16 5143976 C G 16 5145474 C T 16 5145847 G A 16 5145848 A G 16 5145883 A G 16 5146062 C G 16 5166093 A G 16 5338275 A G 16 5338313 C G 16 5527601 T A 16 6553772 G A 16 6554204 A C 16 6554253 C A 16 6554268 C T 16 7495752 C T 16 7496375 G T 16 8603974 A G 16 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C T 16 78082906 G A 16 78761364 A G 16 78761917 G C 16 79161532 A C 16 79704152 T C 16 81636255 A G 16 81636851 G A 16 82150582 A G 16 82527841 C T 16 83459041 C T 16 83691187 G A 16 85437616 T C 16 85437625 T C 16 85437629 G A 16 85437709 G A 16 85437722 T C 16 85437742 T C 16 85437752 A T 16 85437996 A T 16 85438220 G A 16 85438556 T A 16 85438649 A G 16 85438680 C T 16 85438700 C T 16 85441380 C G 16 85441405 G C 16 85441424 T C 16 85441812 A C 16 85442570 T C 16 85442574 A G 16 85443843 T C 16 85443876 G A 16 85443989 T G 16 85444082 G C 16 85444102 C A 16 85444107 C T 16 85444130 T C 16 85444204 C T 16 85444618 A G 16 85444655 A C 16 85444705 T C 16 85444849 A C 16 85445141 C T 16 85445267 C G 16 85445365 C T 16 86005933 C G 16 86005964 T G 16 86005984 G A 16 86006286 C T 16 87178517 A G 16 87179026 T C 16 87179050 G T 16 87179063 G A 16 87179102 G A 16 87179142 G A 16 87179180 C A 16 87648305 C T 16 87648315 T G 16 87648341 G A 16 87926558 G A 16 87926696 G C 16 88073139 C T 16 88073194 C T 16 88073218 T C 16 88073296 A G 16 88310744 C T 16 88310829 T C 16 88310830 G A 16 88310910 A G 16 88310955 A G 16 88310963 C G 16 88311269 A G 16 88311279 A T 16 88311285 A T 16 88311291 G C 16 88311355 T C 16 88312367 C T 16 88312750 C T 16 88312754 A G 16 88312962 C T 16 88312973 C T 16 88313227 C T 16 88313229 C T 16 88313255 A G 16 88313383 A G 16 88313402 T C 16 88313449 T C 16 88313454 T C 16 88313493 A G 16 88313505 A G 16 88313530 G T 16 88313585 A G 16 88313677 C T 16 88313845 C T 16 88794959 C A 16 88795086 T G 16 88795431 A T 16 88795433 C T 16 88795718 C T 16 89299506 A T 16 89299519 G C 16 89299899 A G 16 89756171 G A 16 89756185 A T 16 89806732 G A 16 89807543 G A 16 89808939 T C 16 89809548 C A 16 89809549 A G 16 89811151 A G 16 89811209 C T 16 89811663 T C 16 89811751 C G 16 89814818 T G 16 89815321 C T 16 89815824 G A 16 89816569 C A 16 89818340 G C 16 89818908 C T 16 89828043 T A 16 89839976 T C 16 89842479 T C 16 89849735 G A 16 89849740 C T 16 89851004 A G 16 89851033 C T 16 89998794 G A 16 90233312 C T 17 164435 C T 17 164955 C A 17 164967 T C 17 164969 C G 17 164980 C T 17 164997 T G 17 164999 C G 17 165010 T C 17 165025 T C 17 165071 C T 17 165078 C A 17 165085 C T 17 165090 G T 17 165147 T C 17 165201 C G 17 165240 C G 17 165247 C T 17 165256 C A 17 165295 T C 17 165357 C A 17 165375 A C 17 165386 T C 17 165409 C T 17 165419 A C 17 165501 T C 17 165515 T C 17 165562 C T 17 165565 G C 17 165576 T C 17 165585 G T 17 165615 G T 17 165643 C A 17 165694 A G 17 165695 C T 17 165712 T A 17 165732 T C 17 165736 C T 17 165742 G C 17 165966 T C 17 165976 C T 17 166081 T C 17 166186 C A 17 166346 A G 17 1020183 G A 17 1020394 G T 17 1022697 C T 17 1022705 G T 17 1022734 G A 17 1022796 G C 17 1022860 G C 17 1022923 C T 17 2257864 A G 17 2258637 A C 17 3315757 T C 17 3315904 G A 17 3771365 A C 17 3771379 G A 17 3771380 T C 17 3771381 G A 17 3771384 C A 17 5033768 C A 17 5034469 G A 17 5043998 C T 17 5603793 C T 17 6461283 A G 17 7569698 A C 17 7573229 C T 17 7576348 C T 17 8107979 G T 17 8109598 G A 17 8113186 A G 17 9756002 G T 17 9756057 T C 17 9756171 A T 17 9756198 T C 17 10095727 T G 17 11355538 C T 17 11356161 A C 17 11356178 G A 17 11924471 C T 17 12042934 T A 17 12968947 T C 17 12969339 G T 17 15486857 G A 17 15486909 A G 17 16012494 A T 17 16068096 C T 17 16528031 C T 17 17120668 G C 17 17625022 A G 17 17625107 T C 17 17625185 G T 17 18297214 C G 17 18299435 C T 17 18299631 C G 17 18393867 C T 17 19486126 C T 17 19486133 T C 17 19486148 T C 17 19486537 A G 17 19486585 C A 17 19486592 T C 17 20451455 A C 17 20453878 G T 17 21262861 G A 17 21408378 T C 17 21503001 G C 17 21825993 T G 17 21826038 T C 17 21826256 A G 17 21859750 A G 17 21901935 C G 17 21901936 C T 17 21901945 G C 17 22213908 C T 17 25746737 C A 17 25747067 C T 17 25747244 C T 17 25748176 C A 17 25748270 G T 17 25982703 C T 17 25983153 G A 17 26079849 T C 17 26087967 T A 17 26087978 A T 17 26088432 C G 17 27536646 T C 17 28043613 G A 17 28883741 C T 17 29541339 A T 17 29558082 T C 17 29592550 T C 17 29675878 T G 17 29684553 C T 17 30389991 G A 17 32084335 G T 17 32980299 C T 17 32980342 C A 17 33520071 C T 17 33520663 C T 17 34416275 T A 17 34416946 G A 17 34488320 G A 17 34587938 T C 17 34587942 C T 17 34754758 G C 17 34754836 A C 17 36097775 G A 17 36102035 G C 17 36103872 C G 17 36221809 T A 17 36578907 C T 17 36579428 C T 17 37230242 T C 17 37626963 G A 17 37646589 T C 17 37650569 G A 17 38561366 T C 17 38568249 C G 17 39383335 C G 17 39394674 A G 17 39394729 C A 17 39394755 C A 17 39394787 C A 17 39394790 T C 17 39394807 C A 17 39394885 C T 17 39394911 A G 17 39406673 T G 17 39604697 A G 17 40490539 T G 17 40490559 G T 17 40498273 T C 17 40498944 T C 17 41199913 T C 17 41205772 G A 17 41212169 C T 17 41213626 G T 17 41213660 T C 17 41222723 T C 17 41230228 G A 17 41232698 C T 17 41248164 C T 17 41250923 T C 17 41257134 T C 17 41276348 T C 17 41310495 T C 17 41623212 G A 17 43057954 G A 17 43626858 C T 17 45095080 T G 17 45095092 G A 17 45095678 G A 17 46319546 G A 17 47696070 T C 17 47696933 C T 17 47696939 G A 17 47700315 G A 17 48899222 A G 17 49451714 A G 17 49451742 G C 17 49452209 A G 17 50762097 A G 17 50762653 G T 17 51901084 A G 17 51901643 C T 17 51901703 C G 17 52941883 G C 17 53573902 C T 17 53574374 G A 17 55426865 T C 17 56447952 G C 17 56773834 T C 17 58082363 C G 17 58082421 G C 17 58082431 G C 17 58174022 G A 17 59761706 A G 17 59878416 G C 17 59886310 T C 17 59934879 G C 17 60341389 G C 17 60341507 A G 17 60341507 A T 17 60350783 T C 17 60350874 C A 17 61963236 C A 17 61963241 A G 17 61963478 T C 17 61963622 A C 17 61978159 T C 17 61978548 A G 17 61978622 G A 17 62790430 G A 17 63532175 A G 17 63537898 T C 17 64914494 C T 17 65854602 C T 17 65855104 T A 17 66180139 C G 17 66180681 G C 17 66211771 G C 17 66211840 T C 17 66211969 T A 17 66212122 A T 17 66511299 C T 17 66518663 A G 17 66520427 C T 17 66520838 A G 17 66523772 G A 17 66524755 C T 17 67528431 G A 17 69034000 A T 17 71276883 C T 17 71978657 A T 17 71978747 G A 17 71979236 T G 17 71979237 T G 17 72005968 A G 17 72005970 A T 17 72623641 G A 17 74442413 T C 17 74442440 C G 17 74442942 A G 17 75557061 G T 17 75558122 T C 17 75558750 A G 17 75558782 A T 17 75558791 A C 17 75558802 C T 17 75558814 C T 17 75559019 C T 17 76168857 G T 17 76608673 A G 17 78299319 T C 17 78519169 G A 17 78704156 T C 17 78728314 G A 17 78765080 A C 17 78795868 A G 17 78820023 T C 17 78820212 G A 17 78829531 C T 17 78831983 C T 17 78854056 A G 17 78854487 A G 17 78854496 C T 17 78867906 G A 17 78867951 G C 17 78882953 G A 17 78882972 A C 17 78897056 C G 17 78897732 C T 17 78897733 T A 17 78919285 A G 17 78919324 G A 17 78919349 A G 17 78919387 G A 17 78919837 G C 17 78919859 G C 17 78920807 A G 17 78922952 C G 17 78923007 T G 17 78935071 G A 17 78937165 G A 17 78937925 C T 17 78938011 C A 17 80107354 G A 17 80108414 T C 17 80108478 A G 17 80108696 C T 17 80108822 C T 17 80108842 T C 17 81024201 C T 17 81024331 G A 17 81024640 C A 17 81024656 G A 17 81024660 T C 17 81024673 C T 17 81024674 C G 17 81024677 A C 17 81024682 T G 17 81024691 A G 17 81024707 C T 17 81024731 A G 17 81024741 G A 17 81024752 A C 18 13754 A T 18 43439 A T 18 43535 A C 18 43538 T C 18 86837 T C 18 86857 T C 18 657352 T C 18 657443 A C 18 657458 A G 18 657474 T C 18 658035 A G 18 1963905 A G 18 2913896 C G 18 2913918 G A 18 3406591 A G 18 4106340 T G 18 4106917 G A 18 4932957 C T 18 4933515 C T 18 4933516 G A 18 4933518 T G 18 6462081 A C 18 7382800 A G 18 7382881 C A 18 8408675 G A 18 8789233 G A 18 11610464 G T 18 11610468 A G 18 11610624 G C 18 11610630 G A 18 11610763 A G 18 11618008 G A 18 11622851 T C 18 11623045 T C 18 11623100 C T 18 11644581 G A 18 11644667 G A 18 11644679 G T 18 11644723 T C 18 11644746 G A 18 12101808 G A 18 12898367 A G 18 13369940 C T 18 13370544 G A 18 13673746 C T 18 13674057 A G 18 13674212 C A 18 13674777 T C 18 13675072 A G 18 13675437 T C 18 13675449 A T 18 13675457 G C 18 13675494 C T 18 13675799 A T 18 14341320 T C 18 14341763 T C 18 14436696 C A 18 14524300 T C 18 14594781 C A 18 14595105 A T 18 15165336 A G 18 15165362 G T 18 15206879 C T 18 19761756 C A 18 19995753 T C 18 21252592 A G 18 21978687 A G 18 22598696 C T 18 23785015 C A 18 23785095 C T 18 23785115 C G 18 23883026 G C 18 23883058 T C 18 24885804 T C 18 26757855 T C 18 27273833 C T 18 27587457 A G 18 28115656 T C 18 28115679 C G 18 28115710 C T 18 28115783 G A 18 28115955 G T 18 28116070 G A 18 29573525 T C 18 31662955 C T 18 33187675 G C 18 33187676 T G 18 33187692 A G 18 34886895 T G 18 34887449 G A 18 34887505 A G 18 35451056 C T 18 36001103 G C 18 38530356 A G 18 39614110 G A 18 39620376 T A 18 39620932 G A 18 39620950 C T 18 40049623 G A 18 40050171 T C 18 43006049 C T 18 44223365 G T 18 44909077 A G 18 44909081 G A 18 45368587 G A 18 45371445 C T 18 45371509 C T 18 45377882 G C 18 45395111 G C 18 45651984 C G 18 46453156 A T 18 46453754 C T 18 47701550 T C 18 48581601 C A 18 48603403 T C 18 49958403 G C 18 49959036 G T 18 51674135 A G 18 54762024 G A 18 55396242 G A 18 55782772 T C 18 56757385 T C 18 56757399 A G 18 56757422 T C 18 59992577 T C 18 59992591 C G 18 60015207 G C 18 60015750 G A 18 60026926 C T 18 60026931 G C 18 60027005 T A 18 60028762 G A 18 60029238 G C 18 60029281 A G 18 60029292 G A 18 60034276 C T 18 60984964 C A 18 61654297 A G 18 63196837 G A 18 65928322 A T 18 66103401 C T 18 67182508 G T 18 67182512 G A 18 67183000 A G 18 67183043 T C 18 68086329 G A 18 68086404 A G 18 68086457 T G 18 68086460 C T 18 68700027 G A 18 69291422 G A 18 70066366 G A 18 70592333 A G 18 70592333 A T 18 70592352 A G 18 70592858 T C 18 71467330 G C 18 71640426 G A 18 72226809 C A 18 72226857 T C 18 73300822 T C 18 74757060 T G 18 74757768 A G 18 76394226 C G 18 76798551 G A 18 76798812 C T 18 76798870 A T 18 76799194 T C 18 76799227 A G 18 76799231 C T 18 76799232 T G 18 76799233 G C 18 76799233 G T 18 76799237 G A 18 76799276 C T 18 76799300 G A 18 76799500 C T 18 77378236 C A 18 77378238 C G 18 77378242 G A 18 77378897 C T 18 77378974 C T 18 77379017 C T 18 77379036 C A 18 77379117 T C 18 77379177 T C 18 77379214 C T 18 77379461 T C 18 77379462 C A 18 77379462 C G 18 77379473 T C 18 77379566 T C 18 77379577 C T 18 77379578 C G 18 77379589 T C 18 77379649 T C 18 77379742 T C 18 77379754 C G 18 77379765 C G 18 77379814 C G 18 77379845 C T 18 77379922 T C 18 77379994 C G 18 77380025 T C 18 77380053 G C 18 77380053 G T 18 77380442 C T 18 77380579 C T 18 77380810 A G 19 1218219 C T 19 1218771 G A 19 1219129 G A 19 1219702 G A 19 1222316 C T 19 1226901 G T 19 2180515 G A 19 2185651 C T 19 2186237 G A 19 2190774 T A 19 2194896 T C 19 2199576 C T 19 2207041 A G 19 2207452 G A 19 2208859 T C 19 2210269 C T 19 2221792 T C 19 2833802 A G 19 2833864 G A 19 3110585 A G 19 3113770 T C 19 3113780 C T 19 3113839 A G 19 3115402 C T 19 3118638 C T 19 3120739 T G 19 3148819 G T 19 4094110 G T 19 4094775 G A 19 4098947 G A 19 4102132 A C 19 5524721 C T 19 6230241 G A 19 6495064 C G 19 6495079 G 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19261833 A G 19 19261851 T C 19 19664077 C T 19 20024912 T A 19 20024959 G A 19 20050037 G A 19 20162695 A C 19 20162824 G C 19 20632050 T C 19 20632172 T G 19 20632400 T C 19 20832195 C T 19 20857905 T C 19 21057335 G A 19 21148018 G A 19 21148051 C G 19 21148086 G T 19 21749035 T C 19 21749580 C T 19 22155757 G A 19 22642684 T C 19 23477341 C G 19 23477350 C G 19 28330492 T C 19 28330539 A G 19 29331628 C A 19 29331703 C G 19 29518038 G C 19 30303352 T C 19 30311372 C T 19 30314371 G A 19 34080511 G C 19 34080579 C G 19 34882578 G A 19 36213072 A G 19 36217957 A G 19 36219420 G A 19 36219525 A G 19 36222017 A G 19 36222023 T C 19 36224973 T C 19 36807142 A G 19 36807249 A T 19 36807297 T G 19 36807306 G A 19 36807345 G A 19 36807347 G A 19 37147049 A G 19 37147639 C T 19 37752858 C T 19 37752861 T C 19 37752862 G A 19 37753071 T C 19 37753073 T C 19 37753239 G A 19 38391602 C A 19 38932157 C T 19 39261999 C T 19 39990995 G A 19 39991023 G A 19 39991614 A G 19 39994023 A G 19 39994513 G A 19 39997472 G A 19 40739513 A G 19 40743523 C T 19 40770860 G A 19 41349550 G C 19 41349640 G C 19 41349978 A G 19 41353107 T C 19 41353849 C T 19 41381310 A G 19 41381334 G A 19 41382180 G C 19 41384067 T C 19 41384084 T C 19 41384102 G T 19 41384385 T G 19 41384386 C G 19 41385734 C T 19 41386527 G A 19 41386544 C G 19 41386547 G C 19 41386584 G T 19 41386622 C T 19 41387241 G A 19 41414363 A T 19 41415087 G A 19 41415112 T A 19 41415818 G A 19 41416072 G C 19 41416143 C T 19 41416260 T G 19 41416263 C A 19 41416264 A G 19 41512415 T C 19 41515018 G A 19 41529956 A G 19 41600800 C T 19 41600808 C T 19 41736661 G A 19 41744831 C T 19 41745930 C T 19 41754217 G T 19 41765229 T C 19 43359392 G A 19 43383004 G C 19 43421318 C T 19 43440900 T C 19 43586183 T C 19 43586267 C T 19 43586408 A G 19 43690192 T A 19 43772788 C G 19 43773287 G C 19 43773303 T C 19 43860030 G A 19 43860048 G T 19 43860053 G A 19 43860076 C T 19 43860192 T G 19 43882832 A C 19 43882836 C T 19 43882895 A C 19 43883013 C A 19 43883124 C T 19 43883126 G A 19 44055898 C T 19 44056052 A G 19 44057227 T C 19 44057276 G A 19 44905282 C G 19 44905683 C T 19 44905779 C T 19 45862449 A G 19 45868649 C G 19 45871606 T C 19 45916587 T C 19 45924038 G A 19 46375779 C T 19 46406242 A G 19 46721467 G A 19 48764695 G A 19 48764721 T C 19 48765117 G A 19 49457938 A G 19 49458570 T C 19 49459876 T A 19 50265230 C T 19 50901893 G A 19 50903004 A G 19 50909107 C A 19 50920959 G T 19 51315061 T C 19 51315132 T C 19 51315175 T C 19 51315251 C T 19 51646187 C A 19 52249947 C G 19 52249959 G T 19 52704961 T C 19 52709064 G T 19 52714353 T A 19 52715716 G A 19 52718799 C T 19 52718816 C T 19 52718884 T A 19 52720262 A G 19 52723930 C T 19 52724027 C A 19 53927121 A C 19 53927131 C A 19 53927136 A G 19 54007749 G C 19 54208058 T C 19 54267981 C T 19 54860836 G A 19 54860845 A G 19 54860961 G A 19 54860964 A C 19 54860970 T G 19 54861346 G A 19 54861759 G T 19 55271654 C G 19 55333096 T C 19 55333246 C T 19 55350666 C A 19 55350713 G C 19 55350754 A G 19 55350948 A T 19 55350979 A G 19 55351022 A C 19 55543973 C T 19 55544430 A G 19 55544687 G A 19 55544750 A G 19 55545139 A G 19 55545191 G T 19 56361176 A G 19 56361263 G A 19 56361279 A G 19 56361479 A G 19 56361733 T G 19 56361758 T A 19 56361933 G T 19 57866239 C A 19 58464742 G C 19 59051326 T C 19 59051337 G C 20 402053 G A 20 402440 A G 20 928228 T C 20 1496279 A G 20 2367161 C T 20 2367209 T C 20 2545011 T C 20 4040209 G T 20 4040258 T C 20 4040763 T C 20 4040828 T C 20 4040923 T G 20 4040961 C G 20 4155648 C T 20 4155668 C T 20 4776659 G A 20 5889649 T C 20 6922046 T A 20 8475010 A G 20 9318946 A G 20 9353445 C T 20 9365303 T C 20 9371499 G A 20 9374613 G T 20 9440715 C G 20 9448947 G A 20 9449000 T G 20 9457170 C T 20 9459927 A G 20 10882821 C T 20 11821257 G A 20 12626712 G T 20 12626745 A G 20 14706879 T A 20 15313903 T A 20 15314383 G A 20 16239362 C T 20 16239376 C T 20 16239426 C T 20 18190882 C T 20 18191172 T C 20 18191291 G T 20 18466346 G A 20 20336724 C T 20 20336950 G T 20 20337707 A G 20 20337722 A G 20 20337869 G T 20 20338243 A G 20 20338247 T A 20 20338251 A G 20 20338825 A G 20 20338971 C G 20 20817609 G C 20 21142523 C G 20 21885619 A C 20 22297047 A G 20 22563571 G A 20 22892171 G T 20 23456589 T G 20 23456962 A T 20 23456975 C G 20 23457003 C G 20 23757966 G C 20 23758038 C A 20 23840240 T C 20 23840242 T C 20 23975455 C T 20 24649705 C T 20 24650360 G A 20 25845523 C T 20 25845579 C A 20 25845591 C A 20 25845594 G T 20 25943298 G A 20 26073480 T C 20 29517367 G A 20 29517535 C T 20 29520369 G A 20 29520383 A G 20 29551711 G T 20 31015643 T C 20 31019725 T C 20 31938046 C T 20 33581689 T C 20 33582279 C A 20 34101631 C A 20 34854605 T C 20 36012348 C A 20 36022154 T C 20 36030592 G T 20 36030622 T C 20 36838422 T C 20 37900688 C G 20 37900691 C T 20 39690342 T C 20 39710038 T G 20 41426178 C T 20 41677471 G C 20 42196825 T C 20 42733847 A G 20 43334843 G A 20 43962124 C T 20 43964620 C T 20 45659653 A G 20 46456298 C T 20 46456399 C A 20 46749867 G A 20 47128176 G A 20 47201278 C G 20 47201306 C T 20 47833636 T C 20 47833697 T C 20 48574438 G A 20 48574454 G A 20 50477441 C T 20 50677624 T A 20 50677714 G T 20 53503158 C T 20 53503198 C A 20 54066409 G A 20 54961073 A G 20 55462729 T C 20 55462744 G A 20 55463137 C T 20 55991479 G A 20 56169863 C A 20 56994740 A G 20 57479133 A G 20 57483948 G A 20 58057058 C A 20 58057077 T G 20 58057118 C A 20 58057119 T A 20 59495071 G A 20 59848508 G A 20 59848515 G T 20 59848519 A G 20 59848582 T C 20 59848585 A G 20 60495224 G A 20 60495285 G A 21 9483659 T C 21 9910262 A C 21 9954440 C A 21 9954672 C A 21 9954692 C G 21 9954700 T A 21 9954700 T C 21 9954718 C G 21 9954726 T C 21 9954750 C A 21 9954822 C T 21 9954874 G T 21 9954972 T G 21 9954978 G T 21 9954994 G A 21 10029331 A T 21 14457818 G A 21 14513159 G A 21 14524601 A T 21 14900799 C T 21 14900897 A G 21 14900901 T C 21 14936098 T G 21 15090065 G A 21 15090071 T C 21 15090282 T G 21 15090308 A G 21 15090315 G A 21 15090335 C T 21 15090336 G A 21 15090391 A G 21 15216110 T C 21 15216154 G A 21 15216190 T A 21 15219309 G A 21 15219323 T C 21 15373568 G A 21 15475013 C T 21 15475149 C G 21 15475439 G A 21 15475515 T C 21 16599891 C G 21 16599895 T C 21 16600408 G A 21 18236198 T A 21 19322853 T A 21 19322854 T C 21 19799542 C T 21 20144540 G C 21 20230102 C T 21 20230168 G A 21 20230169 T C 21 20230217 A C 21 20230294 C A 21 20230372 T C 21 20230390 G A 21 21201593 G T 21 21201603 A G 21 21561669 C G 21 21561683 A G 21 21562354 A T 21 22519731 A T 21 23687317 A G 21 24465037 A T 21 24563993 G T 21 25330218 A G 21 26832609 G T 21 26833183 C T 21 26833198 G A 21 28389497 A C 21 30115032 C T 21 30115170 T G 21 30115571 C T 21 30115579 T A 21 30115629 C G 21 30115651 A G 21 30115655 G T 21 30506189 A G 21 32114077 A T 21 32965156 T G 21 33471163 C T 21 33805478 A G 21 33805831 T C 21 34361496 G A 21 34776152 T G 21 34787638 C A 21 34793588 A G 21 34798982 G A 21 35602677 T C 21 36232156 C A 21 36252595 G A 21 36252622 T C 21 36253194 T A 21 36261705 G A 21 36357463 C T 21 36358229 G A 21 36420874 C T 21 36508295 A C 21 36972392 A G 21 41506058 A G 21 41506612 C T 21 42861181 G C 21 43528820 A G 21 43528822 C T 21 43528949 C T 21 43528970 C A 21 43528991 T C 21 43529061 T G 21 43529064 C T 21 43529078 A G 21 43529162 C T 21 43529185 C A 21 43529216 G C 21 43529224 A G 21 43529228 C A 21 45615963 T G 21 45616049 G A 21 46338651 C T 21 46339140 C T 21 47419697 C T 21 47419747 A G 21 47419770 G A 21 47419780 G A 21 47419794 T C 21 47419804 C T 21 47419817 A G 21 47419832 G A 21 47419835 A G 21 47419856 G A 21 47419859 G A 21 47419859 G C 21 47419860 T C 21 47419872 G A 21 47419875 A G 21 47419876 G A 21 47420016 G A 21 48021967 A T 22 16366289 C T 22 16366304 G A 22 16866125 G T 22 16867451 T C 22 16867494 T C 22 16867535 C T 22 16867555 G A 22 16867625 G A 22 16867671 T G 22 16867807 G C 22 17000863 G A 22 17001006 G A 22 17001044 G A 22 17001074 T C 22 17001080 C T 22 17001124 A G 22 17001134 C T 22 17001218 G C 22 17023726 T C 22 17349297 C G 22 17391914 A G 22 17513526 A C 22 17514026 G A 22 17514060 C T 22 18465978 C T 22 18845285 A T 22 18845397 T C 22 18863659 C T 22 19486391 C T 22 19621254 A G 22 20361753 C T 22 20361768 A C 22 21050028 A G 22 21050319 G A 22 21051859 G A 22 21051983 C A 22 21051987 T C 22 21051994 C A 22 21052014 A G 22 21052189 A G 22 21052193 T C 22 21052265 G C 22 21052303 C T 22 21287911 A G 22 21303690 G T 22 21303711 G A 22 21304408 A G 22 21304463 T C 22 21339915 T G 22 21342169 G C 22 21342811 C T 22 21343391 G C 22 21344287 C T 22 21344316 C T 22 21347410 G T 22 21347505 C T 22 21349548 A G 22 21349579 C T 22 21349676 T A 22 21349677 C T 22 21351819 G A 22 21470373 C T 22 21644653 G A 22 21644684 T A 22 21644783 C T 22 21647786 T C 22 21648685 G C 22 22401267 G A 22 22612065 C T 22 22625680 A C 22 22978886 T C 22 22978887 G A 22 22978887 G T 22 22980711 C G 22 23240831 T C 22 23246298 C A 22 23246323 C T 22 23657735 G A 22 23659783 C G 22 23659864 C T 22 24129129 G T 22 24134394 T C 22 24136214 T C 22 24136252 C T 22 24145923 G A 22 24158697 G C 22 24158709 A G 22 24159437 G T 22 24159452 A G 22 24167166 G A 22 24167185 C T 22 24167906 T C 22 24376322 G A 22 24377034 A G 22 24383954 C T 22 24654050 T C 22 24655566 A G 22 24659077 A G 22 24659078 T C 22 25043518 C T 22 25068063 C T 22 25068076 C T 22 25798856 G A 22 25799013 T C 22 25799024 T A 22 25832242 A G 22 26179312 C T 22 27863300 G A 22 28007568 G A 22 29090363 G A 22 29090890 G A 22 29099754 T C 22 29108112 A C 22 29108229 A G 22 29129741 T C 22 29999742 C G 22 29999784 C A 22 29999878 G C 22 30032484 A C 22 30053963 A G 22 30053984 A G 22 30054024 G A 22 30056945 G A 22 30064117 C T 22 30064731 A G 22 31071644 A C 22 32813600 T C 22 32813975 C G 22 33171838 G T 22 34225927 C A 22 34226068 G A 22 34226412 C G 22 34226440 T C 22 34842414 G C 22 35843103 C T 22 35843109 C T 22 36678453 C G 22 36678476 C A 22 36679058 T C 22 38054038 A G 22 41514151 C T 22 41514155 G A 22 41536064 T C 22 41543721 G A 22 41544167 C T 22 41552926 T G 22 41554690 C T 22 41565285 A G 22 41565827 A G 22 41566823 A G 22 41570071 T C 22 42232577 C T 22 42232588 G A 22 42522312 T C 22 42522392 G A 22 42523003 A G 22 42523209 T C 22 42523211 T C 22 42526049 C G 22 42536064 T C 22 42536954 A G 22 42537023 T C 22 42537029 C T 22 42537115 C T 22 42537119 C T 22 42537127 A G 22 42537196 T C 22 42538399 C T 22 42539105 T C 22 42539720 C G 22 42540667 C T 22 42540668 A G 22 42547739 G A 22 42547755 C G 22 42548094 A G 22 42548880 G A 22 43735824 T C 22 44510034 T A 22 44510219 T C 22 44510230 T C 22 44510240 A G 22 44510329 C T 22 44510554 G A 22 44510624 A G 22 44510631 G T 22 44511408 G C 22 44511478 T C 22 44511626 T C 22 44511663 G C 22 45676445 C G 22 47002427 T C 22 47566744 G A 22 48301616 T C 22 48301642 C T 22 48301646 G A 22 48301660 C T 22 49258340 G C 22 49258341 G C 22 49258485 A G 22 49258525 A G 22 49258700 G C 22 49258701 G C 22 49551354 A G 22 49551680 G A 22 49551682 G A 22 49551684 A G 22 49551689 C A 22 49551690 C T 22 49551694 G A 22 49551724 G C 22 49551734 T C 22 49551749 G A 22 49551895 G A 22 49551927 G A 22 49551969 C T 22 49551990 T C 22 50017556 G A 22 51115526 T C 22 51115575 C T X 323851 G A X 323960 C T X 324085 G A X 324097 T C X 324135 G A X 324137 A C X 324137 A G X 324146 G A X 324224 C G X 324245 G A X 933046 T A X 933079 A T X 933848 C T X 1414936 C A X 1415582 A C X 1415726 G C X 1415754 A G X 1416082 A C X 1416494 A C X 1416825 A G X 1416859 C G X 1417722 A G X 1882476 C A X 1882644 G C X 1882671 T G X 1883661 T G X 2320736 C T X 2320768 C T X 2550218 A G X 2550271 T C X 3354064 T C X 3354073 C G X 3354304 T G X 3354320 C G X 3354323 T C X 3354489 C T X 3947844 G A X 3947940 G A X 3948055 A G X 3948056 C A X 3948072 C A X 3948325 A G X 5728321 G A X 5728524 T A X 6750277 G A X 6750665 T C X 7811259 G C X 7811504 G A X 7811645 C G X 7811747 T C X 7812017 C T X 7812081 C T X 7812197 T C X 8138080 G C X 8138160 T C X 8138165 C G X 8138170 C G X 8138171 T C X 8138182 A G X 8434256 A G X 8434367 C T X 8434432 A G X 8434433 G C X 8960281 C T X 9372403 A G X 9374934 C A X 9375163 A C X 9376287 T G X 9377057 G A X 9378063 T C X 9378595 C G X 9380687 C G X 9382151 T C X 9909935 T C X 9910404 A T X 9910483 C A X 11985475 C T X 11985898 A T X 12023301 C G X 12023305 A G X 12023314 A G X 12023535 G C X 13222032 G A X 13668792 C T X 13669007 G A X 14291097 G A X 14291174 G A X 14291313 T C X 14852765 G C X 15665327 C T X 16351394 T C X 16351704 C T X 16351825 A G X 17387641 A G X 17794293 A G X 17794390 G C X 18247605 T C X 21942691 C T X 22313514 G A X 22314058 G C X 22553123 A G X 22553314 G A X 24007345 T C X 26225293 C T X 26225571 C A X 26735568 A G X 26735679 G T X 27029285 C A X 28676918 A G X 28871324 A G X 28871343 A G X 28871801 C T X 29149454 G T X 29149490 A G X 30277764 C T X 30618867 T C X 31277151 C T X 32224435 T C X 32889854 G A X 33050164 T C X 34444321 T G X 35083559 C A X 35971670 A C X 35971684 A G X 36959988 C T X 39944288 C T X 40857040 C T X 41546554 C T X 43440829 T C X 43440856 T C X 44601065 T G X 45028722 T C X 45029140 A G X 45634577 C A X 47966001 A G X 48134195 T C X 48134267 C A X 48134283 A G X 48134352 G A X 48134363 T C X 48196483 C T X 48548091 C T X 49337861 G A X 49337915 G A X 50776337 A C X 51361920 C T X 54846603 C T X 54976385 T C X 55684550 G C X 55684552 A T X 55684553 T C X 57163476 C G X 62573853 A G X 67310673 G A X 67965273 C T X 70338399 A G X 70354080 C A X 70355942 G C X 70361608 T C X 70361619 T C X 70886761 G A X 70939147 G C X 72066630 C T X 74375460 C T X 74803555 T A X 75449353 G C X 75449473 A G X 75555810 C T X 76845060 C T X 76848940 C T X 76912391 T C X 76919991 T C X 77671395 A G X 78526387 C G X 79376181 C G X 79376359 G A X 79712450 C A X 81978259 A G X 82987871 T A X 82988286 T A X 83489042 C A X 84535451 A G X 85996514 A G X 86125877 C T X 86126034 A C X 86126184 C A X 86126214 C A X 88458887 G A X 88459088 A G X 88460086 C T X 88460163 C A X 88460234 C T X 88460693 C G X 88461023 A C X 88461098 G T X 88461193 G C X 88461257 T C X 88461306 C T X 88461381 G A X 88461454 G T X 88461489 G A X 89179384 G A X 89531825 G A X 90467751 C T X 90468268 A G X 90937645 C T X 90937839 C T X 91240753 G A X 91241043 C T X 91651454 G A X 91651560 T C X 91651589 T C X 91651601 C G X 94235658 G C X 97861548 G A X 97861806 C G X 100600966 C T X 100604681 C T X 100611432 G A X 100614597 C T X 100615025 G T X 100616989 C T X 100625293 C T X 100626864 C T X 100630500 G A X 101383199 T C X 102633394 A T X 105034364 C G X 106516125 G C X 107492960 G C X 108115548 C T X 111815818 T C X 114629506 T C X 114997566 A G X 115005861 T C X 115005934 C T X 115959641 C A X 116167250 G A X 117479815 C G X 119313694 G C X 122008986 A G X 122648454 T C X 122696563 C T X 122932585 A C X 123159474 T C X 123181551 G A X 123194867 T C X 123197557 T C X 123227604 T C X 124576157 G T X 125779449 T C X 125779655 C T X 126247979 C A X 127724972 C T X 128495450 C G X 130974130 T C X 130974165 A G X 130974206 G A X 130974276 A C X 130974277 A C X 130974284 G C X 130974290 C G X 130974310 T C X 130974312 G A X 132426862 G C X 135961796 C G X 137367771 T C X 138265862 A T X 138266294 T C X 139298295 C T X 139298601 C T X 139298612 T C X 139960824 T C X 140147409 A G X 140147500 C T X 140336615 T A X 140673061 C T X 140673198 T G X 140673372 C T X 140673423 G C X 140786796 G A X 140993642 C T X 140993905 C T X 140993912 C T X 140993913 C G X 140993945 T C X 140993947 T C X 140993989 T C X 140994031 G C X 140994037 C A X 142605437 A C X 142605455 C T X 142605483 A G X 142605491 G C X 142605583 C T X 142605628 G A X 142804302 T C X 142804326 C T X 143901920 T C X 143902298 G T X 144328894 C T X 144940393 G A X 146052064 T C X 146052294 G C X 146266206 T G X 146266521 G T X 146679744 A G X 146679975 T A X 146680129 C T X 149382872 C G X 149383074 A G X 150162380 C T X 152155921 C T X 152156110 C T X 152156144 A G X 152156176 G C X 152538286 A T X 152538627 G A X 152582526 G A X 153009797 G A X 153010224 C T X 153010267 G A X 154376753 C G X 155233098 T C 

What is claimed is:
 1. Use of a reagent for detecting a marker in the preparation of a reagent for evaluating homologous recombination deficiency (HRD), the marker is composed of the SNP sites in which the site information is shown as follows: Chromo- Refer- Varia- Chromo- Refer- Varia- Chromo- Refer- Varia- some Location ence tion some Location ence tion some Location ence tion 1 105279 G C 1 251663 C G 1 649113 C T 1 649192 A T 1 743072 C A 1 924528 C A 1 1127507 G A 1 1127523 C T 1 1128429 G A 1 1128521 C T 1 1650410 T C 1 2488930 G A 1 2631804 G A 1 2693121 A T 1 3097439 C T 1 3097459 C T 1 3097464 A G 1 3097498 A T 1 3097509 C T 1 3097522 T C 1 3097532 T G 1 3097534 G A 1 3098219 C A 1 3098360 A G 1 3098386 G T 1 4196428 G A 1 4967739 G C 1 4967744 C A 1 5393906 G A 1 5876714 T A 1 5876956 A G 1 5876977 C A 1 5876988 A G 1 5877088 C G 1 5877112 C T 1 5877121 C A 1 5877138 G A 1 5877145 C A 1 5877169 C A 1 5877171 T C 1 5877327 A C 1 5877329 A G 1 5877337 G A 1 5877367 G A 1 5877384 C T 1 6481623 G A 1 9493601 C T 1 9494062 A G 1 9494142 T C 1 10357406 A G 1 11167760 C T 1 11167829 C T 1 11168529 A G 1 11174067 A T 1 11175176 T C 1 11181630 G A 1 11189191 G A 1 11193401 A C 1 11193406 C T 1 11193408 C T 1 11209899 T C 1 11227224 C T 1 11269796 T C 1 11292753 A G 1 11293200 C T 1 11293216 A G 1 11293792 A C 1 11303610 T C 1 11307412 G C 1 11315853 G A 1 11318763 C G 1 11318983 T C 1 12188028 C A 1 12854713 G T 1 12854716 A G 1 12886052 C T 1 12886098 T C 1 12886436 C A 1 12920067 C G 1 12920132 A G 1 12920191 T C 1 12920200 G A 1 12920622 C T 1 12920708 C A 1 12940618 A G 1 12940822 A T 1 12941059 C A 1 12941086 C A 1 13143375 G T 1 13143405 A G 1 13143441 C T 1 13143453 C T 1 13367310 C G 1 13367310 C T 1 14228227 C G 1 14228236 A G 1 14228340 G C 1 14228356 T C 1 15829457 C G 1 16451413 C T 1 16460541 T C 1 17345113 G C 1 17348847 G C 1 17350243 T C 1 17353988 T G 1 17370970 C T 1 17687161 G C 1 18476868 T C 1 18476876 A G 1 18477394 A C 1 18477450 G A 1 20058523 A G 1 20915418 C G 1 20916080 C G 1 20931774 A G 1 20944721 G A 1 22234424 G C 1 22301165 C T 1 22301180 G A 1 22301199 C T 1 22301755 A G 1 22301769 G A 1 22301770 C T 1 22301824 T C 1 22326109 T C 1 22326455 T C 1 22326488 T C 1 22326548 A G 1 22326587 G A 1 23909324 T A 1 24192453 T C 1 26228409 A G 1 28439964 C T 1 28563391 C T 1 29232578 C G 1 31581492 C T 1 31857847 G A 1 31857869 G A 1 31857916 C T 1 33819830 A C 1 34989237 G A 1 37049763 C T 1 37568312 C G 1 38010651 G A 1 38010751 C T 1 39944488 T G 1 40367607 G C 1 40367625 G T 1 40799427 G A 1 41940980 C T 1 42042317 C T 1 42042915 C T 1 43803222 G A 1 44606254 C T 1 44606565 A G 1 45880669 C T 1 45880751 C T 1 46727304 C T 1 46737961 C T 1 47009757 G A 1 47009799 A G 1 47009829 G T 1 47541531 C A 1 48119989 C T 1 48120087 T C 1 50591705 C G 1 50591743 C T 1 53116251 A G 1 55390669 T C 1 55834642 G A 1 55835253 G A 1 57548321 C G 1 59621601 C T 1 59621636 A T 1 59622219 G A 1 59622225 T G 1 61465647 C G 1 62148611 A G 1 63521709 T C 1 63521755 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201489565 C T 1 201978049 C T 1 201978068 G A 1 202096562 T C 1 203274536 C A 1 203842900 C T 1 203843484 T C 1 204315839 T G 1 204494436 C T 1 204495253 G A 1 204500257 G A 1 204511704 T C 1 204513402 G A 1 205816893 T C 1 205816923 G A 1 206646274 G T 1 206646311 C T 1 206647387 T G 1 206647450 A G 1 206669136 C A 1 207807908 C T 1 207807921 G C 1 207807928 G A 1 207808385 C G 1 208164511 C T 1 208780934 A C 1 210371949 A G 1 210372455 T C 1 210827321 T C 1 210827322 G A 1 210827379 C T 1 211126407 G A 1 211855564 G A 1 211855593 T A 1 212224761 A G 1 212224946 G T 1 212240533 A G 1 212245792 A G 1 214386346 T G 1 214386351 C T 1 214386365 A T 1 214571527 C G 1 215128241 C T 1 216840332 G C 1 216840371 C T 1 216840798 C T 1 218238495 T C 1 218572004 G A 1 219969405 T C 1 222477115 C A 1 222642478 C A 1 222642700 G A 1 222677791 C G 1 223089124 G A 1 223718462 G A 1 223718518 C A 1 224164610 G A 1 224220492 A G 1 224220734 G A 1 224644312 C T 1 226549498 G A 1 226553934 A C 1 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246362962 T C 1 246363094 G C 1 246641904 T C 1 246642046 A G 1 246642078 T C 1 246642155 A G 1 247337911 A C 1 247338427 A G 1 247591141 G A 1 248084854 A G 1 248084909 T G 1 248085341 T A 1 248436611 G A 1 248436616 A G 1 248907914 G T 1 248907917 C T 1 248907919 C T 2 197601 A G 2 197712 T C 2 1366783 G A 2 1366859 G A 2 1833356 T C 2 1833781 G A 2 2413270 T G 2 2413783 C T 2 2940325 G A 2 2940329 A G 2 3332735 A G 2 3333243 T G 2 3877140 C T 2 3877747 G A 2 4561867 T C 2 5389739 A G 2 5768841 C G 2 6426700 T C 2 6426703 C T 2 6943743 C A 2 7068710 C G 2 7999597 G A 2 9446167 C A 2 9446205 G A 2 10381717 C T 2 10676227 C G 2 10676309 C T 2 10676315 A G 2 10676317 T G 2 10676320 G A 2 10676368 T C 2 10676498 T C 2 10676610 G A 2 11093401 T C 2 11093430 T C 2 11242610 C T 2 11994573 A C 2 11994575 G A 2 11994645 A G 2 11994813 A G 2 11994822 C G 2 11994829 T A 2 11994840 T A 2 11994849 T C 2 11994863 A C 2 11994865 G A 2 11994907 T C 2 13981557 C T 2 14082251 G T 2 15832606 G A 2 16086469 C T 2 19524172 T G 2 21634473 T C 2 24167417 T G 2 24439048 A G 2 25458379 G A 2 25472784 C T 2 25505793 T C 2 25522795 G A 2 26367863 T C 2 26835397 C A 2 26835419 G A 2 27615389 C T 2 28350922 G A 2 29416946 T C 2 29432982 C T 2 29436633 G T 2 29437182 T C 2 29451511 C G 2 29940820 C T 2 30142547 G C 2 31552688 G C 2 31553158 C G 2 33896721 G A 2 35130065 T G 2 36768719 C G 2 37050374 A G 2 37996061 C T 2 38002857 T G 2 40783500 C G 2 40783501 T C 2 41273446 A C 2 41273450 T C 2 43779665 T C 2 43783241 C A 2 43783273 G A 2 43787758 G C 2 43798616 C G 2 43802347 T A 2 43802380 C G 2 43803897 A C 2 44274227 G C 2 44274729 A G 2 44292977 C T 2 44985166 C G 2 45576533 C A 2 45577081 A G 2 46064330 A G 2 46525391 G C 2 46588488 G T 2 46597296 T C 2 46603260 C T 2 46603438 A G 2 46604857 T C 2 46605659 A G 2 46611471 G A 2 47597029 C A 2 47602241 T C 2 47606683 T C 2 47612156 A G 2 47639871 T G 2 47643191 C G 2 47672475 T A 2 47698384 G A 2 47703241 A G 2 47703984 T G 2 47709704 T C 2 48022900 A G 2 48914615 C G 2 48941428 C T 2 48952574 C T 2 48956475 C T 2 48956512 A G 2 48958595 A G 2 48958626 A G 2 48958647 C T 2 48982358 G A 2 49070593 G C 2 49071094 G C 2 49660621 A T 2 50231869 G A 2 50232465 C T 2 50763570 A G 2 51450722 A G 2 52153976 T C 2 53792407 T C 2 55066617 G C 2 56338148 G T 2 58453585 T C 2 58453620 C G 2 59260307 G A 2 61183901 A G 2 62373915 T C 2 64720254 G A 2 64892858 G T 2 65863984 T G 2 65864061 C G 2 66063089 A G 2 66955742 C T 2 68999640 G A 2 71256898 G T 2 71256905 C A 2 71256965 G A 2 71283017 G T 2 71283128 G A 2 71283247 G A 2 71283425 T G 2 73295583 G A 2 73869120 G A 2 73869558 T C 2 75089569 A G 2 75090155 G A 2 76124531 C T 2 76124535 C T 2 76890353 T A 2 77637227 A T 2 79445642 A T 2 80101025 G A 2 80101040 A G 2 81423752 T C 2 83419234 G C 2 84073752 A T 2 84074312 A G 2 85141323 A G 2 85685734 A G 2 87405001 T C 2 87405397 G A 2 87444116 A G 2 87444177 A G 2 87444438 C T 2 87615504 A G 2 88433305 T C 2 88739133 T A 2 88739134 C G 2 88739141 C A 2 88739644 C G 2 89080379 C T 2 89080394 C A 2 89080854 C G 2 90447633 T C 2 90448948 A G 2 90448956 C T 2 90449010 G T 2 91671081 C T 2 91671100 T C 2 91671122 C G 2 91715572 T C 2 92151397 G A 2 95849653 T C 2 96596710 G C 2 96809331 T C 2 96920993 C T 2 97366088 T C 2 97366599 A G 2 98223750 A G 2 99537295 A C 2 101350715 G A 2 102254291 T G 2 102254307 G A 2 102254364 C G 2 102616745 G T 2 102617204 T C 2 104432433 T C 2 104432494 A C 2 104599371 T G 2 105671951 C T 2 105672240 T G 2 106543154 A T 2 107019359 T C 2 107019383 G T 2 107019457 T C 2 107019874 T C 2 107424428 C T 2 108481932 C G 2 109928180 C T 2 109928207 G T 2 110800798 C A 2 110800846 G A 2 112289514 C A 2 112289579 T C 2 112506112 C T 2 112506288 T C 2 112544651 G A 2 113691060 T C 2 113691288 T C 2 113869803 C T 2 113869843 C A 2 114256098 G A 2 114256343 A G 2 114259673 C A 2 114288352 G T 2 119480974 C T 2 120130317 C T 2 120130337 C T 2 120130347 G T 2 121321830 C T 2 122995587 G T 2 122996267 C T 2 123153811 A G 2 123154175 A G 2 123921841 C A 2 124206212 G T 2 124206727 G C 2 124206743 G A 2 125189819 A T 2 127420931 A G 2 127811810 C T 2 127812457 G A 2 127812468 A G 2 128018522 T C 2 129473008 C T 2 130126515 A G 2 130801047 T C 2 130805820 T C 2 131233331 C T 2 131945811 C A 2 131947586 C T 2 131955247 G C 2 132045098 C G 2 132046355 C T 2 132107348 A C 2 132181110 C T 2 132533478 T C 2 132534075 G T 2 132579856 G A 2 132579930 A G 2 132580131 A C 2 132796086 G A 2 132796335 A G 2 132796339 A G 2 132797478 G A 2 132809855 A G 2 132809875 G A 2 132809905 G T 2 132872466 C A 2 132872691 A G 2 132872847 G T 2 132905500 C T 2 132905513 C A 2 132905976 G A 2 133644992 T A 2 133645369 G A 2 133645476 G A 2 134945535 A G 2 134946060 T C 2 137181641 C A 2 137181641 C G 2 137181661 C T 2 137900678 A C 2 140000027 A G 2 140991087 A C 2 140992063 G C 2 141028164 C T 2 141055080 T G 2 141072930 C T 2 141114235 C G 2 141128001 C G 2 141129072 T C 2 141136007 T C 2 141202412 C T 2 141202499 T A 2 141245486 G A 2 141271959 T G 2 141272545 G A 2 141283130 T C 2 141284090 C G 2 141293912 G T 2 141299730 T C 2 141299775 C T 2 141355954 C T 2 141457603 G C 2 141460317 T A 2 141526501 T C 2 141570937 G T 2 141571590 C T 2 141624902 T C 2 141641859 C A 2 141644076 T A 2 141660215 T C 2 141661007 A G 2 141707558 T C 2 141707610 A G 2 141777212 C G 2 141812434 C T 2 141819422 G A 2 142004512 A C 2 142238325 A T 2 143225895 G A 2 143226379 A G 2 143226439 G T 2 143748793 A G 2 144559694 G T 2 147187335 T C 2 148300099 G A 2 148300132 G A 2 149284724 G A 2 150920975 T C 2 152025225 A G 2 152943265 T C 2 154500721 T A 2 155316251 T C 2 155316904 C T 2 156332987 G C 2 157262577 T G 2 160895559 T C 2 160895602 C G 2 161487015 T A 2 161822563 G A 2 162101078 A G 2 166025675 A G 2 167857455 G C 2 170143494 A C 2 170624543 A G 2 171678379 C T 2 172034684 A G 2 172035195 G T 2 173664873 T C 2 174482931 G A 2 175584721 G C 2 176675940 A G 2 177107092 G C 2 178098502 G T 2 178494520 A G 2 178528351 T C 2 178528360 A G 2 178528874 T C 2 178545736 T C 2 178576681 G A 2 178681294 T C 2 178682329 T A 2 178682901 C T 2 178684720 G C 2 178704709 A G 2 178740334 T G 2 178740393 C T 2 178740398 C G 2 178969434 G C 2 179296821 G A 2 179729081 C T 2 180308028 C T 2 180734989 A C 2 181490053 C T 2 181490633 G C 2 182433865 G A 2 182433873 G T 2 182434468 G A 2 182434507 A G 2 183726713 C T 2 184128825 A G 2 184912216 T C 2 184912648 T C 2 187169224 G A 2 187866471 C T 2 187867057 G A 2 190176234 G T 2 190176235 C A 2 190708982 C A 2 190741733 G A 2 190742374 A G 2 192422875 G T 2 193726153 C T 2 193726212 T C 2 193726268 A G 2 194468850 T C 2 195079687 G C 2 196335442 T G 2 197037730 G A 2 198273591 C T 2 198274929 G A 2 198285554 C G 2 198905073 T A 2 201487990 C T 2 212252955 C T 2 212292929 G C 2 212530466 C T 2 212543510 T C 2 212544193 T C 2 212566477 G A 2 212569828 C T 2 213296501 T G 2 214019110 T C 2 215595440 T A 2 215595445 C A 2 215610777 T C 2 215617500 T C 2 215631987 A G 2 215632629 G T 2 215645030 T C 2 215645046 C T 2 215672347 C T 2 215672827 C T 2 215672833 A G 2 216203296 A G 2 216860550 A T 2 217021055 A G 2 217453875 T C 2 217453939 C A 2 220136059 C A 2 220634227 C A 2 220634291 A G 2 222231318 G A 2 222231319 A G 2 222231322 C T 2 222231334 A G 2 222232311 A G 2 222233697 T C 2 222721065 C T 2 223900314 C T 2 224277502 T C 2 225346377 A G 2 225347043 T A 2 225360975 T C 2 225360980 T C 2 225360985 T C 2 225362798 A G 2 225367995 C T 2 225367996 C G 2 225368094 G T 2 225371246 A C 2 225434256 C G 2 225658104 G A 2 228264500 C T 2 228725134 C T 2 229039040 C T 2 230470702 A G 2 230471160 T G 2 233311776 G T 2 233311824 A T 2 234071665 A C 2 234676118 A G 2 234680679 A C 2 234681416 T C 2 235386951 T C 2 236618069 T C 2 236618494 A T 2 236618499 A G 2 237032523 A G 2 237032837 G A 2 237820187 C T 2 238512001 G A 2 239675968 C T 2 239675977 T G 2 240872090 G A 2 241063584 G A 2 241588811 T A 2 242793849 G A 2 243009529 A G 2 243059290 A T 2 243059293 C A 2 243071262 G T 2 243088710 G C 3 142069 A C 3 1947348 A G 3 1947477 T C 3 2409278 A G 3 2409817 T C 3 3142901 T C 3 3142943 T C 3 4025464 A G 3 4025573 T C 3 4665123 A G 3 5131185 C G 3 7888983 T C 3 8730717 G A 3 8730781 A C 3 9877716 G A 3 9877783 G A 3 10030236 T C 3 10030521 T C 3 10034925 G C 3 10035601 C T 3 10075983 T C 3 10075991 A G 3 10078247 A G 3 10078289 G C 3 10080722 T C 3 10083169 C T 3 10085816 G T 3 10094418 T C 3 10102377 T A 3 10104186 A T 3 10106924 G A 3 10108745 G C 3 10119603 C A 3 10122575 T C 3 10131831 C T 3 10133710 G A 3 10134766 C T 3 10140115 G A 3 10183274 C T 3 10183337 G A 3 10191219 C G 3 10191943 G A 3 11041606 G A 3 11042207 T C 3 11767152 A G 3 11902162 G A 3 11911822 C A 3 11912512 A C 3 11912534 T C 3 11912557 G A 3 11912622 G A 3 11912635 C T 3 11913124 A G 3 11913188 A G 3 11915481 C T 3 11924678 C G 3 11925226 G A 3 11925254 T C 3 11926243 C G 3 11926269 G A 3 11926423 A G 3 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A 3 32072004 T C 3 32195427 T C 3 32232782 G T 3 32301422 C A 3 32301426 C T 3 33086893 T C 3 33841065 A G 3 36148273 C T 3 36148306 T G 3 36148330 C T 3 36148763 G C 3 37067050 A G 3 37627598 T C 3 37790112 C T 3 38737643 T C 3 40439614 G A 3 40440116 G A 3 40537215 C A 3 41269152 A T 3 45251978 G A 3 46511969 G A 3 47083782 C G 3 47103376 C T 3 47108330 C T 3 48486773 G C 3 48487338 G A 3 48487353 A C 3 51102839 G A 3 51755441 G A 3 52597664 G A 3 52621839 C T 3 52659124 T C 3 52678494 G A 3 53884074 G C 3 53999979 A G 3 55738985 T G 3 56235603 C A 3 56737197 C T 3 58036651 T C 3 58594418 C A 3 59701045 C T 3 60439446 T A 3 60545661 T A 3 61557787 G A 3 63442932 A T 3 63443008 A C 3 64184676 G A 3 65289882 C T 3 65734943 T C 3 66077019 T C 3 66077076 A T 3 66077167 G A 3 66077485 G A 3 66746914 T C 3 67145056 T C 3 69392244 G T 3 69392263 T C 3 69392331 C A 3 69392754 G A 3 69392762 G A 3 69392793 T C 3 70013349 A G 3 71847123 A G 3 72978434 T C 3 73433369 G A 3 74513397 A G 3 74514007 T C 3 75365484 T C 3 75366035 C T 3 75397290 A G 3 75475805 A G 3 75572090 T C 3 75572133 C G 3 75572165 G C 3 75572199 C T 3 75572202 T C 3 75572238 G A 3 75572329 G C 3 75572368 A C 3 75572374 G C 3 75875639 A C 3 75875740 G A 3 75875973 G A 3 75876015 T G 3 75876023 A G 3 75876115 G A 3 76779549 C G 3 76779577 T G 3 76780491 A G 3 77338588 A C 3 77338630 G T 3 77338634 T C 3 77338635 A C 3 77338636 A C 3 77338640 T C 3 77338835 G C 3 77338920 T C 3 77339156 G C 3 77339675 T G 3 77340008 T C 3 77345372 T G 3 77345549 G A 3 77345598 G A 3 77459994 T C 3 80457094 G A 3 81833577 T C 3 81833966 G A 3 81834060 G A 3 81834065 T A 3 83497272 A G 3 84924659 T C 3 85870199 A T 3 86702627 G T 3 87386674 T C 3 87695509 C T 3 89176645 A G 3 89444743 G T 3 89448936 T A 3 89498096 C A 3 89521965 T G 3 89528313 T G 3 93903910 G A 3 95886072 A G 3 97940846 C T 3 97957539 C T 3 97957580 G C 3 97957609 C T 3 97957611 G A 3 97983257 C G 3 97983265 C A 3 97983711 T C 3 98840224 C T 3 101620615 G A 3 101620682 A G 3 102650845 G C 3 103705800 A T 3 104106527 G A 3 104106528 G A 3 104106562 C T 3 104639822 T C 3 105377515 C T 3 105400846 A G 3 105420602 C T 3 105422536 T C 3 105439311 T A 3 105452593 A G 3 105459717 A G 3 105571964 C T 3 105586714 T C 3 107805553 C G 3 108034167 A C 3 109128553 G T 3 109128692 C T 3 109775371 G A 3 109775869 G A 3 110496808 T C 3 112243112 A C 3 112352718 A G 3 112933625 A G 3 112933635 T C 3 117156240 G A 3 117156255 C T 3 117156294 C A 3 117156738 T C 3 119272235 T C 3 119419376 G A 3 120402581 G T 3 122380722 C A 3 123957278 C T 3 123957294 C G 3 124410346 A G 3 124840312 T A 3 125431505 A C 3 125431673 A T 3 125453782 G T 3 125453797 C T 3 125453908 G T 3 125453977 A T 3 125454162 C G 3 125454180 A C 3 125482012 T G 3 125482430 C T 3 125484006 G C 3 125484009 C T 3 125494802 T C 3 125494864 T C 3 125495356 A G 3 125495487 T C 3 125495558 A G 3 125639885 C A 3 125639911 C T 3 125643329 G A 3 125643332 A G 3 125643719 A G 3 125643772 G A 3 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184220878 G C 3 184220879 G A 3 184220880 T C 3 184220890 T C 3 184220894 T C 3 184220902 A C 3 184220907 A T 3 184220910 T C 3 184220915 A G 3 184220920 T C 3 184220924 C T 3 184220940 C T 3 184220945 G A 3 184220948 T A 3 184220950 T C 3 184928239 T C 3 186508574 G C 3 188293043 T C 3 189382904 T C 3 189383430 C T 3 190093573 G C 3 190093689 G T 3 190093915 T C 3 190094003 T C 3 190094024 G A 3 191093053 T C 3 191093080 A G 3 191741924 C T 3 191742322 G A 3 194426037 C A 3 194712317 C A 3 194723092 G T 3 195384760 G C 3 195384844 T G 3 195399268 A C 3 195436937 A C 3 195437073 A G 3 195437584 G C 3 195437844 T G 3 195437869 C T 3 195437970 T C 3 195437979 T G 3 195437988 T C 3 195437989 C G 3 195437990 A C 3 195437994 A G 3 195438024 T G 3 195438126 T G 3 195438174 A G 3 195438443 T C 3 195438480 A C 3 195692049 G T 3 195692516 C T 3 195692570 G A 3 195700978 A C 3 195701115 A G 3 195709312 G C 3 195709355 C G 3 195717337 C G 3 195872302 C T 3 195872790 T G 3 196379737 C G 3 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3974559 T C 4 3974583 G C 4 4060689 G A 4 4061299 T C 4 4099959 G A 4 4112309 A G 4 4112604 A G 4 5189645 G A 4 5189717 A T 4 5652298 G C 4 6200768 C T 4 6881739 G C 4 6881785 G C 4 8999303 T A 4 8999512 C T 4 9001121 G A 4 9001176 G C 4 9001703 T C 4 9012383 A T 4 9052653 G C 4 9137789 G C 4 9137790 A G 4 9137990 G A 4 9158848 G A 4 9159079 T G 4 9159219 C T 4 9159256 C G 4 9163190 A T 4 9271895 T G 4 9531098 A G 4 9532659 G T 4 9584058 G A 4 9673458 T C 4 9673980 C T 4 9696823 G A 4 9700910 A T 4 9757407 G A 4 9757485 G A 4 10180622 T C 4 10180643 T C 4 10726609 G A 4 10726610 C T 4 10726707 C T 4 12056196 T C 4 13031210 T G 4 14232397 C T 4 14837656 C T 4 15117509 G A 4 15733093 C A 4 15733108 G T 4 15733159 A G 4 17348027 A G 4 17503839 G A 4 18056140 C T 4 18798633 C A 4 19250760 C T 4 21551721 T C 4 21552230 A G 4 23715644 C T 4 24142003 A C 4 25721273 C T 4 27128768 C T 4 27683108 T A 4 28247387 G A 4 28247910 G A 4 28551237 G A 4 29333030 C T 4 29333037 C T 4 29707479 G A 4 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T 4 55967806 A G 4 55971400 G A 4 55974290 C G 4 55985142 A G 4 55985149 A G 4 55985209 C G 4 55991731 T C 4 57917346 G T 4 58969178 C G 4 58969622 A C 4 59117179 C A 4 59685846 A G 4 63895205 T A 4 64379405 A G 4 64931039 T C 4 66270412 C T 4 66355888 T C 4 66355901 G T 4 67970457 T C 4 69901970 C T 4 70354884 G A 4 72347419 G T 4 73292973 C T 4 74322255 T C 4 74738851 G A 4 75394764 A G 4 75395312 G A 4 75395322 C A 4 78990229 C A 4 78990900 C A 4 79482186 G A 4 79602718 G A 4 80386263 T G 4 80801388 T A 4 84013033 C T 4 86340131 C G 4 86340164 G A 4 87264746 T A 4 87264750 G A 4 87692129 T G 4 87695876 T A 4 87718279 G A 4 87732483 C T 4 87791437 C T 4 89777379 C G 4 90228238 C T 4 93487149 A T 4 93487465 C A 4 95088301 T C 4 95606136 T C 4 99443068 A G 4 99443113 A G 4 99443127 T C 4 99443569 T C 4 99443585 G A 4 99443611 A T 4 100238998 T C 4 101572039 G A 4 102854264 C T 4 104452689 T A 4 106164284 T G 4 106193588 A G 4 106914301 C T 4 106914306 A T 4 106914338 C T 4 106914855 G A 4 108124872 G A 4 108125157 G A 4 108125170 C A 4 108565609 G A 4 111944989 A G 4 113180779 C T 4 113181343 T C 4 113486769 T C 4 115241715 C G 4 115987887 A T 4 116002140 T C 4 117957242 T G 4 118496905 A G 4 118496919 T C 4 118497508 C G 4 118503372 C T 4 119252323 C T 4 119252368 G A 4 119526740 C G 4 119527206 C T 4 119944319 A G 4 119944900 A G 4 119944903 C A 4 120133549 T G 4 120324707 T C 4 120325264 C T 4 120325273 T C 4 120355709 T C 4 120751902 T A 4 121089766 G C 4 121738049 T C 4 122290719 G A 4 122290979 G C 4 122291131 T G 4 122431338 T C 4 122683623 C T 4 124946414 C T 4 124946423 A G 4 125173747 C T 4 125725127 A G 4 127856273 T G 4 128518960 C T 4 132832700 T G 4 132832731 A G 4 133045796 A G 4 133824971 A G 4 133825066 G A 4 133825500 C T 4 133825533 A G 4 133885960 T G 4 134784133 G A 4 137489544 C A 4 137985807 C T 4 138698629 T A 4 139796813 G A 4 140619075 T C 4 143003526 A G 4 143034019 A T 4 143034029 G A 4 143044829 A G 4 143045482 G A 4 143066775 A G 4 143095131 C T 4 143095139 C T 4 143095201 C T 4 143114003 T C 4 143114011 A G 4 143114040 A C 4 143114482 T C 4 143114548 A G 4 143114556 A G 4 143114558 G A 4 143114598 G C 4 143129292 G A 4 143236139 T C 4 143236158 T C 4 143323915 T G 4 143326120 G T 4 143326714 T G 4 143352065 T C 4 143926811 A G 4 144754667 A G 4 145214743 G A 4 145568682 A C 4 146656399 T C 4 147206992 G A 4 147207075 G C 4 147208378 C G 4 147970517 G A 4 148024671 G C 4 149067352 C G 4 149870390 T C 4 150167697 A C 4 150674206 A T 4 151259617 T C 4 153254121 C T 4 153960301 T A 4 155298773 T G 4 155299346 T C 4 155851079 C A 4 156433308 G A 4 156607373 A G 4 157616767 G A 4 159194870 G A 4 159931005 G C 4 160823765 G C 4 161285415 G A 4 161956269 G A 4 161956317 C T 4 161956363 T A 4 161956376 C T 4 161956767 A G 4 161956781 A C 4 162129559 A G 4 163086385 A C 4 164465973 A T 4 164890625 T C 4 165933477 C A 4 167125325 C G 4 167654337 C T 4 167654397 C G 4 167654397 C T 4 167654427 C A 4 168292643 G A 4 168292723 A G 4 168292832 T C 4 168292836 A T 4 168292853 T A 4 168292864 T C 4 168292887 A G 4 169633306 C T 4 170812566 C T 4 171078557 T A 4 171774610 C T 4 178128578 G C 4 180339049 A G 4 181286425 C T 4 181509274 G C 4 183032807 A G 4 184807301 A G 4 185311508 T C 4 185311570 G A 4 185329052 G A 4 185350307 T C 4 185350422 A G 4 185779168 T C 4 185779461 C T 4 185779481 G A 4 185780254 G A 4 186485037 G A 4 187353180 A C 4 187353188 A G 4 187353199 G A 4 187353362 G A 4 187353388 C T 4 187353390 C A 4 187353437 G A 4 187353459 C T 4 187353485 C T 4 187353486 C G 4 187353487 G A 4 187353491 C T 4 187353497 T C 4 187353500 T A 4 187353508 A G 4 187353510 G C 4 187353510 G T 4 187353518 C G 4 187353520 A G 4 187353550 T C 4 187353554 A G 4 187353557 G C 4 187353610 C T 4 187353658 A G 4 187353818 A G 4 187354048 A G 4 187354174 G A 4 187354186 G A 4 187354197 T C 4 187354312 A G 4 187354335 T C 4 187354416 G A 4 187354429 A G 4 187354521 G A 4 187354542 A G 4 187354828 T C 4 187355027 G A 4 187356475 G C 4 187356484 G A 4 187356497 G A 4 187356955 T C 4 187356957 A G 4 187357003 G A 4 187357027 G C 4 187357036 G A 4 187357363 G A 4 187357369 T C 4 187357387 C T 4 187357415 T C 4 187357667 T C 4 187357686 G C 4 187357798 A G 4 187522112 C G 4 187522789 T C 4 187525910 A T 4 187525922 G A 4 187525940 A C 4 187525941 G T 4 187525946 A G 4 187525986 G A 4 187526002 C A 4 187533153 C T 4 187534689 G T 4 187535063 T C 4 187535765 T C 4 187631223 C T 4 189426841 A G 4 189426857 G T 4 189426863 C T 4 189426864 G A 4 189426871 C A 4 189426888 G C 4 189427370 G A 4 189427435 A T 4 189972360 A G 4 189972363 G A 4 189972366 A G 4 189972384 G A 4 189972492 A G 4 189972498 G A 4 189972501 A G 4 189972516 G C 4 189972897 G A 4 189972919 A G 4 189972930 A G 4 189972933 G A 4 189973230 A G 4 189973257 G A 4 189973266 A G 4 189973278 G A 4 189973949 T C 4 190197957 C A 4 190198002 A G 4 190198077 A G 4 190198080 T C 4 190198100 C G 4 190198107 G A 4 190198111 G A 4 190198121 C G 4 190198127 A G 4 190198142 T G 4 190198193 G C 4 190198201 G A 4 190198206 T C 4 190198214 C T 4 190198221 A C 4 190198225 T C 4 190198226 G A 4 190198377 C T 4 190198703 G A 4 190198707 G A 4 190198717 C G 4 190198844 T C 4 190199033 T C 4 190199199 T C 4 190859230 C G 4 190859289 A C 4 190859333 A G 4 190878827 T G 4 190899555 T C 5 19602 A G 5 223415 C T 5 225267 C A 5 226453 G A 5 233325 G A 5 233362 T G 5 233371 A G 5 236932 T A 5 254442 C T 5 254861 C G 5 649405 A G 5 649749 T C 5 650037 T C 5 650266 G A 5 650846 C T 5 651295 T G 5 1261052 G A 5 1266226 T C 5 1266310 A G 5 1271524 T C 5 1572585 A G 5 1594664 C G 5 1600771 A G 5 1600785 T C 5 1858062 T C 5 1858062 T G 5 1858821 A T 5 1858834 G C 5 2145174 T C 5 2145508 T C 5 2146102 G A 5 2146276 C G 5 2146338 T G 5 2146345 T G 5 2146527 C A 5 2146527 C G 5 2825568 C A 5 3659894 C T 5 3659913 G A 5 3659989 C T 5 3660487 A G 5 4225004 A G 5 4941345 A G 5 6272411 C A 5 6273004 G T 5 7447405 A G 5 7927332 C T 5 7927348 C T 5 7927356 C A 5 7927414 T G 5 7927952 G C 5 8061222 G A 5 8061279 G A 5 8061284 C G 5 10151085 T C 5 10151123 A G 5 10912625 T C 5 12056802 A G 5 12056837 C T 5 12056923 A C 5 12057204 A G 5 12058227 A G 5 13190185 T C 5 13847794 C T 5 14634747 A G 5 14634756 G A 5 15955155 C A 5 16535341 T C 5 17025201 G T 5 17353828 C T 5 17354234 C T 5 20166781 T C 5 20167136 T G 5 21293117 T C 5 21381238 G A 5 21381264 T G 5 21497311 C T 5 21497344 T G 5 22227645 A T 5 23242291 A G 5 23242685 T C 5 23304111 C T 5 23304211 G T 5 23304235 T C 5 23304261 G A 5 23304368 A C 5 23305356 G A 5 23305374 G A 5 23305484 T C 5 23527239 C G 5 23527919 A G 5 23528007 G A 5 24844076 G A 5 25007293 A G 5 25759642 G A 5 27795250 T A 5 28213790 A G 5 29312232 G T 5 29312728 G A 5 29312755 A C 5 29438592 G A 5 29438662 A C 5 29438664 T C 5 30972823 C T 5 31383964 A G 5 31384055 G A 5 31384509 C A 5 31840606 T C 5 32828846 T C 5 33466421 A G 5 33633582 G A 5 34206776 C T 5 35867204 A T 5 36170237 T C 5 36171420 G A 5 36172105 C T 5 36172115 G A 5 36176874 G A 5 36181617 A G 5 36181627 A G 5 36184284 C G 5 38943260 G T 5 38996638 A G 5 39021369 G A 5 39074696 C T 5 40320944 G C 5 40320945 G T 5 43053497 A T 5 43767400 A G 5 43803258 T C 5 44392401 G A 5 44585369 G C 5 44585815 C G 5 50058043 T C 5 51105168 G T 5 53835771 G A 5 54154481 A T 5 55781646 T C 5 55781772 T C 5 55782130 T C 5 56152795 G A 5 56161975 C T 5 56171391 G T 5 56175226 A G 5 56176306 T C 5 56183637 G C 5 56184444 T C 5 56803613 G A 5 58478599 C A 5 58478692 A G 5 58711707 G A 5 60860146 C T 5 62085252 G C 5 64957686 A G 5 64957718 T C 5 65349061 T A 5 65867918 C T 5 66219033 T C 5 66219117 T G 5 67569602 A G 5 67577051 G A 5 67584357 A G 5 67589914 G A 5 67590140 C A 5 67593016 T C 5 68417945 G T 5 68927608 G A 5 68927676 T C 5 69674512 G A 5 69927417 G T 5 71198806 C T 5 71542000 A G 5 72125176 A G 5 73231521 C A 5 73524903 A G 5 73524939 G A 5 73525404 G A 5 75041362 T G 5 76986580 C G 5 77991568 C T 5 80655266 T C 5 82205681 A G 5 82206152 G A 5 83378803 T C 5 83378919 G A 5 84637681 T C 5 85577284 C T 5 85586579 T C 5 85586584 C T 5 86865094 G A 5 89418018 A T 5 93798480 T C 5 93798817 A C 5 94572738 C A 5 95477855 A G 5 97441644 A T 5 97441664 A G 5 98851779 C T 5 98861253 A G 5 98913692 C A 5 98913961 T C 5 99069979 G A 5 99724591 C A 5 99733040 G A 5 99733085 A G 5 100695270 T C 5 102089175 G C 5 107267081 C T 5 107962193 C T 5 108535800 T C 5 110491533 C T 5 111184331 T C 5 111184434 A G 5 111699038 T C 5 111699088 A G 5 111699115 C A 5 111699641 C T 5 112043170 A C 5 112101793 C A 5 112151551 G T 5 112164862 G A 5 112171097 A G 5 112821283 A C 5 113797914 G A 5 114685700 T C 5 115106332 C G 5 115394388 A C 5 115394396 C G 5 115394857 A T 5 115394859 A G 5 115394869 T C 5 115394881 C A 5 115394908 C A 5 116051351 C T 5 117955311 T C 5 118952055 C T 5 122456440 T A 5 122609817 T C 5 124243030 C T 5 124243078 C T 5 125874804 G T 5 127638759 A G 5 128428722 A G 5 128428723 T G 5 128428851 C T 5 128500520 G A 5 131911847 G C 5 131925174 A C 5 131925187 T C 5 131944129 G A 5 131951996 T C 5 131953623 G A 5 131973177 A G 5 133784798 C T 5 134356380 G A 5 134583301 A G 5 134583302 C T 5 134583937 T C 5 135336981 A G 5 135979386 C T 5 137136265 A G 5 137787827 T A 5 140476395 T C 5 140476396 G T 5 140476653 G A 5 140476654 C A 5 140482102 A G 5 140482483 G A 5 140503443 C G 5 140531746 C G 5 140554189 G C 5 140554808 T A 5 140559532 G C 5 140564048 G C 5 140564088 C T 5 140568796 A G 5 140574045 C G 5 140581220 C A 5 140590766 A G 5 140595625 G A 5 140605030 T G 5 141392706 T C 5 143146391 C T 5 144135790 T G 5 144135871 T C 5 144604975 C T 5 145296020 C T 5 146320823 G T 5 146562965 A C 5 146562965 A G 5 148838021 G A 5 149433322 G T 5 149440644 C T 5 149440645 C T 5 149440723 G A 5 149440739 A G 5 149448060 G A 5 149457493 A G 5 149458110 C T 5 149458128 T C 5 149495770 G A 5 149497672 C T 5 149498759 A T 5 149498821 C T 5 149501803 C T 5 149512042 G A 5 149512781 G A 5 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G 6 51655796 T C 6 51656388 A G 6 51696056 A G 6 51696074 G A 6 51701484 G A 6 51713012 G C 6 51735613 T C 6 51750961 G A 6 51752241 C T 6 51889099 A T 6 51897565 C T 6 51909525 T C 6 51919253 G A 6 51927666 T C 6 51927683 T C 6 51929476 T G 6 51934976 C T 6 51934978 A C 6 51936717 C T 6 51936723 G A 6 51940816 T C 6 51949862 A G 6 52529666 A C 6 52529714 C G 6 52530205 C T 6 53047564 C T 6 54610711 C T 6 54610742 A C 6 54610783 C T 6 54611146 A G 6 56291176 G A 6 58199238 T C 6 58250570 A T 6 58263871 T C 6 58269738 G A 6 58270343 C G 6 58403634 T C 6 58404193 C G 6 58522197 C T 6 61993928 G A 6 62864433 A G 6 62864516 G A 6 63083740 T G 6 63083748 G T 6 63083774 A G 6 65331854 T C 6 65589020 G C 6 66446642 A G 6 67044197 G T 6 67044321 C T 6 67044663 T A 6 67804122 G T 6 67804186 T C 6 67804194 A C 6 67804202 G A 6 71721412 G A 6 71721445 T C 6 72563207 C T 6 72563211 G T 6 72563750 C T 6 73888146 C T 6 75056542 G A 6 75877044 A C 6 76051990 A G 6 77478497 C G 6 78345710 C T 6 79426986 G A 6 79427089 A G 6 81484692 G C 6 81669149 G C 6 82074113 T C 6 83480639 C T 6 83480720 T C 6 83545840 C A 6 83546246 G A 6 85070849 C T 6 85071341 A G 6 85140178 A C 6 85140313 C A 6 85140399 G A 6 88608057 A G 6 90012435 G A 6 91210640 A G 6 91682066 C T 6 92363395 A C 6 92838614 C T 6 93100978 G A 6 93100980 T C 6 93901330 A G 6 94555470 A G 6 96348615 T G 6 97077504 C A 6 101332215 T C 6 101849962 C A 6 105089423 A G 6 108028709 T C 6 108028752 T A 6 108028757 T G 6 108774766 C G 6 109051552 C T 6 109051652 T C 6 109507842 A T 6 110252356 G C 6 110252919 C A 6 110252987 A G 6 110911774 C T 6 111871080 T C 6 112375307 A G 6 112375889 A G 6 112524506 T C 6 112677375 C A 6 113203779 G A 6 113940257 G T 6 114262015 A C 6 114265754 A G 6 114405657 G C 6 114405704 A G 6 115322919 G A 6 115398931 G C 6 116787050 C T 6 116787688 C A 6 117609387 T C 6 117622521 T A 6 117629650 A T 6 117629663 T C 6 117631666 T C 6 117639104 T C 6 117639153 T C 6 117639620 G T 6 117657400 A G 6 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145806936 C T 6 145807010 G A 6 146350563 C A 6 147729477 T G 6 148516642 T G 6 149237845 A C 6 149237889 A G 6 149237931 G A 6 149700805 G A 6 151364186 A G 6 151646048 G A 6 152129746 G T 6 152201624 G A 6 153065996 G A 6 153066078 T G 6 153523383 A G 6 153523425 G A 6 154478704 C T 6 154629327 C T 6 156301661 G T 6 156301726 C T 6 156938505 T C 6 156938506 A G 6 156938539 T C 6 157150145 G A 6 157256310 C T 6 158024313 T C 6 158024403 C G 6 158024861 C A 6 158024868 C T 6 159190019 T G 6 159947789 C T 6 160398330 C T 6 160547249 G T 6 160548433 A G 6 161771412 T C 6 161970231 T A 6 161990678 C T 6 162206577 T G 6 162474893 A G 6 162475434 A C 6 162622550 C T 6 165404863 A C 6 165404917 A G 6 165722345 T C 6 166204195 T C 6 166204288 G A 6 166695194 T C 6 167411008 T C 6 167411334 C T 6 167411337 G A 6 167411388 C G 6 167411401 C T 6 167411616 C T 6 167589680 C T 6 167792111 G A 6 167792114 G A 6 167792651 C G 6 167792671 C G 6 167792694 G C 6 167792699 G A 6 168687802 C G 6 168687815 A C 6 168687819 C A 6 168687828 G A 6 168735290 A G 6 168735309 A C 6 168735311 T A 6 169313243 A G 6 169795962 G T 6 170470548 T A 6 170470568 A C 6 170470778 C A 6 170528622 A G 6 170529546 A G 6 170529549 G A 6 170529566 C T 6 170529587 T C 6 170529638 T C 6 170530453 T C 6 170530506 C T 6 170530518 A G 6 170530559 T C 6 170530838 C T 6 170530873 C T 6 171026382 T C 6 171026394 T C 7 746314 A G 7 746705 A G 7 746706 C A 7 1883274 T C 7 2004124 C T 7 3155087 T C 7 3155089 T G 7 3155579 C T 7 3155651 C G 7 4320984 A G 7 4321571 A G 7 5156760 G A 7 5946901 G C 7 6013049 C G 7 6018444 A G 7 6018592 G A 7 6022178 G C 7 6029748 C T 7 6035428 A C 7 6035507 C T 7 6038483 G A 7 6039129 T C 7 6041897 T C 7 6042522 C T 7 6043057 A G 7 6043065 C T 7 6043112 C T 7 6045881 C T 7 6045934 T C 7 6048359 C T 7 6048804 G C 7 6048845 A G 7 6048973 C A 7 6414545 C T 7 6431404 G T 7 6431420 C A 7 6431933 C G 7 6441258 G A 7 6442371 G A 7 6776537 G A 7 6776585 C T 7 6777726 T C 7 6777752 T C 7 6777768 T G 7 6777780 T G 7 6777784 A G 7 6777820 T G 7 6777821 G A 7 6785956 A G 7 6786731 C T 7 6790900 T C 7 6791040 G C 7 6919565 T C 7 6974986 G A 7 6975272 G T 7 6975316 G T 7 6975366 C A 7 8549008 G A 7 8549058 G A 7 8549477 C T 7 10013659 G A 7 10897044 T C 7 10897594 C A 7 10897594 C G 7 11349162 C T 7 11349705 G A 7 11349733 A G 7 11349735 T C 7 12122025 C T 7 12510929 A C 7 12511312 G A 7 14868954 C T 7 16297567 C T 7 17006944 G C 7 17007526 G T 7 17514653 T C 7 18318662 C T 7 18624673 G A 7 18625440 C T 7 19184257 C G 7 21206385 A G 7 21764077 A G 7 21764081 G A 7 22327627 G A 7 22328109 C T 7 22947858 A G 7 22948438 G C 7 24353194 A C 7 24353195 C T 7 24353267 C T 7 25233745 C G 7 25233789 G C 7 26627952 G T 7 26627954 G A 7 29464865 T C 7 30177268 G A 7 30177278 C T 7 30855318 G A 7 30855926 G C 7 32133424 G A 7 32512110 A T 7 33101967 C T 7 33102514 G A 7 33193313 A C 7 33193314 T C 7 34540399 G T 7 35083870 T C 7 35084552 C T 7 35084572 C T 7 35084601 T C 7 36186371 G C 7 36858622 G A 7 36858643 A G 7 37415057 G A 7 37708712 A G 7 39807352 G A 7 40320747 G C 7 43874751 A G 7 44026116 T G 7 44056757 C T 7 44057222 C G 7 45256549 A G 7 45256975 A G 7 45828285 C T 7 45847880 A G 7 45856902 T C 7 45856916 G A 7 45857319 G A 7 45857848 G A 7 46028450 C T 7 46028459 C T 7 46643720 A C 7 50470256 G A 7 50745025 G A 7 51450917 G A 7 51450951 A G 7 51451225 T C 7 51451275 G A 7 51451291 C T 7 51451376 A G 7 51451655 G A 7 51451775 T C 7 51451925 C T 7 51451928 T C 7 51451955 G T 7 51452002 A G 7 51452050 G A 7 51452088 T C 7 51452279 A G 7 51824545 C T 7 51824890 T C 7 51824990 A G 7 52225367 T C 7 52758842 T C 7 52759429 A G 7 53189193 A G 7 53189634 G A 7 53190434 G T 7 53190453 A G 7 53190508 A G 7 53190917 C T 7 53203065 G A 7 53718464 T C 7 53718485 G T 7 53854735 T A 7 53854969 T C 7 54618943 A G 7 55210733 G C 7 55219290 T C 7 55219307 C G 7 55221447 C G 7 55225140 G C 7 55232726 G T 7 55248787 T C 7 55259948 C G 7 55658927 T C 7 55659085 T C 7 55806087 G T 7 55806093 G T 7 56405132 T C 7 56430969 C G 7 56430977 G C 7 56430980 C A 7 56431109 A G 7 56431170 A G 7 56431807 G A 7 56432242 T C 7 56635995 C A 7 57289345 C T 7 57603890 T G 7 57603918 G A 7 57669433 G T 7 57669986 A G 7 57809151 C A 7 57832849 T C 7 57938126 A G 7 57938210 T C 7 61058809 T G 7 61059081 A G 7 61063424 G A 7 61063551 A G 7 61071095 A T 7 61071103 C T 7 61071188 G T 7 61071203 C T 7 63206179 A G 7 63206611 A G 7 63206623 G T 7 63229281 G A 7 63229377 C T 7 63229524 T C 7 63230106 C T 7 63230147 C T 7 63230155 G A 7 63602429 G A 7 63602520 A G 7 63602542 T C 7 63635236 A C 7 63635239 G C 7 63635241 A G 7 63635248 T C 7 63635271 C G 7 63635272 T C 7 63635286 C T 7 64583576 C G 7 64583585 C T 7 64583587 C T 7 64583615 G C 7 64583628 C T 7 64652748 C G 7 64652982 T G 7 64653060 G A 7 65037658 C G 7 65037683 T C 7 65059071 A G 7 65082869 G A 7 65163375 C G 7 65163587 T C 7 65432962 G A 7 65552792 A T 7 65971428 G T 7 66355416 C T 7 66457975 T C 7 66458627 A G 7 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G A 10 43620134 C T 10 43691691 C T 10 45406608 T C 10 45652138 T C 10 45652447 A G 10 45652504 T G 10 45652579 A G 10 45922190 G A 10 46195321 T G 10 47152194 G A 10 47152364 A G 10 47170635 A T 10 47707447 G A 10 47707459 T C 10 47729649 C T 10 47739153 A G 10 47750099 G T 10 47768664 T C 10 47768722 T C 10 49218034 G A 10 49218414 C A 10 49218451 G A 10 49218561 G C 10 49240255 A G 10 49240259 C A 10 49872724 C A 10 50013531 A G 10 50013580 C T 10 50013594 C T 10 50534599 G A 10 50534646 C T 10 51486999 G A 10 52438586 G A 10 52438599 G A 10 52439039 G A 10 52467072 G A 10 52537198 C T 10 53615000 T C 10 54171342 G T 10 54171478 A T 10 54171706 G T 10 54228504 G T 10 54228515 A G 10 55422826 G T 10 56915486 C T 10 56915523 G A 10 56915531 A T 10 58941173 C T 10 59342734 T A 10 59343246 A C 10 60228964 G A 10 61956912 C A 10 63723336 T C 10 63723440 A C 10 63723909 C T 10 64703524 C T 10 66488391 G T 10 67598587 C T 10 68498439 A G 10 70342096 G A 10 70836869 T G 10 71582636 T A 10 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113753096 T C 10 114488065 G A 10 114591047 C G 10 115475804 A G 10 115548915 A T 10 115548971 T A 10 116006120 C T 10 116006247 T C 10 116180554 C T 10 117486391 G T 10 117810868 G A 10 118147645 A G 10 118147665 T C 10 118148153 A C 10 118525028 A T 10 118525526 T C 10 119243364 C T 10 119243810 T A 10 120403436 C T 10 120766000 A G 10 120766163 T A 10 121050776 C T 10 121050852 G A 10 121050965 G A 10 121162095 T C 10 121631812 C G 10 122520364 C T 10 123246612 G A 10 123345664 C T 10 123358170 C T 10 123358273 C T 10 123862546 C T 10 123862547 A G 10 124573552 T C 10 124573574 C T 10 125310002 C T 10 125310499 G A 10 125757093 C T 10 126195810 G A 10 126195824 C G 10 126196558 G C 10 126741574 C T 10 127349999 A C 10 127846669 C T 10 127846703 C T 10 127846720 T C 10 127847387 T A 10 128227832 T C 10 129339809 G A 10 129340335 T C 10 129650290 G A 10 129650996 A G 10 131265852 C T 10 131506546 G A 10 131557867 A G 10 131557933 G A 10 131564809 G A 10 131565509 G A 10 132295030 A G 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T G 11 49844746 G C 11 49844747 T C 11 49867489 A C 11 49867490 A C 11 49868030 A G 11 49868050 G C 11 49868051 G A 11 49878757 G T 11 49878885 T C 11 49878894 G A 11 49878896 A G 11 49878899 G C 11 49908279 G C 11 49908382 G A 11 49908392 C A 11 49908581 T C 11 49908583 C T 11 49908586 C A 11 49908592 A G 11 49908840 A G 11 49908856 A C 11 51483215 C T 11 51483747 G C 11 51515460 C T 11 51515640 A G 11 51516257 A T 11 54934563 C T 11 55035985 G A 11 55036233 C T 11 55049986 C A 11 55050558 T C 11 55071967 T G 11 55072428 C T 11 55532244 T C 11 55532303 T C 11 55532334 A G 11 55532908 A T 11 56517716 G A 11 60264755 G A 11 60265322 T C 11 60804962 G A 11 61456160 C T 11 61731977 G A 11 61773679 C T 11 62098295 T A 11 62914125 G A 11 63817799 G C 11 64574200 G A 11 65793121 C T 11 65793797 G A 11 67564437 A G 11 67564738 G A 11 67568487 C T 11 67570639 C T 11 67571091 T A 11 67714122 C G 11 67726415 G A 11 67931735 A G 11 67931761 G A 11 69457547 C T 11 69459046 A G 11 69465681 A G 11 70424188 G A 11 70857741 A G 11 71347185 T C 11 71349215 G A 11 71349372 G A 11 71349527 T G 11 71349654 G A 11 71349696 T C 11 71360446 G A 11 71399927 C T 11 71400609 T C 11 71477298 T C 11 71477335 C G 11 71502424 G A 11 71502531 G C 11 71502886 G A 11 71502930 A G 11 71506814 A T 11 71615069 G A 11 75432864 A G 11 75432886 G C 11 75432903 G A 11 76169644 A G 11 76170687 C T 11 76239148 G A 11 76239150 C T 11 76239160 A G 11 76250374 G A 11 76515087 G C 11 76515105 C A 11 77776590 G C 11 77777188 C T 11 78447534 T C 11 80555975 G C 11 80556380 T C 11 81258169 T C 11 81258185 C T 11 83261268 C T 11 83261334 C T 11 83261851 A G 11 83580202 A C 11 87079863 A G 11 88211600 T C 11 89487612 G A 11 89609220 T C 11 89609260 G A 11 89795691 G A 11 90372636 G A 11 90972900 C A 11 90973362 T C 11 90973418 G A 11 91680278 T C 11 92623608 A G 11 93754508 G A 11 94180115 G C 11 94200690 C G 11 94203353 G A 11 94213155 C G 11 94759059 A G 11 94782500 C G 11 94782501 A G 11 94782515 C A 11 95040632 C A 11 95041189 C A 11 95041230 C T 11 95532166 A G 11 95550810 C G 11 95561488 T G 11 95562771 T C 11 96852915 A T 11 97332219 G A 11 98998719 G C 11 99216940 T G 11 99217421 T C 11 99865248 A G 11 99865266 C A 11 99865868 T C 11 100921941 T A 11 101217386 A T 11 101217962 A G 11 101465270 A G 11 101981463 G T 11 101984628 C T 11 102079986 G A 11 102100199 C T 11 103416881 T C 11 103416913 T G 11 103542664 A G 11 104013175 A G 11 104013263 A T 11 105724696 C T 11 106318163 T C 11 106692416 G A 11 107669817 C T 11 107669894 C T 11 107670383 C G 11 107670446 A G 11 107670459 A G 11 108106782 C T 11 108158134 T C 11 108163733 A G 11 108165406 G A 11 108165407 C G 11 108170271 G A 11 108196509 G C 11 108204881 C T 11 110016032 A G 11 110016519 T G 11 110712255 A T 11 110712847 C G 11 114092153 C A 11 116732856 A G 11 117343197 T C 11 117956263 C T 11 117956338 G T 11 117956409 T C 11 117956943 A G 11 118362869 T C 11 118567444 A G 11 118567486 T C 11 119145274 A G 11 119167448 T G 11 119168370 G A 11 120440043 A G 11 120508093 C T 11 124455318 T C 11 125497247 T C 11 125497342 A G 11 125505095 C G 11 125507676 C T 11 126666122 C T 11 128240874 A T 11 128240927 G C 11 130416523 C T 11 130417076 G A 11 130417573 A G 11 131350351 C G 11 131350968 G A 11 134916463 G A 11 134916479 C T 11 134916495 T C 11 134917197 G A 12 420429 G A 12 427077 G A 12 433151 A G 12 442354 T C 12 443085 C A 12 443795 T C 12 460226 C T 12 461637 C T 12 464123 A G 12 471826 C T 12 474797 T C 12 494762 G C 12 528452 A T 12 528865 A C 12 528887 A T 12 530660 T A 12 530660 T G 12 1194236 A G 12 1194372 A G 12 1194777 A G 12 1196938 A G 12 1200335 G A 12 1899291 T A 12 3379076 G A 12 3567611 T C 12 4445722 G A 12 4553184 C T 12 5082261 A G 12 5082274 C T 12 5082302 A G 12 5082835 A G 12 5748011 T C 12 5748052 C T 12 5748078 A G 12 5748079 A G 12 6697842 A G 12 6704213 T A 12 7808545 A G 12 8387026 G A 12 8387543 C T 12 8391144 C G 12 8391162 T C 12 8391761 C T 12 8393255 G A 12 8393268 A G 12 8393274 T C 12 8393314 G A 12 8393803 C T 12 8544062 A G 12 8544083 G A 12 8544541 C T 12 8550134 C T 12 8552680 T C 12 9451473 G A 12 9451541 C A 12 9451818 T C 12 9585578 C T 12 9585658 A G 12 9848883 A G 12 10854878 A G 12 11174753 G A 12 11174795 T G 12 11201629 G A 12 11230403 T C 12 11230436 G A 12 11230437 A C 12 11230452 C A 12 11230457 C G 12 11230465 C T 12 11230496 G A 12 11230497 G A 12 11230520 G A 12 11230542 A C 12 11230544 C T 12 11230554 G A 12 11230566 G A 12 11230578 T C 12 11230583 T C 12 11230592 C G 12 11230597 G A 12 11230598 C T 12 11230601 C T 12 11230609 G A 12 11230636 T G 12 11230662 C T 12 11230665 G A 12 11230700 G C 12 11230701 G A 12 11230712 C T 12 11230726 C T 12 11230744 A T 12 11230752 T A 12 11230754 C T 12 11230775 A C 12 11230778 A C 12 11230832 A C 12 11230834 T C 12 11230867 T A 12 11230873 T G 12 11230890 C G 12 11230895 A T 12 11230909 A G 12 11230936 A T 12 11230948 A G 12 11230968 A G 12 11231002 C A 12 11231008 T C 12 11231018 G A 12 11231042 A G 12 11231052 G A 12 11611304 G A 12 11611331 C T 12 11611336 G A 12 11611368 C T 12 11611377 T C 12 12027745 A C 12 13370236 A C 12 13555619 G T 12 13555639 C T 12 13556252 G C 12 15138281 A G 12 16397411 A G 12 17757557 C A 12 20177190 C T 12 21616558 G A 12 21616598 C T 12 21617144 A G 12 21617145 A G 12 22193228 G A 12 22957461 A G 12 22957519 G A 12 23192806 T C 12 24358865 C T 12 25363085 C T 12 25368084 T C 12 26504062 C G 12 29688497 T C 12 30359821 T C 12 31242271 G A 12 31508019 G C 12 32741558 A G 12 33074174 A G 12 33074256 T G 12 37971347 G C 12 38600609 G A 12 40879387 A G 12 40880558 A T 12 40880586 A G 12 40880587 T A 12 40880831 A T 12 40880924 A G 12 40881916 T A 12 40881964 G A 12 40881967 C T 12 40881986 G A 12 40882000 C G 12 40882006 T C 12 40882016 G T 12 40882026 A G 12 40882071 C G 12 40882121 G T 12 40882450 G C 12 40882490 A G 12 40882522 C A 12 40882649 G T 12 40882701 G T 12 40883092 C A 12 40883745 C A 12 40883775 C T 12 40883781 G A 12 40883786 T A 12 40883904 G A 12 40884061 C T 12 42477389 T A 12 42477390 A C 12 42477397 A G 12 42477402 T C 12 42477404 T C 12 42477426 A G 12 42477431 C T 12 42477930 C T 12 42477945 A G 12 42477948 T G 12 42477951 T C 12 42477952 G A 12 42477962 C T 12 42477979 G C 12 42478001 T G 12 43965011 A T 12 43965108 T A 12 45228464 C T 12 46665157 G A 12 46955423 C T 12 51213765 T C 12 52698224 C T 12 52698226 A G 12 52698228 T G 12 52698230 C T 12 52698235 G T 12 52698236 C T 12 53346750 C T 12 53512756 A T 12 53512770 G T 12 54087418 C T 12 54476772 G A 12 54501012 G C 12 55828540 C T 12 56473808 T C 12 56474480 A G 12 56478002 A C 12 56481118 G A 12 56488913 G A 12 57489828 C T 12 57544620 C T 12 58141602 C T 12 60103232 G A 12 60553810 C T 12 61969925 T C 12 62524923 A G 12 62525409 A T 12 63503650 T G 12 64798118 C G 12 68551409 C T 12 68946720 C T 12 69202580 T G 12 69203312 G A 12 69207162 G A 12 69222357 C A 12 69230189 G T 12 70074807 G C 12 71520477 A C 12 71520600 T C 12 71521068 G T 12 72372601 C T 12 72979069 T A 12 72979099 T G 12 73501997 T G 12 76633769 T C 12 77056710 A G 12 79575315 T A 12 79575325 C A 12 82670236 C T 12 83471875 G A 12 83545935 C T 12 84356493 G A 12 85165573 A T 12 86084416 G T 12 87490519 G T 12 87490552 T C 12 88925973 T C 12 88939790 T C 12 88973732 A G 12 88974212 A G 12 89490962 T C 12 89491013 G A 12 89864432 T A 12 90270430 G C 12 91851148 T A 12 92997562 C A 12 94372056 C G 12 95012735 A G 12 95602672 C T 12 96161299 T C 12 96161309 G T 12 96161410 A T 12 96161868 G C 12 96161887 G C 12 96848128 C T 12 96848651 C T 12 96848682 A G 12 97799632 G A 12 97799634 C T 12 97800208 T C 12 97800239 C T 12 98984651 A G 12 98985056 T C 12 99265981 A G 12 99266022 A T 12 101215628 G A 12 102361086 T A 12 104959816 T A 12 105079958 T C 12 105673808 G A 12 106114632 G A 12 106620432 A G 12 107381892 C T 12 108168706 G A 12 109330915 G A 12 112241402 G A 12 112843998 A T 12 112856643 G A 12 112890776 A G 12 112942353 G A 12 114501664 T C 12 114501692 T C 12 114501693 G A 12 114501708 T A 12 114501726 C T 12 114501852 A T 12 114501869 A C 12 114501990 A G 12 114502105 T A 12 114502125 T C 12 114502197 T C 12 114502242 A G 12 114502276 A C 12 114502702 G T 12 115184053 G C 12 115866519 G T 12 116050988 C T 12 117193050 T C 12 117692072 T C 12 118256945 G C 12 118256995 T A 12 121426478 C T 12 121433816 C T 12 121433844 A G 12 121434833 G A 12 121876257 G T 12 121876385 G C 12 121876866 G A 12 122849392 A C 12 123186539 A G 12 123186610 G A 12 123186611 C G 12 123199745 T C 12 123199755 A G 12 124804371 G C 12 124804373 C T 12 124804522 A C 12 124804538 G A 12 124804550 C A 12 124804566 G A 12 124804578 C A 12 124804593 G C 12 124804644 A G 12 125177433 C T 12 125177454 G A 12 125177986 C T 12 127490326 A C 12 128958147 A G 12 129299134 T C 12 130876953 T C 12 130876961 G T 12 130876987 T C 12 130877140 G T 12 130877166 T C 12 130877287 G A 12 130877325 A G 12 130877332 G A 12 130877408 C T 12 130877506 A G 12 130877521 G A 12 131017991 C G 12 131966057 T C 12 131966293 C T 12 132286104 C T 12 132286105 G A 12 132286113 T C 12 132286133 G A 12 132957443 T C 12 132958490 A G 12 132959437 G A 12 132959439 G A 12 132959472 T A 12 132959689 C T 12 132959693 T C 12 132959732 T C 12 132961351 G T 12 133201947 T C 12 133208611 A G 12 133209593 T C 12 133209653 C T 12 133209660 G A 12 133212165 A G 12 133235577 A C 12 133241144 C A 12 133243788 T A 12 133243817 C T 12 133250569 T G 12 133250571 C T 12 133254529 C G 12 133255792 A C 12 133258088 C T 12 133818115 C T 12 133818696 G T 13 19098169 G A 13 19098189 T C 13 19196854 T C 13 19196952 A G 13 19196957 A G 13 19196999 A G 13 19197003 T C 13 19197028 A G 13 19197050 A C 13 19197108 G T 13 19197161 T C 13 19197162 G A 13 19312986 G A 13 19312997 T C 13 20006231 A C 13 21517666 C T 13 21535954 C G 13 22638746 G A 13 23269969 T A 13 23516337 C T 13 23533834 T G 13 23534184 T C 13 23534203 G A 13 23534230 C G 13 23534298 G A 13 24958840 C G 13 25244216 C G 13 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T C 13 50466766 C T 13 50466771 A G 13 50466774 G A 13 50466780 C T 13 50466781 A G 13 50466783 C G 13 50935593 C T 13 51230621 A G 13 51231117 C T 13 51231132 G C 13 51685479 C T 13 51685541 C T 13 51686109 G A 13 52482451 G A 13 52602919 A C 13 60909992 G A 13 61266375 T C 13 61651695 T A 13 61652128 T C 13 62884880 A G 13 62885397 T C 13 62885404 C G 13 63984445 G A 13 63984474 C A 13 63984474 C T 13 63984519 T C 13 68406302 A G 13 68406306 A G 13 68406761 G A 13 68820749 C T 13 68820783 A G 13 69675780 G A 13 69675935 T C 13 70884365 C G 13 70884372 T C 13 70884412 G A 13 70884937 T C 13 70885012 C T 13 71158022 T C 13 71498321 T C 13 71498338 C T 13 71498343 G T 13 71498360 G C 13 71498385 C T 13 71498894 A G 13 72477265 C T 13 74077481 C T 13 74549292 T C 13 76333853 G A 13 76583319 A T 13 77614202 G A 13 77614206 A T 13 77614213 C T 13 78800795 G A 13 79015424 G A 13 79775160 C T 13 80384592 G A 13 80384594 A T 13 82485701 G A 13 82641070 G T 13 83720107 C G 13 85714107 T C 13 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T 13 112803842 A G 13 112803853 T G 13 113498860 C T 13 114089046 C T 13 114089082 C T 13 114089113 A G 13 114089128 T C 13 114089164 C T 13 114089330 G A 13 114089440 G C 13 114089675 G T 13 114089876 A G 13 114089888 T C 13 114089891 A G 13 114089897 C T 13 114090025 C T 13 114090109 C T 13 114090253 T C 13 114090689 G A 13 114091321 T C 13 114838339 C T 14 19491761 T C 14 19629734 C G 14 19688223 G A 14 19688480 G C 14 20084306 C T 14 20084444 G C 14 20086576 G A 14 20140628 C G 14 20140803 G C 14 20140905 C T 14 20414407 C A 14 20414410 T C 14 20414737 C T 14 20414884 G A 14 20811577 A C 14 20811577 A G 14 20811578 A G 14 20811588 T C 14 20812951 G A 14 20815313 A G 14 20822772 C T 14 20826243 A C 14 21236526 T C 14 21237137 G A 14 21630781 C T 14 21860360 G A 14 21863716 C T 14 21871999 T G 14 21875487 T C 14 21894526 T C 14 22320158 C A 14 22320728 T C 14 22371221 G T 14 22371246 A G 14 22746792 C T 14 23029407 T C 14 23029409 T C 14 23029512 G C 14 23029525 A T 14 23652708 T A 14 24436511 T C 14 24436706 G C 14 24436798 G T 14 24473786 C A 14 24526287 G C 14 24526895 G A 14 25515815 A G 14 25515822 T C 14 26605655 T C 14 27314804 C T 14 27855023 T C 14 27855025 C T 14 31919287 T C 14 36351085 G A 14 36417424 G A 14 36417426 T A 14 36417451 G A 14 36417453 T A 14 36417478 A G 14 36417480 A T 14 36417498 T C 14 36417545 C T 14 36417546 A G 14 36417559 G A 14 36417572 T C 14 36417640 G A 14 36417696 A T 14 36417716 T C 14 36417723 A T 14 36417741 T C 14 36417743 T C 14 36417761 C T 14 36417777 A T 14 36417802 A G 14 36417804 A T 14 36417842 T C 14 36417883 A G 14 36417957 T C 14 36417959 T C 14 36418031 T C 14 36418355 T C 14 36419122 C A 14 36419133 T G 14 36989596 A G 14 36989696 G T 14 38639257 C T 14 39354900 C G 14 39858941 A G 14 41413712 C T 14 42835190 G A 14 45027200 G T 14 46316764 A G 14 47492399 C G 14 47562483 T A 14 48921178 T C 14 50520782 A G 14 52229607 C G 14 52229678 T C 14 52230158 T G 14 52519254 A G 14 52519839 G A 14 55880730 A G 14 55880918 A G 14 55921280 A G 14 56232970 T C 14 56233561 G A 14 56548918 C A 14 57463704 G A 14 57586697 C T 14 57586731 T G 14 59170024 C G 14 62003902 C T 14 62983672 A T 14 65473196 G A 14 65568563 C T 14 65733329 A T 14 65733701 A G 14 65734110 C G 14 65734181 C G 14 65734600 G A 14 65934921 T C 14 68291907 G A 14 68352323 A G 14 68354152 C T 14 68758317 T C 14 68934690 A G 14 68944147 T G 14 68944245 T C 14 70440081 T C 14 71632622 C T 14 71632640 C T 14 72266238 T A 14 72736899 G A 14 73047284 A G 14 73997686 G A 14 74025873 A T 14 75506875 G A 14 77101088 A G 14 77704974 G C 14 78149486 T C 14 78149563 G C 14 79217473 C T 14 80002042 A G 14 80002096 T C 14 80002632 A G 14 80874274 A T 14 81554617 A G 14 81558640 C G 14 81559221 G A 14 81562808 A G 14 81606422 G T 14 81606503 T C 14 81610869 C A 14 81610942 C T 14 82053802 T C 14 82054300 G T 14 82602590 C T 14 82603182 C T 14 86166491 A G 14 88199938 T C 14 91507280 T C 14 94339436 C G 14 94845040 G A 14 95389462 A G 14 95582544 A C 14 95600006 G C 14 95600072 T G 14 96092282 C T 14 96592735 C G 14 97107413 G A 14 98485583 T C 14 98486120 G A 14 98868717 G A 14 100595278 T A 14 100595880 G A 14 101134984 G A 14 103050106 G A 14 103050397 C G 14 103840494 G A 14 104168701 C T 14 104563874 C T 14 104563932 G T 14 104564283 T C 14 104564345 G A 14 104564410 T C 14 104564412 G A 14 104945518 C G 14 104945694 A T 14 105243435 G T 14 105246872 A G 14 106049449 T C 14 106167913 T A 14 106725276 G A 14 106725315 G A 14 106725329 C T 14 106725339 A G 14 106725346 G A 14 106725515 A C 14 106725525 C A 14 106725526 T A 14 106725543 A T 14 107046720 T A 14 107048702 G A 14 107048749 C G 14 107048929 T C 14 107112165 C G 14 107112665 A C 14 107130943 G A 14 107130971 C T 14 107131063 A G 14 107131164 A C 14 107131246 C T 14 107131290 T C 14 107131300 T C 14 107131301 C G 14 107131349 A G 14 107131357 T C 14 107131410 A G 15 20148695 G T 15 20148878 C A 15 20319405 C T 15 20319448 T C 15 20543982 T C 15 20543988 A G 15 20635860 C T 15 20891413 A C 15 20891478 C T 15 20891489 T C 15 20891547 C T 15 20891566 C A 15 20891566 C G 15 20891651 A G 15 20891867 G T 15 20891893 C A 15 20966938 G T 15 20967029 A G 15 21136727 T A 15 21136951 G A 15 21136968 C T 15 21137321 C A 15 21325716 C T 15 21325857 T C 15 21326120 C T 15 21326788 C G 15 21966878 C T 15 21973528 C T 15 21973529 A G 15 21973572 T C 15 21973587 T C 15 21973588 A G 15 21973592 G T 15 21973797 T C 15 21973842 A C 15 21973843 G A 15 22148127 C T 15 22148775 A G 15 22148845 A G 15 22151298 C T 15 22151704 A G 15 22151876 C T 15 22822510 G C 15 22822568 T G 15 22822751 C G 15 22822755 G A 15 22822854 T A 15 22822955 G T 15 22823001 T A 15 22823078 A G 15 22823113 T C 15 22823116 C A 15 22823137 A C 15 22823185 T G 15 22823255 A C 15 22823692 T C 15 22823783 G T 15 22823838 C A 15 22823855 A G 15 22823949 C A 15 22823963 T C 15 22824021 T G 15 22824030 C A 15 22824086 G A 15 22824376 A G 15 22826375 T C 15 22826634 A C 15 22826679 C T 15 22826764 T C 15 22827002 G C 15 22827233 A G 15 22827239 G C 15 22827251 A C 15 22827293 C A 15 22827319 G T 15 22827322 A T 15 22827437 A G 15 22827816 A C 15 22827928 T G 15 22827930 C A 15 22827939 T C 15 22827984 G C 15 22827985 G A 15 22828037 G A 15 22828041 A G 15 22828139 A T 15 22828145 T C 15 22828147 T C 15 22828275 G C 15 22828390 A T 15 22828465 A C 15 22829674 C G 15 22829687 G T 15 22829695 C T 15 22830185 T C 15 22830340 C T 15 22830453 G A 15 22830504 T A 15 22830510 G T 15 22830571 C T 15 22830577 A G 15 22830592 G T 15 22830847 C G 15 22830891 T C 15 22830899 G T 15 22830903 G C 15 22830990 C T 15 22830999 C T 15 22832977 A G 15 23782545 T C 15 24059444 T A 15 24059493 A T 15 24060123 T G 15 24060127 G A 15 24506371 C A 15 24506572 C T 15 24672192 G T 15 24672267 G C 15 24672440 G C 15 24672460 A C 15 24672460 A T 15 24672504 G C 15 24672554 G T 15 24672804 T A 15 24722807 G T 15 24722823 G C 15 24722829 G A 15 25414653 C T 15 26273690 G A 15 26274261 A G 15 26600681 A G 15 26601246 G A 15 26601264 G A 15 29717391 T C 15 31490709 A C 15 31821275 G A 15 32535526 G A 15 34638030 C T 15 34639823 A G 15 34639826 A G 15 34639879 C G 15 34639904 G A 15 35147136 C A 15 35147592 G A 15 35384908 C A 15 37292823 G A 15 37292836 G A 15 38190654 G T 15 38545725 A C 15 38617282 A G 15 38642971 G C 15 38643009 G A 15 38643031 C T 15 39034864 C T 15 39034914 G A 15 40457042 A C 15 40457635 C T 15 40998305 T A 15 41011311 G A 15 41021280 C G 15 42265586 G A 15 43853068 C A 15 43853127 C T 15 43853145 G A 15 43853167 T C 15 43853196 C G 15 43853216 T A 15 45985719 G C 15 47150907 T C 15 49220457 A G 15 49615149 A G 15 51483996 G C 15 53022863 A C 15 53023345 C T 15 53178383 C G 15 54607264 T C 15 55099758 G T 15 59722664 C T 15 59844728 A G 15 59845138 G A 15 62046728 T C 15 66736741 C T 15 66774559 A G 15 67458930 C T 15 67476735 G A 15 67476756 C T 15 67476768 C T 15 67477450 C T 15 68123700 C T 15 69383465 T A 15 69676000 C A 15 70292710 C T 15 70573650 C A 15 71967893 G A 15 74460734 C T 15 74654146 T C 15 76001037 C T 15 76039262 T C 15 78206482 C T 15 78206514 A T 15 78206928 G A 15 78206970 G T 15 78206973 C A 15 78207027 A G 15 79032355 T C 15 79032469 C T 15 79155412 T C 15 79526411 G T 15 80012735 A G 15 81410106 G A 15 82636963 G A 15 82637357 T C 15 83331487 T C 15 83569832 C G 15 84143244 G A 15 84857013 C G 15 84909385 G A 15 84951508 C A 15 84951578 G C 15 85052414 C T 15 85495400 C T 15 85495950 C T 15 85788238 G A 15 85788607 C T 15 85788735 T C 15 86855520 G A 15 88428702 C A 15 88472170 A G 15 88483594 A G 15 88680100 G A 15 88680987 T A 15 88690951 C T 15 88726405 G A 15 88727751 A T 15 89801677 G C 15 89811482 T C 15 89821732 G A 15 89824258 A C 15 89833165 T C 15 89836793 C A 15 89843950 A T 15 89855998 C T 15 89859377 A G 15 90628777 T C 15 90631247 G A 15 90633416 A G 15 90645265 G A 15 91290366 G C 15 91337208 G A 15 91347135 C A 15 91347755 A G 15 91347784 C T 15 91352774 A G 15 91969961 G C 15 91969970 T G 15 91969976 C G 15 92868324 A G 15 94208914 A C 15 95270619 C T 15 95270626 T C 15 95271164 T A 15 95662895 T A 15 96479346 C T 15 96705724 T C 15 97586395 C A 15 98419797 C A 15 98419885 G C 15 99434357 G A 15 99443139 G A 15 99443161 A G 15 99454245 A G 15 99454962 C T 15 99454994 G A 15 99458902 C T 15 99482903 C T 15 99485931 T A 15 99491540 G A 15 99500064 C T 15 100285424 T G 15 100333593 G A 15 100339833 G C 15 100339897 T C 15 100339938 C T 15 100340316 A C 15 100340375 A G 15 100340413 C T 15 100340484 A G 15 101110096 T C 15 102296008 G C 15 102296140 C T 15 102296231 C T 15 102300354 T C 15 102301640 T C 15 102301662 A C 15 102301669 G C 15 102303340 A G 15 102303423 A G 15 102303495 C A 15 102303519 G T 15 102304191 G C 15 102305129 T C 15 102305169 G T 15 102517868 G A 16 326817 C A 16 326826 C G 16 900140 A G 16 1872922 C G 16 1873332 G A 16 1873372 C T 16 2107489 C T 16 3020860 C G 16 3799857 T C 16 3828348 A G 16 4060980 T C 16 4985044 C T 16 5139217 C G 16 5143432 C G 16 5143976 C G 16 5145474 C T 16 5145847 G A 16 5145848 A G 16 5145883 A G 16 5146062 C G 16 5166093 A G 16 5338275 A G 16 5338313 C G 16 5527601 T A 16 6553772 G A 16 6554204 A C 16 6554253 C A 16 6554268 C T 16 7495752 C T 16 7496375 G T 16 8603974 A G 16 8603995 G C 16 8604458 A G 16 8604472 C T 16 8604479 A C 16 8604481 C T 16 8604503 A G 16 8604517 G A 16 8604540 A G 16 9928329 C T 16 9943995 A G 16 10273536 G T 16 10632828 A G 16 12019830 G A 16 12019883 A C 16 12019895 A G 16 12297011 C G 16 14781854 T A 16 14781862 T A 16 14782377 C A 16 14821494 C A 16 14864463 G A 16 14864910 G A 16 15047046 C G 16 15452301 C T 16 15460786 T C 16 15867652 T G 16 16789081 C T 16 16789406 C T 16 18450847 C T 16 18450961 G A 16 18543753 C T 16 19479406 C T 16 20575093 G A 16 20575307 G A 16 21844766 G A 16 21844944 A G 16 21844958 G C 16 23016538 G A 16 23632479 C T 16 23634026 A G 16 23637251 G C 16 23698547 G T 16 24888454 C T 16 25668649 C T 16 25668663 A C 16 26131607 A G 16 26132278 G T 16 26798205 G T 16 27947757 G A 16 28785263 T C 16 28871657 C A 16 29059935 G A 16 29060011 T A 16 29065054 C T 16 29314400 C T 16 29344359 C T 16 29344604 C T 16 29344690 C T 16 29398813 G A 16 31771741 T C 16 31771776 A G 16 31771780 A G 16 31771902 A G 16 31771903 A C 16 31771904 C T 16 31771907 A G 16 31771911 C A 16 31771914 C T 16 31771943 G T 16 31771944 C A 16 31771949 G A 16 31771953 A G 16 31772070 A G 16 32823016 C A 16 32823158 G A 16 32823526 C A 16 33070217 T C 16 48996185 C A 16 48996189 C A 16 48996630 C G 16 50809902 C G 16 50816660 C T 16 52671770 C T 16 53391457 G C 16 53564401 G C 16 55173502 T G 16 55692499 G A 16 56046208 A T 16 57045159 T C 16 57720488 G A 16 57720563 T C 16 57721127 G T 16 57721146 G A 16 58690676 G C 16 58691267 A G 16 61461212 A G 16 62213143 C T 16 63217610 G C 16 65540174 C T 16 68771034 C A 16 68771122 A C 16 68771547 G C 16 68820718 A G 16 68821271 G C 16 68847044 C T 16 68847712 G A 16 68849904 A G 16 68861864 G A 16 68863314 T C 16 70009172 G C 16 70224457 C G 16 70224541 T C 16 70235983 T C 16 71105150 A G 16 72007232 G A 16 72763955 G T 16 72991057 G T 16 73141028 G A 16 74422136 T C 16 74422332 A G 16 74427116 G A 16 76418228 C T 16 76907109 C A 16 77694411 T G 16 77694421 T A 16 78082862 C T 16 78082906 G A 16 78761364 A G 16 78761917 G C 16 79161532 A C 16 79704152 T C 16 81636255 A G 16 81636851 G A 16 82150582 A G 16 82527841 C T 16 83459041 C T 16 83691187 G A 16 85437616 T C 16 85437625 T C 16 85437629 G A 16 85437709 G A 16 85437722 T C 16 85437742 T C 16 85437752 A T 16 85437996 A T 16 85438220 G A 16 85438556 T A 16 85438649 A G 16 85438680 C T 16 85438700 C T 16 85441380 C G 16 85441405 G C 16 85441424 T C 16 85441812 A C 16 85442570 T C 16 85442574 A G 16 85443843 T C 16 85443876 G A 16 85443989 T G 16 85444082 G C 16 85444102 C A 16 85444107 C T 16 85444130 T C 16 85444204 C T 16 85444618 A G 16 85444655 A C 16 85444705 T C 16 85444849 A C 16 85445141 C T 16 85445267 C G 16 85445365 C T 16 86005933 C G 16 86005964 T G 16 86005984 G A 16 86006286 C T 16 87178517 A G 16 87179026 T C 16 87179050 G T 16 87179063 G A 16 87179102 G A 16 87179142 G A 16 87179180 C A 16 87648305 C T 16 87648315 T G 16 87648341 G A 16 87926558 G A 16 87926696 G C 16 88073139 C T 16 88073194 C T 16 88073218 T C 16 88073296 A G 16 88310744 C T 16 88310829 T C 16 88310830 G A 16 88310910 A G 16 88310955 A G 16 88310963 C G 16 88311269 A G 16 88311279 A T 16 88311285 A T 16 88311291 G C 16 88311355 T C 16 88312367 C T 16 88312750 C T 16 88312754 A G 16 88312962 C T 16 88312973 C T 16 88313227 C T 16 88313229 C T 16 88313255 A G 16 88313383 A G 16 88313402 T C 16 88313449 T C 16 88313454 T C 16 88313493 A G 16 88313505 A G 16 88313530 G T 16 88313585 A G 16 88313677 C T 16 88313845 C T 16 88794959 C A 16 88795086 T G 16 88795431 A T 16 88795433 C T 16 88795718 C T 16 89299506 A T 16 89299519 G C 16 89299899 A G 16 89756171 G A 16 89756185 A T 16 89806732 G A 16 89807543 G A 16 89808939 T C 16 89809548 C A 16 89809549 A G 16 89811151 A G 16 89811209 C T 16 89811663 T C 16 89811751 C G 16 89814818 T G 16 89815321 C T 16 89815824 G A 16 89816569 C A 16 89818340 G C 16 89818908 C T 16 89828043 T A 16 89839976 T C 16 89842479 T C 16 89849735 G A 16 89849740 C T 16 89851004 A G 16 89851033 C T 16 89998794 G A 16 90233312 C T 17 164435 C T 17 164955 C A 17 164967 T C 17 164969 C G 17 164980 C T 17 164997 T G 17 164999 C G 17 165010 T C 17 165025 T C 17 165071 C T 17 165078 C A 17 165085 C T 17 165090 G T 17 165147 T C 17 165201 C G 17 165240 C G 17 165247 C T 17 165256 C A 17 165295 T C 17 165357 C A 17 165375 A C 17 165386 T C 17 165409 C T 17 165419 A C 17 165501 T C 17 165515 T C 17 165562 C T 17 165565 G C 17 165576 T C 17 165585 G T 17 165615 G T 17 165643 C A 17 165694 A G 17 165695 C T 17 165712 T A 17 165732 T C 17 165736 C T 17 165742 G C 17 165966 T C 17 165976 C T 17 166081 T C 17 166186 C A 17 166346 A G 17 1020183 G A 17 1020394 G T 17 1022697 C T 17 1022705 G T 17 1022734 G A 17 1022796 G C 17 1022860 G C 17 1022923 C T 17 2257864 A G 17 2258637 A C 17 3315757 T C 17 3315904 G A 17 3771365 A C 17 3771379 G A 17 3771380 T C 17 3771381 G A 17 3771384 C A 17 5033768 C A 17 5034469 G A 17 5043998 C T 17 5603793 C T 17 6461283 A G 17 7569698 A C 17 7573229 C T 17 7576348 C T 17 8107979 G T 17 8109598 G A 17 8113186 A G 17 9756002 G T 17 9756057 T C 17 9756171 A T 17 9756198 T C 17 10095727 T G 17 11355538 C T 17 11356161 A C 17 11356178 G A 17 11924471 C T 17 12042934 T A 17 12968947 T C 17 12969339 G T 17 15486857 G A 17 15486909 A G 17 16012494 A T 17 16068096 C T 17 16528031 C T 17 17120668 G C 17 17625022 A G 17 17625107 T C 17 17625185 G T 17 18297214 C G 17 18299435 C T 17 18299631 C G 17 18393867 C T 17 19486126 C T 17 19486133 T C 17 19486148 T C 17 19486537 A G 17 19486585 C A 17 19486592 T C 17 20451455 A C 17 20453878 G T 17 21262861 G A 17 21408378 T C 17 21503001 G C 17 21825993 T G 17 21826038 T C 17 21826256 A G 17 21859750 A G 17 21901935 C G 17 21901936 C T 17 21901945 G C 17 22213908 C T 17 25746737 C A 17 25747067 C T 17 25747244 C T 17 25748176 C A 17 25748270 G T 17 25982703 C T 17 25983153 G A 17 26079849 T C 17 26087967 T A 17 26087978 A T 17 26088432 C G 17 27536646 T C 17 28043613 G A 17 28883741 C T 17 29541339 A T 17 29558082 T C 17 29592550 T C 17 29675878 T G 17 29684553 C T 17 30389991 G A 17 32084335 G T 17 32980299 C T 17 32980342 C A 17 33520071 C T 17 33520663 C T 17 34416275 T A 17 34416946 G A 17 34488320 G A 17 34587938 T C 17 34587942 C T 17 34754758 G C 17 34754836 A C 17 36097775 G A 17 36102035 G C 17 36103872 C G 17 36221809 T A 17 36578907 C T 17 36579428 C T 17 37230242 T C 17 37626963 G A 17 37646589 T C 17 37650569 G A 17 38561366 T C 17 38568249 C G 17 39383335 C G 17 39394674 A G 17 39394729 C A 17 39394755 C A 17 39394787 C A 17 39394790 T C 17 39394807 C A 17 39394885 C T 17 39394911 A G 17 39406673 T G 17 39604697 A G 17 40490539 T G 17 40490559 G T 17 40498273 T C 17 40498944 T C 17 41199913 T C 17 41205772 G A 17 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30064731 A G 22 31071644 A C 22 32813600 T C 22 32813975 C G 22 33171838 G T 22 34225927 C A 22 34226068 G A 22 34226412 C G 22 34226440 T C 22 34842414 G C 22 35843103 C T 22 35843109 C T 22 36678453 C G 22 36678476 C A 22 36679058 T C 22 38054038 A G 22 41514151 C T 22 41514155 G A 22 41536064 T C 22 41543721 G A 22 41544167 C T 22 41552926 T G 22 41554690 C T 22 41565285 A G 22 41565827 A G 22 41566823 A G 22 41570071 T C 22 42232577 C T 22 42232588 G A 22 42522312 T C 22 42522392 G A 22 42523003 A G 22 42523209 T C 22 42523211 T C 22 42526049 C G 22 42536064 T C 22 42536954 A G 22 42537023 T C 22 42537029 C T 22 42537115 C T 22 42537119 C T 22 42537127 A G 22 42537196 T C 22 42538399 C T 22 42539105 T C 22 42539720 C G 22 42540667 C T 22 42540668 A G 22 42547739 G A 22 42547755 C G 22 42548094 A G 22 42548880 G A 22 43735824 T C 22 44510034 T A 22 44510219 T C 22 44510230 T C 22 44510240 A G 22 44510329 C T 22 44510554 G A 22 44510624 A G 22 44510631 G T 22 44511408 G C 22 44511478 T C 22 44511626 T C 22 44511663 G C 22 45676445 C G 22 47002427 T C 22 47566744 G A 22 48301616 T C 22 48301642 C T 22 48301646 G A 22 48301660 C T 22 49258340 G C 22 49258341 G C 22 49258485 A G 22 49258525 A G 22 49258700 G C 22 49258701 G C 22 49551354 A G 22 49551680 G A 22 49551682 G A 22 49551684 A G 22 49551689 C A 22 49551690 C T 22 49551694 G A 22 49551724 G C 22 49551734 T C 22 49551749 G A 22 49551895 G A 22 49551927 G A 22 49551969 C T 22 49551990 T C 22 50017556 G A 22 51115526 T C 22 51115575 C T X 323851 G A X 323960 C T X 324085 G A X 324097 T C X 324135 G A X 324137 A C X 324137 A G X 324146 G A X 324224 C G X 324245 G A X 933046 T A X 933079 A T X 933848 C T X 1414936 C A X 1415582 A C X 1415726 G C X 1415754 A G X 1416082 A C X 1416494 A C X 1416825 A G X 1416859 C G X 1417722 A G X 1882476 C A X 1882644 G C X 1882671 T G X 1883661 T G X 2320736 C T X 2320768 C T X 2550218 A G X 2550271 T C X 3354064 T C X 3354073 C G X 3354304 T G X 3354320 C G X 3354323 T C X 3354489 C T X 3947844 G A X 3947940 G A X 3948055 A G X 3948056 C A X 3948072 C A X 3948325 A G X 5728321 G A X 5728524 T A X 6750277 G A X 6750665 T C X 7811259 G C X 7811504 G A X 7811645 C G X 7811747 T C X 7812017 C T X 7812081 C T X 7812197 T C X 8138080 G C X 8138160 T C X 8138165 C G X 8138170 C G X 8138171 T C X 8138182 A G X 8434256 A G X 8434367 C T X 8434432 A G X 8434433 G C X 8960281 C T X 9372403 A G X 9374934 C A X 9375163 A C X 9376287 T G X 9377057 G A X 9378063 T C X 9378595 C G X 9380687 C G X 9382151 T C X 9909935 T C X 9910404 A T X 9910483 C A X 11985475 C T X 11985898 A T X 12023301 C G X 12023305 A G X 12023314 A G X 12023535 G C X 13222032 G A X 13668792 C T X 13669007 G A X 14291097 G A X 14291174 G A X 14291313 T C X 14852765 G C X 15665327 C T X 16351394 T C X 16351704 C T X 16351825 A G X 17387641 A G X 17794293 A G X 17794390 G C X 18247605 T C X 21942691 C T X 22313514 G A X 22314058 G C X 22553123 A G X 22553314 G A X 24007345 T C X 26225293 C T X 26225571 C A X 26735568 A G X 26735679 G T X 27029285 C A X 28676918 A G X 28871324 A G X 28871343 A G X 28871801 C T X 29149454 G T X 29149490 A G X 30277764 C T X 30618867 T C X 31277151 C T X 32224435 T C X 32889854 G A X 33050164 T C X 34444321 T G X 35083559 C A X 35971670 A C X 35971684 A G X 36959988 C T X 39944288 C T X 40857040 C T X 41546554 C T X 43440829 T C X 43440856 T C X 44601065 T G X 45028722 T C X 45029140 A G X 45634577 C A X 47966001 A G X 48134195 T C X 48134267 C A X 48134283 A G X 48134352 G A X 48134363 T C X 48196483 C T X 48548091 C T X 49337861 G A X 49337915 G A X 50776337 A C X 51361920 C T X 54846603 C T X 54976385 T C X 55684550 G C X 55684552 A T X 55684553 T C X 57163476 C G X 62573853 A G X 67310673 G A X 67965273 C T X 70338399 A G X 70354080 C A X 70355942 G C X 70361608 T C X 70361619 T C X 70886761 G A X 70939147 G C X 72066630 C T X 74375460 C T X 74803555 T A X 75449353 G C X 75449473 A G X 75555810 C T X 76845060 C T X 76848940 C T X 76912391 T C X 76919991 T C X 77671395 A G X 78526387 C G X 79376181 C G X 79376359 G A X 79712450 C A X 81978259 A G X 82987871 T A X 82988286 T A X 83489042 C A X 84535451 A G X 85996514 A G X 86125877 C T X 86126034 A C X 86126184 C A X 86126214 C A X 88458887 G A X 88459088 A G X 88460086 C T X 88460163 C A X 88460234 C T X 88460693 C G X 88461023 A C X 88461098 G T X 88461193 G C X 88461257 T C X 88461306 C T X 88461381 G A X 88461454 G T X 88461489 G A X 89179384 G A X 89531825 G A X 90467751 C T X 90468268 A G X 90937645 C T X 90937839 C T X 91240753 G A X 91241043 C T X 91651454 G A X 91651560 T C X 91651589 T C X 91651601 C G X 94235658 G C X 97861548 G A X 97861806 C G X 100600966 C T X 100604681 C T X 100611432 G A X 100614597 C T X 100615025 G T X 100616989 C T X 100625293 C T X 100626864 C T X 100630500 G A X 101383199 T C X 102633394 A T X 105034364 C G X 106516125 G C X 107492960 G C X 108115548 C T X 111815818 T C X 114629506 T C X 114997566 A G X 115005861 T C X 115005934 C T X 115959641 C A X 116167250 G A X 117479815 C G X 119313694 G C X 122008986 A G X 122648454 T C X 122696563 C T X 122932585 A C X 123159474 T C X 123181551 G A X 123194867 T C X 123197557 T C X 123227604 T C X 124576157 G T X 125779449 T C X 125779655 C T X 126247979 C A X 127724972 C T X 128495450 C G X 130974130 T C X 130974165 A G X 130974206 G A X 130974276 A C X 130974277 A C X 130974284 G C X 130974290 C G X 130974310 T C X 130974312 G A X 132426862 G C X 135961796 C G X 137367771 T C X 138265862 A T X 138266294 T C X 139298295 C T X 139298601 C T X 139298612 T C X 139960824 T C X 140147409 A G X 140147500 C T X 140336615 T A X 140673061 C T X 140673198 T G X 140673372 C T X 140673423 G C X 140786796 G A X 140993642 C T X 140993905 C T X 140993912 C T X 140993913 C G X 140993945 T C X 140993947 T C X 140993989 T C X 140994031 G C X 140994037 C A X 142605437 A C X 142605455 C T X 142605483 A G X 142605491 G C X 142605583 C T X 142605628 G A X 142804302 T C X 142804326 C T X 143901920 T C X 143902298 G T X 144328894 C T X 144940393 G A X 146052064 T C X 146052294 G C X 146266206 T G X 146266521 G T X 146679744 A G X 146679975 T A X 146680129 C T X 149382872 C G X 149383074 A G X 150162380 C T X 152155921 C T X 152156110 C T X 152156144 A G X 152156176 G C X 152538286 A T X 152538627 G A X 152582526 G A X 153009797 G A X 153010224 C T X 153010267 G A X 154376753 C G X 155233098 T C


2. The use according to claim 1, wherein the evaluating homologous recombination deficiency is to calculate scoring HRD according to the following formula: HRD=LOH+TAI+LST, wherein LOH refers to a number of heterozygous loss regions of at least 15 Mb without spanning an entire chromosome; TAI refers to a number of allelic imbalances in front of telomere ends of chromosomes; and LST refers to a number of a chromosomal break region not greater than 3 Mb and a fragment of at least 10 Mb. 